全文获取类型
收费全文 | 543篇 |
免费 | 29篇 |
国内免费 | 4篇 |
专业分类
耳鼻咽喉 | 3篇 |
儿科学 | 27篇 |
妇产科学 | 7篇 |
基础医学 | 52篇 |
口腔科学 | 22篇 |
临床医学 | 77篇 |
内科学 | 144篇 |
皮肤病学 | 15篇 |
神经病学 | 38篇 |
特种医学 | 14篇 |
外科学 | 68篇 |
综合类 | 6篇 |
预防医学 | 32篇 |
眼科学 | 9篇 |
药学 | 36篇 |
肿瘤学 | 26篇 |
出版年
2024年 | 1篇 |
2023年 | 5篇 |
2022年 | 14篇 |
2021年 | 31篇 |
2020年 | 29篇 |
2019年 | 25篇 |
2018年 | 20篇 |
2017年 | 20篇 |
2016年 | 27篇 |
2015年 | 21篇 |
2014年 | 33篇 |
2013年 | 39篇 |
2012年 | 55篇 |
2011年 | 63篇 |
2010年 | 32篇 |
2009年 | 20篇 |
2008年 | 20篇 |
2007年 | 26篇 |
2006年 | 23篇 |
2005年 | 15篇 |
2004年 | 19篇 |
2003年 | 9篇 |
2002年 | 12篇 |
2001年 | 6篇 |
2000年 | 1篇 |
1999年 | 3篇 |
1998年 | 1篇 |
1997年 | 1篇 |
1996年 | 2篇 |
1995年 | 2篇 |
1985年 | 1篇 |
排序方式: 共有576条查询结果,搜索用时 140 毫秒
71.
Hussein K Hayek T Yassin K Fischer D Vlodavsky E Kra-Oz Z Hamoud S 《The American journal of the medical sciences》2006,331(1):40-43
A 29-year-old man was admitted with high-grade fever, crampy abdominal pain, and watery diarrhea that had persisted for 2 weeks before his admission. Symptomatic treatment (acetaminophen only) was of no benefit. On physical examination, there was diffuse abdominal tenderness. Laboratory tests showed a leukomoid reaction with atypical lymphocytosis, and serology tests revealed acute cytomegalovirus infection. Abdominal computed tomography and colonoscopy revealed an inflammatory process involving the large intestine. On histologic examinations of intestinal biopsy samples, there was an active inflammation with no inclusion bodies.The patient was treated with ganciclovir with only mild improvement. Adding 5-aminosalicylic acid caused little further improvement. Repeated colonoscopy performed 2 months later showed severe chronic ulcerative colitis. Only the addition of systemic steroids caused complete resolution of the symptoms.On review of the literature (Medline search for cytomegalovirus colitis in immunocompetent patients), 18 cases were found. On follow-up, 10 of these patients were found to have inflammatory bowel disease. 相似文献
72.
Five species of mycobacteria were stained by Ziehl-Neelsen, Kinyoun and Auramine-Rhodamine after either routine autoclaving, or exposure to rifabutin and ciprofloxacin. Organisms from each treatment group were stained and compared to viable controls. ATCC strains and fresh clinical isolates of all five species were evaluated. All species in both treatment protocols presented similar staining characteristics. Viability of mycobacteria, therefore, must be established by culture. 相似文献
73.
Georgia Papacleovoulou Shadi Abu-Hayyeh Evanthia Nikolopoulou Oscar Briz Bryn M. Owen Vanya Nikolova Caroline Ovadia Xiao Huang Marja Vaarasmaki Marc Baumann Eugene Jansen Christiane Albrecht Marjo-Riitta Jarvelin Jose J.G. Marin A.S. Knisely Catherine Williamson 《The Journal of clinical investigation》2013,123(7):3172-3181
The intrauterine environment is a major contributor to increased rates of metabolic disease in adults. Intrahepatic cholestasis of pregnancy (ICP) is a liver disease of pregnancy that affects 0.5%–2% of pregnant women and is characterized by increased bile acid levels in the maternal serum. The influence of ICP on the metabolic health of offspring is unknown. We analyzed the Northern Finland birth cohort 1985–1986 database and found that 16-year-old children of mothers with ICP had altered lipid profiles. Males had increased BMI, and females exhibited increased waist and hip girth compared with the offspring of uncomplicated pregnancies. We further investigated the effect of maternal cholestasis on the metabolism of adult offspring in the mouse. Females from cholestatic mothers developed a severe obese, diabetic phenotype with hepatosteatosis following a Western diet, whereas matched mice not exposed to cholestasis in utero did not. Female littermates were susceptible to metabolic disease before dietary challenge. Human and mouse studies showed an accumulation of lipids in the fetoplacental unit and increased transplacental cholesterol transport in cholestatic pregnancy. We believe this is the first report showing that cholestatic pregnancy in the absence of altered maternal BMI or diabetes can program metabolic disease in the offspring. 相似文献
74.
Biodegradable injectable polyurethanes: synthesis and evaluation for orthopaedic applications 总被引:2,自引:1,他引:1
Adhikari R Gunatillake PA Griffiths I Tatai L Wickramaratna M Houshyar S Moore T Mayadunne RT Field J McGee M Carbone T 《Biomaterials》2008,29(28):3762-3770
Biodegradable polyurethanes offer advantages in the design of injectable or preformed scaffolds for tissue engineering and other medical implant applications. We have developed two-part injectable prepolymer systems (prepolymer A and B) consisting of lactic acid and glycolic acid based polyester star polyols, pentaerythritol (PE) and ethyl lysine diisocyanate (ELDI). This study reports on the formulation and properties of a series of cross linked polyurethanes specifically developed for orthopaedic applications. Prepolymer A was based on PE and ELDI. Polyester polyols (prepolymer B) were based on PE and dl-lactic acid (PEDLLA) or PE and glycolic acid (PEGA) with molecular weights 456 and 453, respectively. Several cross linked porous and non-porous polyurethanes were prepared by mixing and curing prepolymers A and B and their mechanical and thermal properties, in vitro (PBS/37 degrees C/pH 7.4) and in vivo (sheep bi-lateral) degradation evaluated. The effect of incorporating beta-tricalcium phosphate (beta-TCP, 5 microns, 10 wt.%) was also investigated. The cured polymers exhibited high compressive strength (100-190 MPa) and modulus (1600-2300 MPa). beta-TCP improved mechanical properties in PEDLLA based polyurethanes and retarded the onset of in vitro and in vivo degradation. Sheep study results demonstrated that the polymers in both injectable and precured forms did not cause any surgical difficulties or any adverse tissue response. Evidence of new bone growth and the gradual degradation of the polymers were observed with increased implant time up to 6 months. 相似文献
75.
76.
77.
Ashjaei S Miller WP Cabrera ML Hassan SM 《International journal of environmental research and public health》2011,8(5):1534-1546
In regions of concentrated poultry production, poultry litter (PL) that contains significant quantities of trace elements is commonly surface-applied to pastures at high levels over multiple years. This study examined the effect of long-term applications of PL on soil concentrations of arsenic (As), copper (Cu), Zinc (Zn), and the uptake of these elements by bermuda grass grown on Cecil (well-drained) and Sedgefield (somewhat poorly-drained) soils. The results showed that concentrations of As, Cu, and Zn in soils that had received surface-applied PL over a 14-year period were significantly greater than untreated soil at 0-2.5 and 2.5-7.5 cm depths. However, the levels were well below the USEPA loading limits established for municipal biosolids. Arsenic fractionation showed that concentrations of all As fractions were significantly greater in PL-amended soils compared to untreated soils at 0-2.5 and 2.5-7.5 cm depths. The residual fraction was the predominant form of As in all soils. The water-soluble and NaHCO(3)-associated As were only 2% of the total As. Significant differences were found in concentrations of these trace elements and phosphorus (P) in forage from PL-amended soils compared to that in untreated plots. The concentrations of Cu, Zn, As, and P were significantly greater in forage from Sedgefield amended soil compared to Cecil soil, but were in all cases below levels of environmental concern. 相似文献
78.
79.
80.
Frontera Jennifer A. Bhatt Prachi Lalchan Rebecca Yaghi Shadi Ahuja Tania Papadopoulos John Joset Danielle 《Journal of thrombosis and thrombolysis》2020,49(1):121-131
Journal of Thrombosis and Thrombolysis - Andexanet-alpha is a specific reversal agent for direct factor Xa inhibitors (dFXaI). We aimed to project utilization rates and cost of andexanet for... 相似文献