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991.
992.
Jianping Jia Cuibai Wei Shuoqi Chen Fangyu Li Yi Tang Wei Qin Lina Zhao Hongmei Jin Hui Xu Fen Wang Aihong Zhou Xiumei Zuo Liyong Wu Ying Han Yue Han Liyuan Huang Qi Wang Dan Li Serge Gauthier 《Alzheimer's & dementia》2018,14(4):483-491
Introduction
The socioeconomic costs of Alzheimer's disease (AD) in China and its impact on global economic burden remain uncertain.Methods
We collected data from 3098 patients with AD in 81 representative centers across China and estimated AD costs for individual patient and total patients in China in 2015. Based on this data, we re-estimated the worldwide costs of AD.Results
The annual socioeconomic cost per patient was US $19,144.36, and total costs were US $167.74 billion in 2015. The annual total costs are predicted to reach US $507.49 billion in 2030 and US $1.89 trillion in 2050. Based on our results, the global estimates of costs for dementia were US $957.56 billion in 2015, and will be US $2.54 trillion in 2030, and US $9.12 trillion in 2050, much more than the predictions by the World Alzheimer Report 2015.Discussion
China bears a heavy burden of AD costs, which greatly change the estimates of AD cost worldwide. 相似文献993.
994.
995.
Vincent Algalarrondo Romain Perault Marie-Cécile Bories Kumar Narayanan Rodrigue Garcia Nicolas Combes Marie-Cécile Perier Pascal Defaye Nicolas Sadoul Daniel Gras Didier Klug Pierre Bordachar Laurent Fauchier Jean-Claude Deharo Christophe Leclercq Serge Boveda Eloi Marijon Dominique Babuty 《Archives of Cardiovascular Diseases》2018,111(12):758-765
996.
997.
Serge Mordon 《Journal of cosmetic and laser therapy》2018,20(4):223-228
Hidradenitis suppurativa is a chronic, recurring, and disabling inflammatory condition of the skin. There is no cure for hidradenitis suppurativa and treatment must be adapted to each individual patient. Several studies have been published since 2004 on the use of photodynamic therapy to treat hidradenitis suppurativa. The use of superficial or interstitial illumination with 5-amino-levulinic acid (5-ALA) or methylene blue (MB) have been proposed. Injecting 5-ALA or MB followed by illumination with a fiber optic sensor placed inside the lesion appears to be a better method of treating these thick lesions. 相似文献
998.
Wagner Judith N. Schwarz Gabriele Puttinger Gertraud Hengsberger Anna Maria Guggenberger Stefan Weis Serge Trenkler Johannes Aichholzer Martin Oertzen Tim J. von 《Journal of neurology》2018,265(7):1708-1710
Journal of Neurology - 相似文献
999.
Serge A. Mitelman Monte S. Buchsbaum Derek S. Young M. Mehmet Haznedar Eric Hollander Lina Shihabuddin Erin A. Hazlett Marie-Cecile Bralet 《Brain imaging and behavior》2018,12(5):1290-1305
Both autism spectrum disorder (ASD) and schizophrenia are often characterized as disorders of white matter integrity. Multimodal investigations have reported elevated metabolic rates, cerebral perfusion and basal activity in various white matter regions in schizophrenia, but none of these functions has previously been studied in ASD. We used 18fluorodeoxyglucose positron emission tomography to compare white matter metabolic rates in subjects with ASD (n?=?25) to those with schizophrenia (n?=?41) and healthy controls (n?=?55) across a wide range of stereotaxically placed regions-of-interest. Both subjects with ASD and schizophrenia showed increased metabolic rates across the white matter regions assessed, including internal capsule, corpus callosum, and white matter in the frontal and temporal lobes. These increases were more pronounced, more widespread and more asymmetrical in subjects with ASD than in those with schizophrenia. The highest metabolic increases in both disorders were seen in the prefrontal white matter and anterior limb of the internal capsule. Compared to normal controls, differences in gray matter metabolism were less prominent and differences in adjacent white matter metabolism were more prominent in subjects with ASD than in those with schizophrenia. Autism spectrum disorder and schizophrenia are associated with heightened metabolic activity throughout the white matter. Unlike in the gray matter, the vector of white matter metabolic abnormalities appears to be similar in ASD and schizophrenia, may reflect inefficient functional connectivity with compensatory hypermetabolism, and may be a common feature of neurodevelopmental disorders. 相似文献
1000.
Matthan W. A. Caan Pierre‐Louis Bazin Jos P. Marques Gilles de Hollander Serge O. Dumoulin Wietske van der Zwaag 《Human brain mapping》2019,40(6):1786-1798
Quantitative magnetic resonance imaging generates images of meaningful physical or chemical variables measured in physical units that allow quantitative comparisons between tissue regions and among subjects scanned at the same or different sites. Here, we show that we can acquire quantitative T1, T2*, and quantitative susceptibility mapping (QSM) information in a single acquisition, using a multi‐echo (ME) extension of the second gradient‐echo image of the MP2RAGE sequence. This combination is called MP2RAGE ME, or MP2RAGEME. The simultaneous acquisition results in large time savings, perfectly coregistered data, and minimal image quality differences compared to separately acquired data. Following a correction for residual transmit B1+‐sensitivity, quantitative T1, T2*, and QSM values were in excellent agreement with those obtained from separately acquired, also B1+‐corrected, MP2RAGE data and ME gradient echo data. The quantitative values from reference regions of interests were also in very good correspondence with literature values. From the MP2RAGEME data, we further derived a multiparametric cortical parcellation, as well as a combined arterial and venous map. In sum, our MP2RAGEME sequence has the benefit in large time savings, perfectly coregistered data and minor image quality differences. 相似文献