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排序方式: 共有7198条查询结果,搜索用时 15 毫秒
81.
Terue Okamura Toshiko Kobashi Joji Kawabe Hironobu Ochi Yasuto Onoyama Seiji Yamagami 《Journal of bone and mineral metabolism》1994,12(Z1):S111-S116
Renal osteodystrophy (ROD) accompanied by long-term hemodialysis patients with chronic renal failure includes several forms
of disorders of mineral and skeletal metabolism such as osteitis fibrosa attributed to secondary hyperparathyroidism, osteomalasia
and adynamic bone disease. Bone scan is performed to detect of the mainly pathophysiology of ROD. We investigated bone scan
of 25 hemodialysis patients with secondary hyperparathyroidism diagnosed clinically before and after parathyroidectomy (PTX).
Before PTX an diffusely high accumulation of bone seeking agent in the whole skeleton especially skull in all patients (100%),
vertebra in 24 out of 25 (96%), patella in 24/25 (96%), limbs in 23/25 (92%), sternum in 19/25 (76%), sacrum in 18/25 (72%)
and costochondral junctions in 14/25 (56%) was noted in these patients. The radionuclide activity of the calvaria, maxilla
and mandible in the skull was prominently high. Fourteen patients had an equally high activity in the calvaria, maxilla and
mandible, 6 patients had higher activity in the maxilla and mandible than that of calvaria and 5 patients had higher in the
calvaria than that of maxilla and mandible. After PTX the changes in the skull were obvious in 19 patients who showed a more
markedly decreased in activity of the maxilla and mandible than that of the calvaria. In 3 patients showed a more markedly
decreased in activity of the calvaria than that of the maxilla and mandible. Another 3 demonstrated equally decreased in activity
in the calvaria, maxilla and mandible. It became clear that the highest activity of the skull was shown in all patients and
the therapeutic changes of the skull are the most pronounced in maxilla and mandible in this study. 相似文献
82.
83.
Tatsuro Kono Hiroko Kurome Yuzo Shibuya Seiji Hayasaka 《Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie》1995,233(11):667-671
Background: Nevus of Ota is common in Japanese women, but most patients are not examined ophthalmologically. Methods: We performed ophthalmologic examinations on 16 Japanese women who had had bluish pigmentation in the periorbital region, sclera, and conjunctiva since birth. Results: Fifteen patients had unilateral involvement, and one had bilateral lesions. The visual acuities were good, and the intraocular pressures were within normal range. All patients had a negative family history. Three patients had light pigmentation in the optic disc in the affected eye. Conclusion: We believe that optic disc pigmentation associated with nevus of Ota, as found in these three patients, may be common but have been rarely described. 相似文献
84.
85.
Ichinose Y Okino T Yamasaki S Moriguchi Y Sugie T Li L Kanaoka S Kan N Watanabe Y Imamura M 《Surgery today》1999,29(4):338-343
To evaluate the effect of interferon-γ-genetransduced cells, DS mice were inoculated into their footpads with syngeneic mammary
adenocarcinoma SC42 admixed with interferon-γ producing mammary adenocarcinoma SC115Kγ, which had been established by an interferon-γ-gene
transduction in another syngeneic mammary adenocarcinoma SC115 using retroviral vectors. These mice rejected both tumor cells
and developed resistance to subsequent challenges with either SC115 or SC42 cells inoculated into their opposite posterior
footpads. These results thus indicate that systemic immunological memory to each of the independent tumor cell lines developed
in these mice. Although the SC42 cells admixed with irradiated SC115Kγ cells were rejected by these mice, the SC42 cells admixed
with irradiated SC115neoR, in which the neo-gene had been transduced, were observed to proliferate. Tumor rejection was reversed
by an in vivo administration of anti-interferon-γ antibody, thus suggesting that locally produced interferon-γ plays an important
role in tumor elimination and immunological memory induction. In conclusion, interferon-γ-gene-transduced tumor cells are
therefore considered to have a therapeutic potential for other types of malignant tumor cell lines. 相似文献
86.
Primary anorectal malignant melanoma: Report of a case 总被引:3,自引:0,他引:3
Ojima Y Nakatsuka H Haneji H Kurihara T Sadamoto S Ohmoto T Katayama N Taniyama K 《Surgery today》1999,29(2):170-173
(Received for publication on Aug. 18, 1997; accepted on May 15, 1998) 相似文献
87.
K. Fujiki Yoshihiro Hotta Mutsuko Hayakawa Akio Saito Yukihiko Mashima Mikiro Mori Masaru Yoshii Akira Murakami Masayuki Matsumoto Seiji Hayasaka Nobuko Tagami Yasushi Isashiki Norio Ohba Atsushi Kanai 《Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie》1999,237(9):735-740
· Background: Choroideremia (CHM) is an X-linked progressive dystrophy of the choroid, retinal pigment epithelium, and retina.
Recently, the REP-1 gene was isolated and the causative mutations in the gene were detected in patients with CHM. In a previous study, we described
a Japanese family with CHM who had a mutation in the REP-1 gene. In the present study, we performed extensive analysis of the REP-1 gene in patients with CHM from several institutions in Japan. · Methods: Twenty-six patients with CHM and 5 unaffected females
from 22 independently ascertained families were examined. Exons 1–15 of the REP-1 gene were screened by single-strand conformation polymorphism. The DNA fragments suspected of any variations were directly
sequenced. · Results: Fifteen different mutations, including one previously reported mutation, were detected in 18 families.
In addition, carrier status was proven in four unaffected females found to be heterozygous for the mutant allele. · Conclusions:
Fifteen different mutations of the REP-1 gene were detected in 18 Japanese families. There were no hot spots for the mutations and no missense mutations. The results
show that REP-1 gene defects cause CHM in Japanese patients, and the mutations in these Japanese patients differed from the mutations reported
for CHM patients in Europe, Canada, and America except for R267X and 1313delTC. These findings suggest that the mutations
occurred independently in the Japanese patients.
Received: 13 August 1998 Revised version received: 16 November 1998 Accepted: 9 December 1998 相似文献
88.
Akihiko Kimura Tomoji Uda Shoichi Nakashima Haruhiko Ikeda Seiji Yasuda Motoki Osawa Tsutomu Tsuji 《International journal of legal medicine》1993,106(1):1-4
Summary The erythrocyte band 3 (EPB3) variant, band 3 Memphis (EPB3*Memphis), was detected by immunoblotting with a monoclonal antibody to the 41 kDa cytoplasmic N-terminal domain of band 3 without protease treatment of erythrocytes. EPB3*Memphis was also detected by immunoblotting from 3-month-old bloodstains subjected to -chymotrypsin treatment. A population genetic study using this method indicated that the EPB3 variant would be useful for forensic work in Japan, since the frequency of this variant in Japanese (Wakayama prefecture) is relatively high (0.159). 相似文献
89.
90.