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101.
This study investigated the emotional consequences for parents following the death of their child. Bereaved parents and age and gender-matched peers completed measures of physical health, depression, post-traumatic stress, and personal coping resources. To investigate the regulation of emotional reactions, the authors used a new instrument consisting of 4 scales: adaptive emotion regulation, confiding in others as a means to feeling better, avoiding and hiding emotions, and controlling the emotional impact by distorting awareness and communication. The bereaved parents were severely affected by the loss; they reported high distress levels. However, parents both in the bereavement group as well as in a comparison group who had experienced human loss showed better ability to control emotions adaptively compared with those who did not report such losses. The result is discussed in terms of lifespan development and personal growth. 相似文献
102.
Guillaume Vaquer Richard Magous Gérard Cros Anne Wojtusciszyn Eric Renard Hughes Chevassus Pierre Petit Anne‐Dominique Lajoix Catherine Oiry 《Fundamental & clinical pharmacology》2013,27(6):669-671
Hyperglycemia is a well‐known inducing factor of oxidative stress through activation of NADPH oxidase. In addition to its plasma glucose lowering effect, insulin may also have antioxidant activity and was shown to downregulate NADPH oxidase expression in vitro. In this study, we show that a short‐term (3‐day) intravenous insulin infusion in patients with type 2 diabetes induces normalization of both glycemia and mRNA expression of circulating monocyte p47phox subunit. 相似文献
103.
Jan Kottner Janet Cuddigan Keryln Carville Katrin Balzer Dan Berlowitz Susan Law Mary Litchford Pamela Mitchell Zena Moore Joyce Pittman Dominique Sigaudo-Roussel Chang Yee Yee Emily Haesler 《Journal of tissue viability》2019,28(2):51-58
Aim
The European Pressure Ulcer Advisory Panel, the Pan Pacific Pressure Injury Alliance, and the National Pressure Ulcer Advisory Panel are updating the ‘Prevention and Treatment of Pressure Ulcers: Clinical Practice Guideline’ (CPG) in 2019. The aim of this contribution is to summarize and to discuss the guideline development protocol for the 2019 update.Methods
A guideline governance group determines and monitors all steps of the CPG development. An international survey of consumers will be undertaken to establish consumer needs and interests. Systematic evidence searches in relevant electronic databases cover the period from July 2013 through August 2018. Risk of bias of included studies will be assessed by two reviewers using established checklists and an overall strength of evidence assigned to the cumulative body of evidence. Small working groups review the evidence available for each topic, review and/or draft the guideline chapters and recommendations and/or good practice statements. Finally, strength of recommendation grades are assigned. The recommendations are rated based on their importance and their potential to improve individual patient outcomes using an international formal consensus process.Discussion
Major methodological advantages of the current revision are a clear distinction between evidence-based recommendations and good practice statements and strong consumer involvement.Conclusion
The 2019 guideline update builds on the previous 2014 version to ensure consistency and comparability. Methodology changes will improve the guideline quality to increase clarity and to enhance implementation and compliance. The full guideline development protocol can be accessed from the guideline website (http://www.internationalguideline.com/). 相似文献104.
105.
Karin Nyg?rd ?yvind Werner-Johansen Svein R?nsen Dominique A Caugant ?ystein Simonsen Anita Kanestr?m Eirik Ask Jetmund Ringstad Rune ?deg?rd Tore Jensen Truls Krogh E Arne H?iby Eivind Ragnhildstveit Ingeborg S Aaberge Preben Aavitsland 《Clinical infectious diseases》2008,46(1):61-69
BACKGROUND: On 21 May 2005, the Norwegian health authorities were alerted by officials from a local hospital that several recent patients had received the diagnosis of legionnaires disease; all patients resided in 2 neighboring municipalities. We investigated the outbreak to identify the source and to implement control measures. METHODS: We interviewed all surviving case patients and investigated and harvested samples from 23 businesses with cooling towers and other potential infection sources. The locations of the businesses and the patients' residences and movements were mapped. We calculated attack rates and risk ratios among people living within various radii of each potential source. Isolates of Legionella pneumophila were compared using molecular methods. RESULTS: Among 56 case patients, 10 died. The case patients became ill 12-25 May, resided up to 20 km apart, and had not visited places in common. Those living up to 1 km from a particular air scrubber had the highest risk ratio, and only for this source did the risk ratio decrease as the radius widened. Genetically identical L. pneumophila serogroup 1 isolates were recovered from patients and the air scrubber. The air scrubber is an industrial pollution-control device that cleans air for dust particles by spraying with water. The circulating water had a high organic content, pH of 8-9, and temperature of 40 degrees C. The air was expelled at 20 m/s and contained a high amount of aerosolized water. CONCLUSIONS: The high velocity, large drift, and high humidity in the air scrubber may have contributed to the wide spread of Legionella species, probably for >10 km. The risk of Legionella spread from air scrubbers should be assessed. 相似文献
106.
Dietary iron regulates hepatic hepcidin 1 and 2 mRNAs in mice 总被引:3,自引:0,他引:3
Mazur A Feillet-Coudray C Romier B Bayle D Gueux E Ruivard M Coudray C Rayssiguier Y 《Metabolism: clinical and experimental》2003,52(10):1229-1231
107.
108.
Benoit D Decruyenaere J Depuydt P Colpaert K 《Lancet》2004,363(9403):170; author reply 170-170; author reply 171
109.
110.
Increased risk of myocardial infarction with duration of protease inhibitor therapy in HIV-infected men 总被引:22,自引:0,他引:22
Mary-Krause M Cotte L Simon A Partisani M Costagliola D;Clinical Epidemiology Group from the French Hospital Database 《AIDS (London, England)》2003,17(17):2479-2486
BACKGROUND: In the current context of dyslipidaema, hyperglycaema and lipodystrophia observed among HIV-seropositive subjects, it is important to study the risk of myocardial infarction (MI) in this population. The French Hospital Database on HIV, which includes a large number of seropositive subjects followed for substantial periods, offers the opportunity to analyse the impact of protease inhibitors (PI) on the risk of MI among men. METHODS: Cox model was used to study the risk factors of MI occurrence. Standardized morbidity ratios (SMR) in men exposed to PI were calculated with data from the French general male population (FGMP) of the same age as reference. RESULTS: Between 1996 and 1999, MI was diagnosed in 60 men among 88 029 person-years (PY), including 49 cases among men exposed to PI. In the Cox model, exposure to PI was associated with a higher risk of MI [relative hazard (RH), 2.56; 95% confidence interval (CI), 1.03-6.34]. The expected incidence in the FGMP was 10.8/10,000 PY. The SMR relative to the FGMP was 0.8 (95% CI, 0.5-1.3) for men exposed to PI for < 18 months (G1), 1.5 (95% CI, 0.8-2.5) for men exposed for 18-29 months (G2) and 2.9 (95% CI, 1.5-5.0) for men exposed for >or= 30 months (G3). With G1 as reference, the SMR was 1.9 (95% CI, 1.0-3.1) for G2 and 3.6 (95% CI, 1.8-6.2) for G3. CONCLUSION: Our results point to a duration-related effect relationship between PI and MI, with a higher MI incidence rate among men exposed to PI for 18 months or more. 相似文献