全文获取类型
收费全文 | 2798篇 |
免费 | 181篇 |
国内免费 | 84篇 |
专业分类
耳鼻咽喉 | 16篇 |
儿科学 | 126篇 |
妇产科学 | 46篇 |
基础医学 | 300篇 |
口腔科学 | 104篇 |
临床医学 | 341篇 |
内科学 | 531篇 |
皮肤病学 | 195篇 |
神经病学 | 172篇 |
特种医学 | 359篇 |
外科学 | 351篇 |
综合类 | 40篇 |
预防医学 | 151篇 |
眼科学 | 49篇 |
药学 | 137篇 |
中国医学 | 2篇 |
肿瘤学 | 143篇 |
出版年
2022年 | 14篇 |
2021年 | 23篇 |
2020年 | 12篇 |
2019年 | 28篇 |
2018年 | 43篇 |
2017年 | 43篇 |
2016年 | 55篇 |
2015年 | 68篇 |
2014年 | 49篇 |
2013年 | 84篇 |
2012年 | 95篇 |
2011年 | 83篇 |
2010年 | 95篇 |
2009年 | 87篇 |
2008年 | 97篇 |
2007年 | 125篇 |
2006年 | 93篇 |
2005年 | 105篇 |
2004年 | 94篇 |
2003年 | 78篇 |
2002年 | 93篇 |
2001年 | 69篇 |
2000年 | 66篇 |
1999年 | 81篇 |
1998年 | 115篇 |
1997年 | 101篇 |
1996年 | 130篇 |
1995年 | 104篇 |
1994年 | 105篇 |
1993年 | 89篇 |
1992年 | 43篇 |
1991年 | 45篇 |
1990年 | 52篇 |
1989年 | 54篇 |
1988年 | 52篇 |
1987年 | 40篇 |
1986年 | 52篇 |
1985年 | 48篇 |
1984年 | 30篇 |
1983年 | 25篇 |
1982年 | 26篇 |
1981年 | 30篇 |
1980年 | 20篇 |
1978年 | 22篇 |
1977年 | 34篇 |
1976年 | 28篇 |
1975年 | 19篇 |
1974年 | 14篇 |
1971年 | 19篇 |
1970年 | 14篇 |
排序方式: 共有3063条查询结果,搜索用时 62 毫秒
81.
FJ O'Callaghan AC Clarke H Joffe B Keeton R Martin A Salmon RD Thomas JP Osborne 《Archives of disease in childhood》1998,78(2):159-162
This report highlights the association between tuberous sclerosis and Wolff-Parkinson-White syndrome. Ten patients with concurrent diagnoses of Wolff-Parkinson-White syndrome and tuberous sclerosis were identified. Wolff-Parkinson-White syndrome presented early in life, nine cases being diagnosed in the first year. Eight of the 10 cases were male. In eight cases, the syndrome was associated with supraventricular tachycardias, and in nine with cardiac rhabdomyomata. One child died from cardiac failure secondary to obstruction of the left ventricular outflow tract by a rhabdomyoma. Five of nine survivors showed resolution of Wolff-Parkinson-White syndrome on follow up. The accessory pathway was localised in nine patients from surface electrocardiograms: six children had left sided pathways and three had right sided pathways. 相似文献
82.
Iron-overload diseases frequently develop hepatocellular carcinoma. The
genotoxic mechanism whereby iron is involved in hepatocarcinogenesis might
involve an oxidative process via the intermediate production of reactive
oxygen species. This was presently investigated by examining kinetics of
formation and repair of DNA base lesions in primary rat hepatocyte cultures
supplemented with the iron chelate, ferric nitrilotriacetate Fe-NTA (10 and
100 microM). Seven DNA base oxidation products have been identified in DNA
extracts by gas chromatography- mass spectrometry, which showed a
predominance of oxidized-purines (8- oxo-guanine, xanthine, fapy-adenine,
2-oxo-adenine) above oxidized pyrimidines (5-OHMe-uracil, 5-OH-uracil,
5-OH-cytosine) in control cultures. All these DNA oxidation products
revealed a significant dose- dependent increase at 4 to 48 h after Fe-NTA
supplementation, among which fapy-adenine showed the highest increase and
5-OH-cytosine was the least prominent. Involvement of iron in this
oxidative process was established by a correlation between extent in DNA
oxidation and intracellular level of toxic low molecular weight iron. DNA
excision- repair activity was estimated by release of DNA oxidation
products in culture medium. All the seven DNA oxidation products were
detected in the medium of control cultures and showed basal repair
activity. This DNA repair activity was increased in a time- and
dose-dependent fashion with Fe-NTA. Oxidized-pyrimidines, among which was
5-OHMe-Uracil, were preferentially repaired, which explains the low levels
detected in oxidized DNA. Since oxidized bases substantially differed from
one another in terms of excision rates from cellular DNA, specific
excision- repair enzymes might be involved. Our findings, however,
demonstrate that even though DNA repair pathways were activated in
iron-loaded hepatocyte cultures, these processes were not stimulated enough
to prevent an accumulation of highly mutagenic DNA oxidative products in
genomic DNA. The resulting genotoxic effect of Fe-NTA might be relevant in
understanding the hepatocarcinogenic evolution of iron-overload diseases.
相似文献
83.
Jean-Blaise Wasserfallen Alexandre Berger Philippe Eckert Jean-Christophe Stauffer Jürg Schlaepfer Dominique Gillis Jacques Cornuz Marie-Denise Schaller Lukas Kappenberger Bertrand Yersin 《International journal for quality in health care》2004,16(5):383-389
OBJECTIVE: To assess the impact of introducing clinical practice guidelines on acute coronary syndrome without persistent ST segment elevation (ACS) on patient initial assessment. DESIGN: Prospective before-after evaluation over a 3-month period. SETTING: The emergency ward of a tertiary teaching hospital. PATIENTS: All consecutive patients with ACS evaluated in the emergency ward over the two 3-month periods. INTERVENTION: Implementation of the practice guidelines, and the addition of a cardiology consultant to the emergency team. MAIN OUTCOME MEASURES: Diagnosis, electrocardiogram interpretation, and risk stratification after the initial evaluation. RESULTS: The clinical characteristics of the 328 and 364 patients evaluated in the emergency ward for suspicion of ACS before and after guideline implementation were similar. Significantly more patients were classified as suffering from atypical chest pain (39.6% versus 47.0%; P = 0.006) after guideline implementation. Guidelines availability was associated with significantly more formal diagnoses (79.9% versus 92.9%; P < 0.0001) and risk stratification (53.7% versus 65.4%, P < 0.0001) at the end of initial assessment. CONCLUSION: Guidelines implementation, along with availability of a cardiology consultant in the emergency room had a positive impact on initial assessment of patients evaluated for suspicion of ACS. It led to increased confidence in diagnosis and stratification by risk, which are the first steps in initiating effective treatment for this common condition. 相似文献
84.
85.
ANA JP MORAES POLLYANA MF SOARES AURA L ZAPATA ANA PN LOTITO ADRIANA ME SALLUM CLOVIS AA SILVA 《Pediatrics international》2006,48(1):48-53
Background: The purpose of the present paper was to describe the clinical manifestations and treatment of patients with panniculitis. Methods: From January 1983 to December 2002, 4294 patients were treated for pediatric rheumatological diseases at Pediatric Rheumatology Unit, University of São Paulo, Brazil. Of these, 35 children and adolescents (0.8%) presented with panniculitis: erythema nodosum (EN) or Weber–Christian disease (WCD). Clinical characteristics, laboratory exams, biopsy of the lesion, treatment and clinical course were studied. Results: Of the 35 patients, 29 presented with EN and six with WCD, one of these with cytophagic histiocytic panniculitis. Mean age at symptom onset was 85 months (6–204 months) and the mean duration of follow up was 55 months (1–144 months). All the patients presented with inflammatory subcutaneous nodules. The patients with WCD presented with systemic manifestations and cutaneous atrophy. The principal etiologies of EN were streptococcal infection (42%), undetermined (13.5%), pulmonary tuberculosis (10%), and acute rheumatic fever (10%). Biopsy of the nodules indicated septal panniculitis in 14 patients with EN and lobular panniculitis without vasculitis in the patients with WCD, one of which had cytophagic histiocytic panniculitis. There was recurrence in 11 patients (38%) with EN and in all those with WCD. Non‐steroidal anti‐inflammatory drugs were used in 15 patients with EN and corticosteroids and/or immunosuppressive drugs in the six patients with WCD. Three patients died. Conclusions: EN is the most frequent panniculitis, with a benign course and is mainly associated with infections. WCD is a severe disease, with systemic involvement, that proceeds with cutaneous atrophy and requires the use of corticosteroids and or immunosuppressive drugs. 相似文献
86.
Trauma und Berufskrankheit - Im vorliegenden Beitrag wird der rehabilitative Ablauf nach einer tiefen queren Schnittverletzung in der proximalen Hohlhand mit Durchtrennung aller... 相似文献
87.
88.
Karl Schaller 《Acta neurochirurgica》2013,155(3):547-547
89.
90.