全文获取类型
收费全文 | 1408679篇 |
免费 | 115800篇 |
国内免费 | 3332篇 |
专业分类
耳鼻咽喉 | 18366篇 |
儿科学 | 46592篇 |
妇产科学 | 41074篇 |
基础医学 | 200810篇 |
口腔科学 | 37748篇 |
临床医学 | 125966篇 |
内科学 | 284194篇 |
皮肤病学 | 33471篇 |
神经病学 | 116901篇 |
特种医学 | 53867篇 |
外国民族医学 | 464篇 |
外科学 | 210705篇 |
综合类 | 32757篇 |
现状与发展 | 3篇 |
一般理论 | 487篇 |
预防医学 | 109962篇 |
眼科学 | 31477篇 |
药学 | 98505篇 |
1篇 | |
中国医学 | 3349篇 |
肿瘤学 | 81112篇 |
出版年
2021年 | 10854篇 |
2019年 | 11670篇 |
2018年 | 16588篇 |
2017年 | 12691篇 |
2016年 | 14289篇 |
2015年 | 16039篇 |
2014年 | 22584篇 |
2013年 | 33433篇 |
2012年 | 45442篇 |
2011年 | 47966篇 |
2010年 | 28188篇 |
2009年 | 27076篇 |
2008年 | 44367篇 |
2007年 | 46864篇 |
2006年 | 47437篇 |
2005年 | 45906篇 |
2004年 | 43796篇 |
2003年 | 41733篇 |
2002年 | 40227篇 |
2001年 | 73025篇 |
2000年 | 74554篇 |
1999年 | 61590篇 |
1998年 | 17002篇 |
1997年 | 15439篇 |
1996年 | 15599篇 |
1995年 | 14803篇 |
1994年 | 13407篇 |
1993年 | 12595篇 |
1992年 | 45850篇 |
1991年 | 43487篇 |
1990年 | 41506篇 |
1989年 | 39567篇 |
1988年 | 36190篇 |
1987年 | 35363篇 |
1986年 | 32874篇 |
1985年 | 31290篇 |
1984年 | 23836篇 |
1983年 | 20026篇 |
1982年 | 12213篇 |
1981年 | 10786篇 |
1979年 | 20706篇 |
1978年 | 14588篇 |
1977年 | 12101篇 |
1976年 | 11377篇 |
1975年 | 11630篇 |
1974年 | 14000篇 |
1973年 | 13537篇 |
1972年 | 12642篇 |
1971年 | 11486篇 |
1970年 | 10923篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
291.
292.
293.
M. Novi C. Vanni P. D. Parchi M. Di Paolo N. Piolanti M. Scaglione 《Musculoskeletal surgery》2020,104(1):43-48
Over the years, the number of total hip replacements has been steadily increasing. Despite the improvement in surgical results, the number of claims for malpractice is higher. The primary endpoint of this work is to provide an analysis of litigation after hip replacement, to outline what are the instigating causes and costs. The secondary endpoint is to propose a possible preventive strategy for an improved care and a reduction in legal proceedings. The data of this study were collected from medical and legal files and from professional liability insurance of our institution from January 2005 to December 2016. Out of a total of 4770 THA, 40 claims were received. Peripheral nerve injuries represent the first cause of litigation (37%), followed by infectious complications, leg length discrepancy, metallosis, dislocations of the implant and a case of deep vein thrombosis. From the analysis of the past trial judgment, complications such as nerve lesions and infections are almost always recognized, as a medical error, with a high percentage of claims settled. This study shows the necessity of preventive strategies to reduce the higher number of claims for malpractice in total hip arthroplasty. Some complications such as nerve injuries and infection are frequently considered directly dependent on physician’s errors. Litigations can be reduced providing evidence of a diligent execution of the surgical procedure and of a proper postoperative management: the correct compilation of a specific informed consent and adequate doctor–patient communication. 相似文献
294.
295.
Andriy
Derkach Steven C. Moore Simina M. Boca Joshua N. Sampson 《Statistics in medicine》2020,39(18):2423-2436
We consider the scenario where there is an exposure, multiple biologically defined sets of biomarkers, and an outcome. We propose a new two-step procedure that tests if any of the sets of biomarkers mediate the exposure/outcome relationship, while maintaining a prespecified familywise error rate. The first step of the proposed procedure is a screening step that removes all groups that are unlikely to be strongly associated with both the exposure and the outcome. The second step adapts recent advances in postselection inference to test if there are true mediators in each of the remaining candidate sets. We use simulation to show that this simple two-step procedure has higher statistical power to detect true mediating sets when compared with existing procedures. We then use our two-step procedure to identify a set of Lysine-related metabolites that potentially mediate the known relationship between increased body mass index and the increased risk of estrogen-receptor positive breast cancer in postmenopausal women. 相似文献
296.
297.
The state of the mother''s immune system during pregnancy has an important role in fetal development and disruptions in the balance of this system are associated with a range of neurologic, neuropsychiatric and neurodevelopmental disorders. Epidemiological and clinical reports reveal various clues that suggest a possible association between developmental neuropsychiatric disorders and family history of immune system dysfunction. Over the past three decades, analogous increases have been reported in both the incidence of neurodevelopmental disorders and immune-related disorders, particularly allergy and asthma, raising the question of whether allergic asthma and characteristics of various neurodevelopmental disorders share common causal links. We used a mouse model of maternal allergic asthma to test this novel hypothesis that early fetal priming with an allergenic exposure during gestation produces behavioral deficits in offspring. Mothers were primed with an exposure to ovalbumin (OVA) before pregnancy, then exposed to either aerosolized OVA or vehicle during gestation. Both male and female mice born to mothers exposed to aerosolized OVA during gestation exhibited altered developmental trajectories in weight and length, decreased sociability and increased marble-burying behavior. Moreover, offspring of OVA-exposed mothers were observed to have increased serotonin transporter protein levels in the cortex. These data demonstrate that behavioral and neurobiological effects can be elicited following early fetal priming with maternal allergic asthma and provide support that maternal allergic asthma may, in some cases, be a contributing factor to neurodevelopmental disorders. 相似文献
298.
Grulois Daphné Tiavouane Josina Dumas Pascal Paul Fauvelot Cécile 《Conservation Genetics Resources》2015,7(1):73-75
Conservation Genetics Resources - Fifteen polymorphic microsatellite markers were developed for Tridacna maxima in order to assess self-recruitment and larval dispersal within and among MPAs in New... 相似文献
299.
Sirt5 is known to functionally regulate mitochondrial proteins by altering posttranslational modifications, including lysine desuccinylation. While roles for Sirt5 as either a tumor promoter or suppressor, or in chemoresistance, have been implicated in other cancers, the function of Sirt5 in cutaneous melanoma has not been well examined. Therefore, to determine whether Sirt5 is necessary for BrafV600E‐mediated melanoma formation and/or disease progression, we crossed a genetically engineered murine melanoma model (TyrCreERT2/+; BrafLSL‐V600E/+; Ptenflox/flox) to Sirt5?/? knockout animals. In addition, we tested for synergism with a selective BRAF (V600E) inhibitor in Sirt5?/? mouse melanoma cells. Taken together, this report demonstrates that, in these models, Sirt5 is dispensable for BrafV600E‐mediated cutaneous melanoma formation and growth in vivo, and does not improve sensitivity to a selective BRAF inhibitor. 相似文献