全文获取类型
收费全文 | 300篇 |
免费 | 27篇 |
国内免费 | 8篇 |
专业分类
耳鼻咽喉 | 1篇 |
儿科学 | 17篇 |
妇产科学 | 1篇 |
基础医学 | 36篇 |
口腔科学 | 2篇 |
临床医学 | 22篇 |
内科学 | 57篇 |
皮肤病学 | 4篇 |
神经病学 | 11篇 |
特种医学 | 75篇 |
外科学 | 27篇 |
综合类 | 7篇 |
预防医学 | 31篇 |
眼科学 | 5篇 |
药学 | 17篇 |
中国医学 | 1篇 |
肿瘤学 | 21篇 |
出版年
2022年 | 2篇 |
2021年 | 6篇 |
2020年 | 3篇 |
2019年 | 5篇 |
2018年 | 8篇 |
2017年 | 7篇 |
2016年 | 4篇 |
2015年 | 10篇 |
2014年 | 7篇 |
2013年 | 11篇 |
2012年 | 6篇 |
2011年 | 7篇 |
2010年 | 15篇 |
2009年 | 16篇 |
2008年 | 8篇 |
2007年 | 17篇 |
2006年 | 11篇 |
2005年 | 11篇 |
2004年 | 3篇 |
2003年 | 9篇 |
2002年 | 5篇 |
2001年 | 6篇 |
2000年 | 5篇 |
1999年 | 6篇 |
1998年 | 19篇 |
1997年 | 15篇 |
1996年 | 9篇 |
1995年 | 7篇 |
1994年 | 10篇 |
1993年 | 8篇 |
1992年 | 2篇 |
1991年 | 2篇 |
1990年 | 3篇 |
1989年 | 4篇 |
1988年 | 6篇 |
1987年 | 4篇 |
1986年 | 8篇 |
1985年 | 5篇 |
1981年 | 2篇 |
1980年 | 7篇 |
1978年 | 2篇 |
1976年 | 3篇 |
1975年 | 2篇 |
1971年 | 2篇 |
1970年 | 2篇 |
1968年 | 2篇 |
1940年 | 2篇 |
1939年 | 4篇 |
1931年 | 4篇 |
1930年 | 3篇 |
排序方式: 共有335条查询结果,搜索用时 15 毫秒
61.
Mulligan JD Schmuck EG Ertel RL Brellenthin AG Bauwens JD Saupe KW 《Age (Dordrecht, Netherlands)》2011,33(3):351-361
The aged heart displays a loss of cardiomyocyte number and function, possibly due to the senescence and decreased regenerative
potential that has been observed in some cardiac progenitor cells. An important cardiac progenitor that has not been studied
in the context of aging is the cardiac side population (CSP) cell. To address this, flow cytometry-assisted cell sorting was
used to isolate CSP cells from adult (6–10 months old) and aged (24–32 months old) C57Bl/6 mice that were fed either a control
diet or an anti-aging diet (caloric restriction, CR). Aging caused a 2.3-fold increase in the total number of CSP cells and
a 3.2-fold increase in the cardiomyogenic sca1+/CD31− subpopulation. Aging did not affect markers of proliferation or senescence, including telomerase activity and expression
of cell cycle genes, in sca1+/CD31− CSP cells. In contrast, the aged cells had reduced expression of genes associated with differentiation, including smooth
muscle actin and cardiac muscle actin (5.1- and 3.2-fold, respectively). None of these age effects were altered by CR diet.
Therefore, it appears that the manner in which CSP cells age is distinct from the aging of post-mitotic tissue (and perhaps
other progenitor cells) that can often be attenuated by CR. 相似文献
62.
63.
Pc Ng Ch Lee KF To TF Fok KW So W Wong & KL Cheung 《Journal of paediatrics and child health》1999,35(3):306-308
A severe case of aplasia cutis congenita in a preterm infant is described. Although major problems with thermoregulation and fluid balance were anticipated, these parameters were relatively easy to control once the patient was stabilized. Meticulous skin care and rapid formation of a membranous-like fibrous tissue layer covering the denuded areas probably played an important role in minimizing excessive fluid and heat loss. The prognosis in aplasia cutis congenita is determined by the underlying associated anomalies, the severity of skin lesions and, in our case, the maturity of the infant who died from complications of prematurity. 相似文献
64.
DK Ng KW Chau C Black TMM Thomas KL Mak & M Boxer 《Journal of paediatrics and child health》1999,35(3):321-323
A case of neonatal Marfan syndrome is presented. The patient was noted to have cardiomegaly and tricuspid regurgitation on antenatal ultrasound scan. She was born with long, slender fingers and toes, an aged appearance and non-paralytic hypotonia. Echocardiogram revealed a dilated right atrium, right ventricle, dysplastic tricuspid valve and severe tricuspid regurgitation. She subsequently died of severe heart failure. Post-mortem examination showed the pathological features of lobar emphysema and cystic medial necrosis of the aorta. These features supported the diagnosis of neonatal Marfan syndrome. Nucleotide sequencing showed substitution of G by A at codon 1032 in exon 25 located in the long arm of chromosome 15. This resulted in the substitution of a cysteine by a tyrosine. A de novo mutation is suggested by the absence of affected family members. 相似文献
65.
66.
67.
Tobias Johannes Dietrich Marco Zanetti Nadja Saupe Christian W. A. Pfirrmann Sandro F. Fucentese Juerg Hodler 《Skeletal radiology》2010,39(5):473-480
Objective
To evaluate the diagnostic performance of MR arthrography in the detection of articular cartilage and labral lesions of the glenohumeral joint using a transverse 3D water-excitation true fast imaging with steady-state precession (FISP) sequence. 相似文献68.
69.
70.
目的在甲状腺手术中缺少术中神经监测(intra operative neuromonitoring,IONM)的标准化操作可导致结果变异性强,这些结果可产生错误信息并增加喉返神经损伤的危险性。因此有必要进行IONM操作的标准化。方法本研究共招募了289例进行过甲状腺切除术的患者(435根神经有危险),均由一位外科医师实施手术。每例患者均由同一位麻醉师使用EMG气管导管进行插管。每例患者均进行标准化IONM操作。该操作包括术前和术后对声带运动进行录像监测、保证电极在正确位置、喉返神经剥离前后刺激迷走神经并记录EMG信号,并摄像记录暴露的喉返神经。结果5例患者出现IONM波形异常,是由于电极错位所致,这一问题被立刻监测到。监测到1例患者在手术较早阶段出现非喉返神经损伤。甲状腺剥离时18例患者的神经失去了EMG信号,使用我们的标准化IONM操作后神经损伤的原因得以清楚阐明。结论标准化IONM操作不仅在消除错误的IONM结果方面有用且有帮助,而且有助于阐明喉返神经损伤的机制。在确定外科手术的缺陷并提高外科手术技巧后,本研究显著降低了神经麻痹的发生率。 相似文献