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331.
Exercise intolerance during post-MI heart failure in rats: prevention with supplemental dietary propionyl-L-carnitine 总被引:1,自引:0,他引:1
Koh SG Brenner DA Korzick DH Tickerhoof MM Apstein CS Saupe KW 《Cardiovascular drugs and therapy / sponsored by the International Society of Cardiovascular Pharmacotherapy》2003,17(1):7-14
Exercise capacity in patients with several types of cardiovascular disease can be improved with dietary carnitine, or carnitine derivatives. Mechanisms underlying this improvement remain largely unknown in part due to a lack of animal models of cardiac pathology in which carnitine derivatives improve exercise tolerance. Our goal was to evaluate the ability of propionyl-L-carnitine (PLC) to improve exercise tolerance in a rat model of exercise intolerance. Fischer 344 rats were followed after either a moderate size MI (n = 22) or sham MI surgery (n = 14). Starting 10 days post-surgery 10 of the MI and 7 of the sham rats received 100 mg/kg/day PLC in drinking water, which increased plasma and LV total l-carnitine concentrations 15–23% (p < 0.05). Rats were followed longitudinally until a statistically significant decrease in exercise capacity occurred in one of the groups, at which time all rats were sacrificed for study of the isolated perfused hearts. At 12-weeks post-MI exercise capacity had decreased 16 ± 7% (p < 0.05) in the MI group, but remained within 3% of baseline in the MI group that received PLC and the sham groups. Both MI groups exhibited the same degree of LV dilation, decrease in fractional shortening, and blunting of the response to isoproterenol. We conclude that supplemental dietary PLC attenuates the exercise intolerance that occurs secondary to post-MI heart failure in rats, but that this beneficial effect is not attributable to altered LV remodeling, an improved response to -adrenergic stimulation, or increased skeletal muscle citrate synthase activity. 相似文献
332.
Drossaers-Bakker KW; Hamburger HL; Bongartz EB; Dijkmans BA; Van Soesbergen RM 《Rheumatology (Oxford, England)》1998,37(8):889-894
Sleep apnoea syndrome (SAS) is a rarely documented, but possibly lethal,
complication of the instability of the cervical spine in rheumatoid
arthritis. Five patients with SAS of a central or peripheral origin are
presented, and the problems of recognizing and diagnosing the syndrome are
discussed. We hope that clinicians will become more aware of the existence
and the different aetiologies of SAS, thus improving early recognition and
appropriate treatment. Adequate treatment has proven to increase survival
in peripheral SAS and seems to be successful in doing so in central SAS.
相似文献
333.
The effect on patient exposure of x-ray filters made of heavy elements has been studied in excretory urography and lumbar spine examinations. Several elements with atomic numbers between 62 and 74 were tested in experiments using radiographic phantoms and in patient studies. A holmium filter reduced skin exposure by more than 50% in excretory urography. Similar results were obtained with ytterbium and tungsten in lumbar spine studies. 相似文献
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