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261.
Surgery for synchronous colorectal cancers with double colonic anastomoses: A comparison of laparoscopic and open approaches 下载免费PDF全文
262.
Shigehisa Aoki MD Toshiaki Takezawa PhD Satoshi Ikeda MS Yutaka Narisawa MD Ayumi Oshikata‐Miyazaki PhD Syohei Miyauchi MS Hiroshi Hirayama BS Tomoya Sawaguchi MS Tomoyuki Chimuro MS Shuji Toda MD 《Wound repair and regeneration》2015,23(6):819-829
Engineered skin substitutes are widely used in skin wound management. However, no currently available products satisfy all the criteria of usability in emergency situations, easy handling, and minimal scar formation. To overcome these shortcomings, we designed a cell‐free bandage‐type artificial skin, named “VitriBand” (VB), using adhesive film dressing, silicone‐coated polyethylene terephthalate film, and collagen xerogel membrane defined as a dried collagen vitrigel membrane without free water. We analyzed its advantages over in‐line products by comparing VB with hydrocolloid dressing and collagen sponge. For evaluation, mice inflicted with full‐thickness skin defects were treated with VB, hydrocolloid dressing, and collagen sponge. A plastic film group treated only with adhesive film dressing and silicone‐coated polyethylene terephthalate film, and a no treatment group were also compared. VB promoted epithelization while inhibiting the emergence of myofibroblasts and inflammation in the regenerating tissue more effectively than the plastic film, hydrocolloid dressing, and collagen sponge products. We have succeeded in establishing a cell‐free bandage‐type artificial skin that could serve as a promising first‐line medical biomaterial for emergency treatment of skin injuries in various medical situations. 相似文献
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Yoshihiro Sudo Yoichi Ezura Ryota Ishida Mitsuko Kajita Hideyo Yoshida Takao Suzuki Takayuki Hosoi Satoshi Inoue Masataka Shiraki Hajime Orimo Hiromoto Ito Mitsuru Emi 《Geriatrics & Gerontology International》2004,4(4):245-249
Background: Osteoporosis is believed to result from the interaction among multiple environmental and genetic determinants that regulate bone-mineral density (BMD).
Methods: To investigate a potentially predisposing genetic factor in the onset of osteoporosis, we looked for a possible association between BMD in adult Japanese women and known polymorphisms in the leukemia inhibitory factor receptor gene (LIFR).
Results: An association analysis of chromosomes from 384 volunteer subjects revealed significant correlation between the −603T > C variant of LIFR and radial BMD ( r = 0.11, P = 0.032) in this test population. Comparisons of mean values of adjusted radial BMD among separate genotypic groups implied an allelic dosage effect, because homozygous carriers of T alleles of that SNP had the highest adjusted BMDs (0.403 ± 0.054 g/cm2 ); women homozygous for the C-allele had the lowest (0.373 ± 0.042 g/cm2 ), and heterozygous individuals had intermediate scores (0.394 ± 0.056 g/cm2 ).
Conclusion: This polymorphism in LIFR may be an important determinant of predisposition to postmenopausal osteoporosis. 相似文献
Methods: To investigate a potentially predisposing genetic factor in the onset of osteoporosis, we looked for a possible association between BMD in adult Japanese women and known polymorphisms in the leukemia inhibitory factor receptor gene (LIFR).
Results: An association analysis of chromosomes from 384 volunteer subjects revealed significant correlation between the −603T > C variant of LIFR and radial BMD ( r = 0.11, P = 0.032) in this test population. Comparisons of mean values of adjusted radial BMD among separate genotypic groups implied an allelic dosage effect, because homozygous carriers of T alleles of that SNP had the highest adjusted BMDs (0.403 ± 0.054 g/cm
Conclusion: This polymorphism in LIFR may be an important determinant of predisposition to postmenopausal osteoporosis. 相似文献
265.
Hirata N Kushida Y Ohguri T Wakasugi S Kojima T Fujita R 《Journal of gastroenterology》1999,34(6):713-716
We present a patient with complication of huge hepatic subcapsular hematoma after extracorporeal shock wave lithotripsy (ESWL)
for pancreatic lithotripsy. The hematoma measured 78–110 mm. Angiography showed a subcapsular hematoma, rather than a hematoma
in the liver. In the arterial phase, the distal end of the small vessel showed spotty opacification similar to microaneurysma,
suggesting that it was an injury caused by separation of the liver and its capsule, caused by the shock waves. The portal
vein and hepatic vein were normal. After 8 weeks of conservative therapy, the hematoma was gradually absorbed and the patient
was discharged. Eight months after the accident, the hematoma had decreased to 40 mm in size. After 20 months, it was completely
absorbed. The reported rate of renal subcapsular hematoma after ESWL for renal or ureter stones is 0.1%–0.7%. To date, however,
only five cases of hepatic subcapsular hematoma after right renal stone disintegration have been reported. This is the first
report of hepatic subcapsular hematoma after ESWL for pancreatic stones.
Received: September 11, 1998 / Accepted: April 16, 1999 相似文献
266.
Dr. Toshiyuki Matsui M.D. Ph.D. Nobuaki Hayashi M.D. Kenshi Yao M.D. Ph.D. Tsuneyoshi Yao M.D. Ph.D. Kuniaki Takenaka M.D. Ph.D. Toshio Hoashi M.D. Ph.D. Satoshi Takemura M.D. Ph.D. Akinori Iwashita M.D. Ph.D. Akira Tanaka M.D. Ph.D. Mitsuru Koga M.D. Ph.D. 《Diseases of the colon and rectum》1998,41(6):797-801
Typical Turcot's syndrome is characterized by the association of a brain glioma together with multiple colonic polyposis, in which the number of polypoid lesions is small and the association of colonic cancer occurs at a younger age than in familial adenomatous polyposis. We describe a family in which both the father and his son presented with typical Turcot's syndrome without parental consanguinity. This is the first report of a family that is considered to follow an autosomal dominant inheritance. After reviewing 25 documented cases in which the average age of death was 20.3 years old, it was learned that the major cause of death was brain tumor (76 percent) and the minor cause was colon cancer (16 percent). Patients were very young and, therefore, unlikely to have produced a child before their death. These facts seem to support the theory that Turcot's syndrome is an autosomal dominant disorder. 相似文献
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Infection with hepatitis B virus genotype A in Tokyo, Japan during 1976 through 2001 总被引:1,自引:0,他引:1
Kobayashi M Suzuki F Arase Y Akuta N Suzuki Y Hosaka T Saitoh S Kobayashi M Tsubota A Someya T Ikeda K Matsuda M Sato J Kumada H 《Journal of gastroenterology》2004,39(9):844-850
Background Because genotype A of hepatitis B virus (HBV) is not indigenous, there have been only few data on infection with it in Japan.Methods We examined clinical and virological features of the 66 Japanese patients who admitted Toranomon Hospital in Tokyo, Japan, between 1976 and 2001, who were found to have HBV/A infection. HBV genotype A was classified into subtype A (European type) and A (South African type) by phylogenetic analysis of the preS1 and preS2 regions, and the S gene sequences.Results Of the 66 patients infected with HBV/A, 14 (21%) were asymptomatic carriers, 26 (39%) presented with acute hepatitis, 22 (33%) with chronic hepatitis, and 4 (6%) with liver cirrhosis. HBV/A infection persisted for more than 6 months in 5 of the 26 (19%) patients with acute hepatitis. The frequency of acute hepatitis in patients infected with HBV/A was higher after than before 1991 (2/22 [9%] vs 24/44 [55%]; P < 0.0001). The frequency of nucleotide 1858 of T was higher in asymptomatic carriers than in patients with acute hepatitis in whom infection was resolved (5/14 [36%] vs 0/21 [0%]; P = 0.008). Of the 57 patients for whom subtypes of genotype A were determined, subtype A was identified in 53 (93%) and subtype A in only 4 (7%). All patients infected with subtype A were persistently infected with HBV.Conclusions HBV/A infection has become more frequent during recent years, predominantly presenting as acute hepatitis, and subtype A is uncommon in the Tokyo metropolitan area. 相似文献
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