全文获取类型
收费全文 | 7476篇 |
免费 | 350篇 |
国内免费 | 73篇 |
专业分类
耳鼻咽喉 | 72篇 |
儿科学 | 127篇 |
妇产科学 | 158篇 |
基础医学 | 830篇 |
口腔科学 | 134篇 |
临床医学 | 463篇 |
内科学 | 1994篇 |
皮肤病学 | 154篇 |
神经病学 | 450篇 |
特种医学 | 264篇 |
外科学 | 1493篇 |
综合类 | 18篇 |
一般理论 | 1篇 |
预防医学 | 186篇 |
眼科学 | 187篇 |
药学 | 354篇 |
中国医学 | 14篇 |
肿瘤学 | 1000篇 |
出版年
2024年 | 6篇 |
2023年 | 58篇 |
2022年 | 105篇 |
2021年 | 198篇 |
2020年 | 116篇 |
2019年 | 137篇 |
2018年 | 211篇 |
2017年 | 146篇 |
2016年 | 166篇 |
2015年 | 198篇 |
2014年 | 249篇 |
2013年 | 313篇 |
2012年 | 534篇 |
2011年 | 615篇 |
2010年 | 344篇 |
2009年 | 301篇 |
2008年 | 552篇 |
2007年 | 566篇 |
2006年 | 500篇 |
2005年 | 490篇 |
2004年 | 448篇 |
2003年 | 448篇 |
2002年 | 387篇 |
2001年 | 66篇 |
2000年 | 48篇 |
1999年 | 65篇 |
1998年 | 101篇 |
1997年 | 63篇 |
1996年 | 64篇 |
1995年 | 43篇 |
1994年 | 55篇 |
1993年 | 38篇 |
1992年 | 32篇 |
1991年 | 22篇 |
1990年 | 17篇 |
1989年 | 21篇 |
1988年 | 29篇 |
1987年 | 19篇 |
1986年 | 10篇 |
1985年 | 8篇 |
1984年 | 15篇 |
1983年 | 12篇 |
1982年 | 14篇 |
1981年 | 12篇 |
1980年 | 8篇 |
1978年 | 13篇 |
1977年 | 10篇 |
1976年 | 3篇 |
1975年 | 7篇 |
1974年 | 3篇 |
排序方式: 共有7899条查询结果,搜索用时 93 毫秒
81.
82.
Katia Herz Alexandra Becker Chenyue Shi Masatsugo Ema Satoru Takahashi Michael Potente Michael Hesse Bernd K. Fleischmann Daniela Wenzel 《Angiogenesis》2018,21(2):349-361
Endothelial cell proliferation is a key process during vascular growth but its kinetics could only be assessed in vitro or ex vivo so far. To enable the monitoring and quantification of cell cycle kinetics in vivo, we have generated transgenic mice expressing an eGFP-anillin construct under control of the endothelial-specific Flt-1 promoter. This construct labels the nuclei of endothelial cells in late G1, S and G2 phase and changes its localization during the different stages of M phase, thereby enabling the monitoring of EC proliferation and cytokinesis. In Flt-1/eGFP-anillin mice, we found eGFP+ signals specifically in Ki67+/PECAM+ endothelial cells during vascular development. Quantification using this cell cycle reporter in embryos revealed a decline in endothelial cell proliferation between E9.5 to E12.5. By time-lapse microscopy, we determined the length of different cell cycle phases in embryonic endothelial cells in vivo and found a M phase duration of about 80 min with 2/3 covering karyokinesis and 1/3 cytokinesis. Thus, we have generated a versatile transgenic system for the accurate assessment of endothelial cell cycle dynamics in vitro and in vivo. 相似文献
83.
Tomohisa Furuya Satoru Sugimoto Chie Kurokawa Shuichi Ozawa Kumiko Karasawa Keisuke Sasai 《Journal of radiation research》2013,54(1):157-165
To evaluate the dosimetric impact of respiratory breast motion and daily setup error on whole breast irradiation (WBI) using three irradiation techniques; conventional wedge (CW), field-in-field (FIF) and irregular surface compensator (ISC). WBI was planned for 16 breast cancer patients. The dose indices for evaluated clinical target volume (CTVevl), lung, and body were evaluated. For the anterior-posterior (AP) respiratory motion and setup error of a single fraction, the isocenter was moved according to a sine function, and the dose indices were averaged over one period. Furthermore, the dose indices were weighted according to setup error frequencies that have a normal distribution to model systematic and random setup error for the entire treatment course. In all irradiation techniques, AP movement has a significant impact on dose distribution. CTVevlD95 (the minimum relative dose that covers 95 % volume) and V95 (the relative volume receiving 95 % of the prescribed dose) were observed to significantly decrease from the original ISC plan when simulated for the entire treatment course. In contrast, the D95, V95 and dose homogeneity index did not significantly differ from those of the original plans for FIF and CW. With regard to lung dose, the effect of motion was very similar among all three techniques. The dosimetric impact of AP respiratory breast motion and setup error was largest for the ISC technique, and the second greatest effect was observed with the FIF technique. However, these variations are relatively small. 相似文献
84.
Hiroki Tojima Satoru Kakizaki Takashi Kosone Norio Horiguchi Yuichi Yamazaki Ken Sato Hitoshi Takagi Masatomo Mori 《Hepatology International》2012,6(3):620-630
Background
Hepatocyte growth factor (HGF) is a potent growth factor involved in liver regeneration that has various effects on epithelial and nonepithelial cells. Although it has been demonstrated that HGF can reduce liver inflammation or fibrosis caused by pharmaceutical or chemical insult, no examination of its effect on liver injury in nonalcoholic steatohepatitis (NASH) has been reported. 相似文献85.
86.
87.
Manabu Yanagita Kenta Mori Ryohei Kobayashi Yuko Kojima Mikiko Kubota Koji Miki Satoru Yamada Masahiro Kitamura Shinya Murakami 《European journal of oral sciences》2012,120(5):408-414
Tobacco smoking is a significant risk factor for periodontal diseases. Nicotine, one of the most studied constituents in cigarette smoke, is thought to modify immune responses. Dendritic cells (DCs), which are key mediators between innate and adaptive immunity, stimulate naive T cells to differentiate to effector T‐cell subsets that may be actively involved in the immunopathogenesis of periodontal diseases. In this study, we evaluated the effects of nicotine and lipopolysaccharide (LPS) from Porphyromonas gingivalis, alone and in combination, on the functions of human monocyte‐derived DCs to elucidate the mechanism of tissue destruction of smoking‐associated periodontal diseases. P. gingivalis LPS‐stimulated DCs differentiated with nicotine (NiDCs) induced lower T‐cell proliferation and human leukocyte antigen (HLA)‐DR expression, but elevated expression of programmed cell death ligand 1. Additionally, NiDCs impaired interferon‐γ production but maintained interleukin (IL)‐5 and IL‐10 production in co‐cultured T cells. Furthermore, NiDCs produced lower levels of proinflammatory cytokines compared with DCs differentiated in the absence of nicotine. Interestingly, NiDCs preferentially produced the T helper 2 (Th2)‐type chemokines macrophage chemotactic protein‐1 and macrophage‐derived chemokine. These results suggest that the presence of nicotine during differentiation of DCs modulates the immunoregulatory functions of P. gingivalis LPS‐stimulated DCs. 相似文献
88.
Dipeptidyl peptidase‐4 inhibitors as preferable oral hypoglycemic agents in terms of treatment satisfaction: Results from a multicenter, 12‐week,open label,randomized controlled study in Japan (PREFERENCE 4 study)
下载免费PDF全文
![点击此处可从《Journal of diabetes investigation.》网站下载免费的PDF全文](/ch/ext_images/free.gif)
89.
Epidermal aspects of type VII collagen: Implications for dystrophic epidermolysis bullosa and epidermolysis bullosa acquisita
下载免费PDF全文
![点击此处可从《The Journal of dermatology》网站下载免费的PDF全文](/ch/ext_images/free.gif)
Mika Watanabe Ken Natsuga Satoru Shinkuma Hiroshi Shimizu 《The Journal of dermatology》2018,45(5):515-521
Type VII collagen (COL7), a major component of anchoring fibrils in the epidermal basement membrane zone, has been characterized as a defective protein in dystrophic epidermolysis bullosa and as an autoantigen in epidermolysis bullosa acquisita. Although COL7 is produced and secreted by both epidermal keratinocytes and dermal fibroblasts, the role of COL7 with regard to the epidermis is rarely discussed. This review focuses on COL7 physiology and pathology as it pertains to epidermal keratinocytes. We summarize the current knowledge of COL7 production and trafficking, its involvement in keratinocyte dynamics, and epidermal carcinogenesis in COL7 deficiency and propose possible solutions to unsolved issues in this field. 相似文献
90.