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91.
Satapathy J Kar BR Job CK 《Indian journal of dermatology, venereology and leprology》2005,71(4):267-269
A 49-year-old man with lepromatous leprosy treated with dapsone monotherapy for 12 years (1967 to 1979) reported in the hospital in 2003, with relapsed disease. A slit skin smear showed a bacteriological index of 4+. Biopsies from skin lesions before and after anti-leprosy therapy showed features of lepromatous leprosy. Both biopsies showed unusual features of bacillary clumps in epidermal cells demonstrating clearly that dissemination of M. leprae can take place even through unbroken skin. The presence of lepra bacilli in clumps in the epidermis is an indicator that the skin is a potential route of transmission of the disease. 相似文献
92.
JK Gass SK Chan E Rytina DC Greenberg NP Burrows 《Journal of the European Academy of Dermatology and Venereology》2010,24(5):601-603
Background Merkel cell carcinoma (MCC) is a rare malignant cutaneous tumour, the incidence of which is increasing. Second malignancies have been reported to occur with high incidence in these patients. Objectives We report the rate and nature of multiple malignancies in patients with MCC treated over a 10 year period in Addenbrooke’s Hospital in Cambridge, United Kingdom, as well as the temporal relationship of these additional malignancies to the diagnosis of MCC. Results The 27 patients had an approximately equal sex incidence with a median age at diagnosis of 79 years. Seventy percent (n=19) of patients had a second primary malignant tumour; and 7 of these patients had two or more tumours in addition to the MCC. Eighteen patients had additional cutaneous malignancies: melanoma, squamous cell carcinoma and basal cell carcinoma, and 8 patients presented non‐cutaneous malignancy including colorectal, haematological and breast tumours. Of the 28 additional tumours in our patients, half were diagnosed prior to presentation of MCC, 32% within 6 months of diagnosis, and 18% between 6 months and 3 years after diagnosis. Possible reasons for the high rate of additional tumours in this population are discussed. Conclusions Our figures reflect a higher incidence of multiple malignancies in those with Merkel cell tumour than has previously been reported. This has important implications for the care and surveillance of these patients. 相似文献
93.
SK Ghosh D Bandyopadhyay A Ghosh 《Journal of the European Academy of Dermatology and Venereology》2010,24(2):214-218
Background Symmetrical peripheral gangrene (SPG) is characterized by sudden onset of peripheral, frequently symmetrical gangrene in the absence of major vascular occlusive disease. SPG is associated with a wide range of underlying medical problems and usually has disseminated intravascular coagulation (DIC) in the background. Although sporadic cases and a few retrospective case series of SPG have been reported, lack of any prospective study on the profile and outcome of these patients prompted us to undertake the present work. Objectives To study the clinical profile, aetiological factors, and outcome of a group of patients of SPG from eastern India. Patients/methods Prospective, observational study of consecutive patients presented at or referred to the Dermatology Department of a tertiary‐care hospital during 2001 to 2008. Results We observed 14 patients (5 males, 9 females; mean age: 43.36 years) of SPG during the study period. All had clinical and laboratory evidence of DIC in association with a shock syndrome. Associated purpura fulminans was noted in 11 patients. In 12 patients, the cause of SPG was infective, Pneumococcus being the commonest organism involved. Two patients developed DIC and SPG postoperatively. Nine patients survived and the remaining five patients died. Three patients had leukopenia and all of them died. Amongst the survivors, four patients had auto‐amputation of some parts of distal limbs; surgical amputation was done in two patients. Conclusions SPG carries a high mortality rate frequently requiring multiple limb amputations in survivors. Leukopenia may be a poor prognostic factor of SPG and DIC may occur universally. 相似文献
94.
95.
The right mid-lung window 总被引:1,自引:0,他引:1
Goodman LR; Golkow RS; Steiner RM; Teplick SK; Haskin ME; Himmelstein E; Teplick JG 《Radiology》1982,143(1):135
96.
Aneurysm of sinus of Valsalva dissecting into interventricular septum is a rare entity. We report one such case who was incidentally diagnosed by echocardiography to have this abnormality during evaluation of a clinically suspected isolated aortic regurgitation.KEY WORDS: Aneurysm – dissecting – sinus of Valsalva, Echocardiography 相似文献
97.
B Airan Ch SK Choudhary M. Ch CSK Ready M. Ch A Saxena DM SS Kothari DM IM Rao M.Ch P Venugopal M.Ch 《Indian Journal of Thoracic and Cardiovascular Surgery》2000,16(1):15-18
Introduction The Fontan procedure has undergone many modifications to avoid atrial arrhythmias and thrombus formation. We used patient’s
interatrial septum as a flap to direct the inferior venacaval blood to the superior venacava.
Methods Seventeen patients, aged 1 to 17 years, underwent modified total cavopulmonary anastomosis. Interatrial septum was used to
create the inner half of the atrial tunnel, outer half being formed by right atrial free wall. Post-operatively, all patients
underwent echocardiography. Seven patients underwent 24 hour ambulatory Holter monitoring and 6 patients underwent cardiac
catheterization and cineangiography.
Results There was one early death due to low cardiac output. One patient had transient supraventricular arrhythmia. Two patients had
singnificant pleural effusion. Holter Monitoring reveled sinus rhythm in all 7 patients studied. Follow up ranged from 18
to 60 months and patients were evaluated as they came for follow up. Long term follow up is currently being compiled. There
was one late death from a non-cardiac cause. The remaining patients were in New York Heart Association (NYHA) Class I or II.
All patients were in sinus rhythm. Echocardiography and cineangiography revealed absence of obstruction or leak.
Conclusions Total cavopulmonary anastomosis using autogenous atrial septum is a useful modification for classical cavopulmonary anastomosis
and provides good early results. 相似文献
98.
目的 了解不同的心肌保护方法是否对体外循环 (ECC)术后房性心律失常有影响。 方法 将 12只成年杂交犬随机分为两组 ,A组 :6只犬 ,用持续温血心脏停搏液灌注 ;B组 :6只犬 ,用冷晶体心脏停搏液灌注和局部低温。两组动物主动脉阻断时间均为 30分钟。记录术前及术后 1~ 5天 2 4小时动态心电图 ,计算标准化房性心律失常 ,标准化室性心律失常和 2 4小时平均心率。 结果 ECC后两组动物均未出现心房颤动。尽管术后 A组标准化房性心律失常率高于 B组 (P<0 .0 5 ) ,但两组动物术前、术后标准化房性心律失常率无明显变化 ,标准化室性心律失常率亦无明显变化。此外 ,两组动物术后 2 4小时平均心率亦升高 ,且 B组高于 A组 (P<0 .0 5 )。 结论 不同的心肌保护方法对 ECC术后房性心律失常的发生无明显影响。 相似文献
99.
100.