全文获取类型
收费全文 | 148964篇 |
免费 | 31957篇 |
国内免费 | 2392篇 |
专业分类
耳鼻咽喉 | 5154篇 |
儿科学 | 5394篇 |
妇产科学 | 2387篇 |
基础医学 | 2961篇 |
口腔科学 | 1470篇 |
临床医学 | 26541篇 |
内科学 | 47003篇 |
皮肤病学 | 7416篇 |
神经病学 | 14641篇 |
特种医学 | 6314篇 |
外科学 | 40785篇 |
综合类 | 259篇 |
现状与发展 | 72篇 |
预防医学 | 6995篇 |
眼科学 | 3328篇 |
药学 | 926篇 |
中国医学 | 15篇 |
肿瘤学 | 11652篇 |
出版年
2024年 | 684篇 |
2023年 | 4788篇 |
2022年 | 1197篇 |
2021年 | 3079篇 |
2020年 | 6011篇 |
2019年 | 2143篇 |
2018年 | 7352篇 |
2017年 | 7315篇 |
2016年 | 8393篇 |
2015年 | 8376篇 |
2014年 | 15450篇 |
2013年 | 15561篇 |
2012年 | 5372篇 |
2011年 | 5381篇 |
2010年 | 10299篇 |
2009年 | 14193篇 |
2008年 | 5700篇 |
2007年 | 3926篇 |
2006年 | 6396篇 |
2005年 | 3665篇 |
2004年 | 2948篇 |
2003年 | 1922篇 |
2002年 | 2026篇 |
2001年 | 3772篇 |
2000年 | 2988篇 |
1999年 | 3190篇 |
1998年 | 3632篇 |
1997年 | 3452篇 |
1996年 | 3354篇 |
1995年 | 3204篇 |
1994年 | 1936篇 |
1993年 | 1560篇 |
1992年 | 1372篇 |
1991年 | 1405篇 |
1990年 | 1052篇 |
1989年 | 1172篇 |
1988年 | 1011篇 |
1987年 | 849篇 |
1986年 | 883篇 |
1985年 | 711篇 |
1984年 | 546篇 |
1983年 | 520篇 |
1982年 | 523篇 |
1981年 | 409篇 |
1980年 | 365篇 |
1979年 | 306篇 |
1978年 | 330篇 |
1977年 | 397篇 |
1975年 | 278篇 |
1972年 | 304篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
991.
Dr Gerald A. Maccioli MD Daniel R. Kuni MS George Silvay MD PhD John M. Evans MB Jerry M. Calkins MD PhD Joel A. Kaplan MD 《Journal of clinical monitoring and computing》1988,4(4):247-255
A multiple-center study was performed to determine the relationship between lower esophageal contractility, clinical signs, and anesthetic concentration as expressed by minimum alveolar concentration (MAC). One hundred four American Society of Anesthesiologists Class I through III patients were exposed to isoflurane (with and without nitrous oxide) or halothane in concentrations of 0.5, 1.0, and 1.5 MAC. Heart rate and systolic blood pressure were continuously monitored. Both the amplitude and frequency of spontaneous and provoked lower esophageal contractions were measured in situ by using a 24-F probe equipped with provoking and measuring balloons. Combined results demonstrated statistically significant correlations (P<0.001) between lower esophageal contractility and MAC. Spontaneous lower esophageal contractions decreased from 1.10±0.12 (SEM) contractions per minute (0.5 MAC) to 0.42±0.05 (1 MAC) to 0.18±0.05 (1.5 MAC). Provoked lower esophageal contractility values decreased from 45±4 mm Hg (0.5 MAC) to 29±3 (1 MAC) to 19±2 (1.5 MAC). Heart rate changes did not correlate with MAC, and systolic blood pressure correlated in only one of three centers. Intracenter and intercenter analyses failed to demonstrate a significant relationship between lower esophageal contractility and heart rate or systolic blood pressure. No intracenter differences in either amplitude or frequency of lower esophageal contractions were observed, despite differences in volatile agents, induction techniques and agents, patient populations, and duration of anesthesia. Our studies indicate that lower esophageal contractility may be an indicator of anesthetic depth as reflected by MAC, but further studies are needed to quantify the effects of surgical stimulus, intravenous anesthetics, vasodilators, anticholinergics, calcium channel blockers, beta-adrenergic agonists, and the presence of a nasogastric tube. 相似文献
992.
Michael J. Eckardt PhD Robert R. Rawlings MS Barry I. Graubard MA Vivian Faden PhD Peter R. Martin MD Louis A. Gottschalk MD PhD 《Alcoholism, clinical and experimental research》1988,12(1):88-93
Commonly used neuropsychological tests were administered to 91 detoxified alcoholics at the beginning of treatment. Statistically significant relationships were observed between test scores and post treatment consumption determined 8 months after completing treatment for 72 patients. The results varied depending upon the particular measure of posttreatment consumption evaluated and the type of statistical analysis used. The most consistent relationships were often counter to the notion that increased neuropsychological performance is correlated with a more favorable treatment outcome. Neuropsychological evaluation is of limited clinical utility in predicting posttreatment alcohol consumption. 相似文献
993.
994.
995.
996.
End-tidal Carbon Dioxide Monitoring during Procedural Sedation 总被引:2,自引:0,他引:2
James R. Miner MD William Heegaard MD MPH David Plummer MD 《Academic emergency medicine》2002,9(4):275-280
OBJECTIVE: To prospectively determine whether end-tidal carbon dioxide (ETCO2) monitors can detect respiratory depression (RD) and the level of sedation in emergency department (ED) patients undergoing procedural sedation (PS). METHODS: This was a prospective observational study conducted in an urban county hospital of adult patients undergoing PS. Patients were monitored for vital signs, depth of sedation per the physician by the Observer's Assessment of Alertness/Sedation scale (OAA/S), pulse oximetry, and nasal-sample ETCO2 during PS. Respiratory depression was defined as an oxygen saturation <90%, an ETCO2 >50 mm Hg, or an absent ETCO2 waveform at any time during the procedure. The physician also determined whether protective airway reflexes were lost during the procedure and assisted ventilation was required, or whether there were any other complications. Rates of RD were compared with the physician assessment of airway loss and between agents using chi-square statistics. Spearman's rho analysis was used to determine whether there was a correlation between ETCO2 and the OAA/S score. RESULTS: Seventy-four patients were enrolled in the study. Forty (54.1%) received methohexital, 21 (28.4%) received propofol, ten (13.5%) received fentanyl and midazolam, and three (4.1%) received etomidate. Respiratory depression was seen in 33 (44.6%) patients, including 47.5% of patients receiving methohexital, 19% receiving propofol (p = 0.008), 80% receiving fentanyl and midazolam, and 66.6% receiving etomidate. No correlation between OAA/S and ETCO2 was detected. Eleven (14.9%) patients required assisted ventilation at some point during the procedure, all of whom met the criteria for RD. Pulse oximetry detected 11 of the 33 patients with RD. Post-hoc analysis revealed that all patients with RD had an ETCO2 >50 mm Hg, an absent waveform, or an absolute change from baseline in ETCO2 >10 mm Hg. CONCLUSIONS: There was no correlation between ETCO2 and the OAA/S score. Using the criteria of an ETCO2 >50 mm Hg, an absolute change >10 mm Hg, or an absent waveform may detect subclinical RD not detected by pulse oximetry alone. The ETCO2 may add to the safety of PS by quickly detecting hypoventilation during PS in the ED. 相似文献
997.
BACKGROUND: Amalgam tattoos result from deposition of metallic particles (eg, silver, mercury, copper, zinc, and tin) into the oral mucosa. Their clinical and histologic appearance is similar to that of decorative tattoos. OBJECTIVE: To describe the successful use of a Q-switched alexandrite laser for removal of an amalgam tattoo. MATERIALS AND METHODS: An amalgam tattoo on the buccal mucosa and gingiva was treated with a QS 755 nm alexandrite laser. Three treatments were delivered at 8-week time intervals (average fluence = 6.8 J/cm2). RESULTS: Significant lightening of the tattoo was achieved after each of the three treatments without adverse sequelae. CONCLUSION: Q-switched alexandrite laser irradiation can safely and effectively eradicate amalgam tattoos. 相似文献
998.
EMMAPIRILÄMSc MATALEENAPARIKKADDS NUNGAVARM S. RAMAMURTHYPhD PÄIVIMAISIPhD STEVEMCCLAIN MD ALLANKUCINEDDS TAINATERVAHARTIALADDS KAIUPRIKKMD LORNE M. GOLUBDMD TUULASALOPhD & TIMOSORSAPhD 《Wound repair and regeneration》2002,10(1):38-51
Estrogen deficiency is associated with impaired cutaneous wound healing. Remodeling of the extracellular matrix in wound healing involves the action of matrix metalloproteinases on basement membrane zone components, especially laminin-5. We studied the effects of estrogen and a potent matrix metalloproteinase inhibitor, chemically modified non-antimicrobial tetracycline, CMT-8, on wound healing in ovariectomized rats. At the tissue level, laminin-5 gamma2-chain expression was decreased and the migration-inductive 80 kDa form of laminin-5 gamma2-chain was absent in ovariectomized rats when compared with sham and CMT-8- or estrogen-treated ovariectomized animals as detected by Western blotting. The highest levels of gelatinolytic activity (matrix metalloproteinase-2 and -9) were found in sham animals. Levels were reduced in ovariectomized rats and were lowest after treating ovariectomized rats with CMT-8 or estrogen as analyzed by functional activity assay and zymography. The total amount of membrane type 1-matrix metalloproteinase was unchanged in all groups. We conclude that CMT-8 and estrogen can promote wound healing in ovariectomized rats, not only by normalizing wound bed total collagen content and structure, but also by recovering the expression and processing of key molecules in wound healing, i.e., laminin-5 gamma2-chain. This study shows, for the first time, the role of estrogen and CMT-8 in laminin-5 gamma2-chain modulation in vivo. 相似文献
999.
1000.