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101.
Mechanical properties of dilated human ascending aorta 总被引:3,自引:0,他引:3
Okamoto RJ Wagenseil JE DeLong WR Peterson SJ Kouchoukos NT Sundt TM 《Annals of biomedical engineering》2002,30(5):624-635
Dilation of the ascending aorta, associated with Marfan Syndrome, bicuspid aortic valve, or advanced age, may lead to aortic dissection and rupture. Mathematical models can be used to assess the relative importance of increased wall stresses and decreased strength in these mechanical failures. To obtain needed inputs for such models, mechanical properties of dilated human ascending aorta were measured in vitro. Specimens for opening angle, biaxial elastic, and uniaxial circumferential strength tests were cut from excised tissue obtained from 54 patients (age 18–81 years) undergoing elective aortic graft replacement surgery. Opening angle was significantly greater in patients older than 50 years (262°±76°, n=21) compared to younger patients (202°±70°, n=13 All biaxial elastic specimens n=40 exhibited nonlinear stress-strain behavior. Rapid increases in circumferential and axial stresses occurred at lower strains in the older patient group than in the younger. Mean strength was significantly lower in older patients (1.35±0.37 MPa, n=14) than younger (2.04 ± 0.46 MPa, n=11, age <50 years). These changes in mechanical properties suggest that age may influence the risk of aortic dissection or rupture of dilated ascending aorta. © 2002 Biomedical Engineering Society.
PAC2002: 8719Rr, 8719Hh 相似文献
102.
Oral administration of muscle derived small molecules inhibits tumor spread while promoting normal cell growth in mice 总被引:5,自引:0,他引:5
Bar-Yehuda S Farbstein T Barer F Ohana G Fishman P 《Clinical & experimental metastasis》1999,17(6):531-535
Tumor metastases are extremely rare in striated muscles. This is surprising given the fact that this tissue constitutes 60%
of body weight. The present study focuses on small molecules produced and secreted by muscle cells which possess anti-cancer
activity in vivo. Recently we have shown that a low molecular weight fraction (<1000 Dalton) of skeletal muscle cell conditioned medium (muscle
factor-MF), markedly inhibits the proliferation of carcinoma, sarcoma or melanoma cell lines in vitro. The MF exerts a cytostatic effect on tumor cell growth and arrests the cells in the G0/G1 of the cell cycle. However, normal
cell proliferation, such as bone marrow and fibroblasts, was stimulated following incubation with MF. In this study, the effect
of orally administered MF on melanoma and sarcoma growth was examined in mice. The administration of MF to mice inoculated
intravenously with melanoma (B16–F10) or sarcoma (MCA-105) cells, resulted in a statistically significant inhibition of metastatic
lung foci. In a different model, melanoma was induced in the foot pad and after development of a local lesion, the leg was
amputated. A prolonged survival time was observed in the MF treated groups. Since the MF stimulated bone marrow cell proliferation
in vitro, we decided to test its efficacy as an inhibitor of the myelotoxic effect exerted by chemotherapy, in vivo. MF, administered after chemotherapy, restored the number of white blood cells and yielded an increased percentage of neutrophils
compared with the decline in these parameters after administration of chemotherapy alone. Thus, it is indicated that MF exerted
a systemic anti tumor and chemoprotective effect when given orally. It can be concluded that it is bioavailable and is not
biodegradable in the digestive system. MF may be considered as a potential therapy for the prevention of tumor spread.
This revised version was published online in July 2006 with corrections to the Cover Date. 相似文献
103.
Pastorino L Cusano R Bruno W Lantieri F Origone P Barile M Gliori S Shepherd GA Sturm RA Bianchi-Scarra G Scarra GB 《Human mutation》2004,24(1):103
Several variant forms of the melanocortin-1 receptor gene (MC1R) have been associated with red hair, fair skin and an increased risk for melanoma. Their involvement in melanoma susceptibility is apparently linked both to skin sensitivity and to non-pigmentary pathways. We investigated the frequency of the MC1R variants in the Italian region of Liguria, where the occurrence and penetrance of melanoma are low and primary susceptibility is characterized by prevalence of the CDKN2A c.301G>T [p.G101W] founder mutation. Additionally, we attempted to establish the frequency of the red hair/fair skin phenotype in our region. As predicted by anecdotal evidence, the frequency of red hair/phototype I was very low (0.7%). Screening of 17 red-haired individuals and their red-haired relatives, 207 controls and 214 melanoma patients unselected for hair color but all of Ligurian descent, led to the detection of 8 novel substitutions (c.133T>C [p.F45L], c.248C>T [p.S83L], c.332C>T [p. A111V], c.479G>A [p.R160Q], c.637C>T [p.R213W], c.793G>A [p. V265I], c.923C>T [p. T308M], c.943T>C [p.C315R]), 1 novel deletion (c.520_523delGTC [p.V174del]) and 3 novel synonymous variants (c.366G>C [p. V122V], c.684G>A [p. Q228Q], c.726C>T [p.T241T]). Preliminary genotype/phenotype correlation seems to indicate that other genes involved in the regulation of human pigmentation may mask the recessive action of high-penetrance MC1R alleles, thus determining the low frequency of at-risk phototypes and of incidence and/or penetrance of melanoma in Liguria. 相似文献
104.
Few studies have characterized or compared the pathologic features of bone marrow involvement by extranodal (EMZL), splenic (SMZL), and nodal marginal zone lymphoma (NMZL). We evaluated 45 bone marrow biopsy specimens from 39 patients with marginal zone lymphomas. As previously reported, bone marrow involvement was frequent (100%) in patients with SMZL. We also identified lymphoma involving bone marrow in 11 (44%) of 25 patients with EMZL and 1 of 2 patients with NMZL. The patterns of infiltration were mixed in all groups; however, the extent of involvement was greater in SMZL than in EMZL. In addition, germinal centers were present in bone marrow biopsy specimens involved by lymphoma in 4 patients with SMZL. Intrasinusoidal infiltration was common (10/12 [83%]) and prominent in patients with bone marrow involvement by SMZL, but was not invariably present. Intrasinusoidal infiltration of the bone marrow also was not specific for SMZL since similar infiltrates, although subtle, also were found in patients with other small B-cell lymphoproliferative disorders, including 6 (55%) of 11 patients whose bone marrow samples were infiltrated by EMZL. 相似文献
105.
Domenico Rosace Cristina Gomez-Casado Paloma Fernandez Marina Perez-Gordo María del Carmen Dominguez Angel Vega María Teresa Belver Tania Ramos Francisco Vega Guadalupe Marco Manuel de Pedro Leticia Sanchez María de las Mercedes Arnas Marcela Santaolalla Miguel Ángel Saez Sara Benedé Montserrat Fernandez-Rivas Carlos Blanco Domingo Barber 《The Journal of allergy and clinical immunology》2019,143(2):681-690.e1
106.
107.
Induced recruitment of NK cells to lymph nodes provides IFN-gamma for T(H)1 priming 总被引:13,自引:0,他引:13
Martín-Fontecha A Thomsen LL Brett S Gerard C Lipp M Lanzavecchia A Sallusto F 《Nature immunology》2004,5(12):1260-1265
Naive T cells are stimulated by antigen-presenting dendritic cells (DCs) in secondary lymphoid organs, but whether other types of cell participate in T cell priming is unclear. Here we show in mice that natural killer (NK) cells, which are normally excluded from lymph nodes, are rapidly recruited in a CCR7-independent, CXCR3-dependent manner to lymph nodes on stimulation by the injection of mature DCs. Recruitment of NK cells is also induced by some, but not all, adjuvants and correlates with the induction of T helper cell type 1 (T(H)1) responses. NK cell depletion and reconstitution experiments show that NK cells provide an early source of interferon-gamma (IFN-gamma) that is necessary for T(H)1 polarization. Taken together, our results identify an induced pathway of NK cell migration in antigen-stimulated lymph nodes and a mechanism by which some adjuvants may facilitate T(H)1 responses. 相似文献
108.
109.
The restorative effect of naps on perceptual deterioration 总被引:4,自引:0,他引:4
Mednick SC Nakayama K Cantero JL Atienza M Levin AA Pathak N Stickgold R 《Nature neuroscience》2002,5(7):677-681
Human performance on visual texture discrimination tasks improves slowly (over days) in the absence of additional training. This 'slow learning' requires nocturnal sleep after training and is limited to the region of visual space in which training occurred. Here, we tested human subjects four times in one day and found that with repeated, within-day testing, perceptual thresholds actually increased progressively across the four test sessions. This performance deterioration was prevented either by shifting the target stimuli to an untrained region of visual space or by having the subjects take a mid-day nap between the second and third sessions. 相似文献
110.
Gamma-Interferon is Produced by CD3+ and CD3- Lymphocytes 总被引:7,自引:0,他引:7
Sara Sandvig Tamas Laskay Jan Andersson Marc De Ley Ulf Andersson 《Immunological reviews》1987,97(1):51-65