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排序方式: 共有266条查询结果,搜索用时 203 毫秒
31.
George N. Okoli Morgan Stirling Florentin Racovitan Otto LT Lam Viraj K. Reddy Leslie Copstein Tina Hsu Ahmed M. Abou-Setta David E. Dawe 《Current problems in cancer》2021,45(3):100699
Sixty percent of newly diagnosed cancers occur in older adults and more complex planning is required to sustain quality care for older populations. Individualized care incorporating geriatric assessment can predict early mortality and treatment toxicity for older cancer patients. We mapped and summarized the available evidence on the integration of geriatric assessment into clinical oncology practice, and ascertained which domains have been implemented. We systematically searched bibliographic databases and trial registries for reports of clinical studies, clinical practice guidelines, systematic and non-systematic reviews, and grey literature published in English. We gathered data on study characteristics, geriatric domains and strategies evaluated, and relevant study objectives and findings. From a total of 10,124 identified citations, 38 articles met our eligibility criteria, 3 of which were clinical practice guidelines. Nearly half of these articles came from the United States. Domains of the geriatric assessment implemented in studies ranged from 1 to 12, with varied combinations. We identified 27 studies on strategies for implementing geriatric assessment and 24 studies on feasibility of implementing geriatric assessment, into clinical oncology practice. We also identified 3 main geriatric assessment models: 2 from the United States and 1 from Australia. Furthermore, we identified 2 reviews that reported varied components of geriatric assessment models. There is increasingly robust evidence to implement formal geriatric assessment in oncology practice. There remains a great deal of variation in the tools recommended to address each of the domains in a geriatric assessment, with only 1 guideline (American Society of Clinical Oncology guideline) settling on a specific best practice.Protocol registration: Open Science Framework osf.io/mec93. 相似文献
32.
S. Krid LT. Roumenina D. Beury M. Charbit O. Boyer V. Frémeaux‐Bacchi P. Niaudet 《American journal of transplantation》2012,12(7):1938-1944
We report the first observation of successful kidney transplantation under pre‐emptive eculizumab treatment in a 7‐year‐old boy with atypical hemolytic uremic syndrome (aHUS) and a known hybrid CFH/CFHR1 gene, who was dependent on plasma therapy during the 3‐year dialysis period. The hybrid CFH/CFHR1 protein has an altered C3b/C3d binding, is incapable to protect cells from complement attack and is directly implicated in aHUS pathogenesis. There was no evidence of recurrence during the first 16‐month follow‐up period. We conclude that eculizumab alone, without plasma therapy (plasma infusion and/or plasma exchange), is sufficient to prevent recurrence of aHUS and to maintain long‐term graft function. 相似文献
33.
LT. M.C. Edwin L. Rothfeld USNR LT. M.C. Richard M. Zirkin USNR 《The American journal of cardiology》1962,10(6):882-885
A case of metastatic carcinoma of the left atrium is described. The correct antemortem diagnosis was made on the basis of electrocardiographic changes resembling atrial infarction. These included deformed P waves, deviation of the P-Ta segments and atrial arrhythmias. 相似文献
34.
Corpus callosum and limbic system: neuroanatomic MR evaluation of developmental anomalies 总被引:4,自引:0,他引:4
Atlas SW; Zimmerman RA; Bilaniuk LT; Rorke L; Hackney DB; Goldberg HI; Grossman RI 《Radiology》1986,160(2):355-362
Agenesis of the corpus callosum is a complex malformation of the brain that has been associated with varying degrees of limbic system maldevelopment. We retrospectively reviewed the records of 11 patients with callosal agenesis (seven total, four partial) who underwent magnetic resonance (MR) imaging, with particular attention to the associated malformations of the limbic system. Comparison was made with selected images from MR examinations of healthy volunteers and with necropsy specimens from other patients with callosal agenesis. Ten of 11 patients demonstrated limbic anomalies (severe motion artifact precluded evaluation of these structures in one patient). MR depicted not only the abnormalities intrinsic to callosal agenesis but also the frequently associated malformations of the limbic system. 相似文献
35.
The resection of the columella and nasal depressor muscles is a simple operation to perform and one which allows an improvement in the facial physiognomy of many patients. This operation can be done alone or in conjunction with the classic rhinoplasty, thus achieving an improvement in the aesthetics of the smile. It has also been proved, contrary to common belief, that the action of these muscles has no connection with physiological breathing mechanisms. 相似文献
36.
Effect of parental age on fertilization and pregnancy characteristics in couples treated by intracytoplasmic sperm injection 总被引:11,自引:5,他引:6
Spandorfer SD; Avrech OM; Colombero LT; Palermo GD; Rosenwaks Z 《Human reproduction (Oxford, England)》1998,13(2):334-338
The purpose of this study was to investigate any influence of maternal
and/or paternal age on gamete characteristics and pregnancy outcomes in
intracytoplasmic sperm injection (ICSI) cycles. In all, 821 consecutive
ICSI cases were analysed retrospectively. While a significant linear
decline in semen volume was detected, no significant differences in the
concentration, motility or morphology of the spermatozoa were found with
paternal ageing. A significant decline in the number of oocytes retrieved
and the number of mature oocytes obtained was found with advancing maternal
age. An increase in the occurrence of digyny was noted with parental
ageing, while no difference in single or bipronuclear fertilization was
found. Older women had a decreased incidence of single pronucleus formation
and an increase in digyny, but no significant difference in the percentage
of oocytes that underwent two-pronuclear fertilization was detected with
regard to maternal ageing. Pregnancy outcomes were not influenced by the
age of the male partner, while a strong negative correlation was found with
maternal ageing. To better analyse male partner ageing as a factor
affecting pregnancy outcome, we analysed a subgroup of patients with a
female partner aged <35 years who underwent ICSI. No paternal influence
on ICSI pregnancy outcome was found in this subgroup of patients. We
conclude that the influence on pregnancy outcome after ICSI is related
mostly to maternal and not paternal age.
相似文献
37.
38.
Computed tomography of acute intratumoral hemorrhage 总被引:13,自引:0,他引:13
39.
40.
B. H. Sullivan Jr. COL. MC U. S. ARMY Nelson S. Irey LT. COL. MC U. S. ARMY Vincent J. Pileggi ST LT. MSC U. S. ARMY Richard I. Crone COL. MC U. S. ARMY John R. Gibson LT. COL. MC U. S. ARMY 《Digestive diseases and sciences》1957,2(4):210-223
Summary 1. Twenty-two patients with infectious mononucleosis were studied by liver biopsy and paper electrophoresis of the serum proteins. The findings were compared with a similar group of 30 patients with infectious hepatitis.2. The essential histologic features of infectious mononucleosis were the presence in the hepatic sinusoids and portal tracts of chronic inflammatory cells resembling small lymphocytes, with essentially no parenchymal cell damage. Admixed with this lymphocytic infiltrate, but in relatively minimal numbers, were a few plasma cells and polymorphonuclear leukocytes. In addition, in infectious mononucleosis there were, with rare exceptions, no lipochrome-containing Kupffer cells. Thus, in the majority of cases, the histologic picture was distinct from that seen in infectious hepatitis. Only in comparing a few of the more severe infectious mononucleosis cases with subsiding infectious hepatitis cases was there any tendency for the two pictures to merge, and the distinction on histologic grounds between the two entities could be made in the great majority of cases.3. The most commonly seen abnormalities in the paper electrophoretic patterns of sera obtained from patients with infectious mononucleosis were decreased albumin, increased gamma globulin, not infrequent but variable changes in alpha2 globulin, and the presence of abnormal proteins migrating with mobilities intermediate to alpha2 and beta, and beta and gamma globulins. The abnormalities observed in infectious hepatitis were similar to those of infectious mononucleosis, except that in hepatitis alpha2 globulin was decreased more consistently, gamma globulin increased less frequently, and beta globulin, which was normal in practically all the cases of infectious mononucleosis, was increased in a considerable number of cases.4. Treatment of patients with infectious mononucleosis need not include prolonged bed rest and restriction of activity in an effort to avoid the development of chronic liver disease. 相似文献