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101.
102.
We report the unusual association of facial palsy and severe hypertension in an infant with coarctation of the aorta. The facial palsy resolved before the hypertension was cured. 相似文献
103.
Sandle T 《PDA journal of pharmaceutical science and technology / PDA》2004,58(4):231-237
Many statistical textbooks lend themselves readily to the analysis of physical and chemical data. This is due to the material gathered from such analyses, following, in most cases, normal distribution. Normally distributed data can be examined over time to allow the obtained profile to be studied for variation. Microbiological data rarely follows such distribution. However, such approaches can be adapted for non-normally distributed (or skewed) microbiological data. This paper applies Shewhart Control Charts to the trend analysis of microbiological data from two different pharmaceutical water systems. 相似文献
104.
Objective : To describe the presentation and investigation of an unusual form of congenital dorsal midline thoracic mass.
Results : An infant born by emergency Caesarean section at 34 weeks gestation was found to have a large dorsal midline thoracic mass. The infant had normal neurological function in all limbs. Radiological investigation showed no abnormality in the vertebrae. Ultrasonographic investigation suggested the mass to consist of subcutaneous oedema. The mass resolved completely within the first 2 weeks.
Conclusions : The lesion observed in this infant represents a very unusual location for a benign condition caused by cervical pressure on the presenting fetal part. The use of ultrasonography enabled rapid exclusion of the more common, potentially serious, causes of a congenital midline dorsal thoracic mass. 相似文献
Results : An infant born by emergency Caesarean section at 34 weeks gestation was found to have a large dorsal midline thoracic mass. The infant had normal neurological function in all limbs. Radiological investigation showed no abnormality in the vertebrae. Ultrasonographic investigation suggested the mass to consist of subcutaneous oedema. The mass resolved completely within the first 2 weeks.
Conclusions : The lesion observed in this infant represents a very unusual location for a benign condition caused by cervical pressure on the presenting fetal part. The use of ultrasonography enabled rapid exclusion of the more common, potentially serious, causes of a congenital midline dorsal thoracic mass. 相似文献
105.
Thiriloganathan Mathialahan Geoffrey I Sandle 《Nephrology, dialysis, transplantation》2003,18(2):341-347
BACKGROUND: In end-stage renal disease (ESRD), colonic potassium (K+) secretion increases as renal K+ excretion declines. The nature of this adaptive process is poorly understood, but post-prandial increases in plasma K+ concentration may be a determining factor. In addition, even though colonic K+ secretion increases in ESRD, interdialytic hyperkalaemia is a serious problem in haemodialysis patients, which might be reduced by stimulating colonic K+ secretion still further using laxatives. METHODS: Plasma K+ concentrations were measured in the fasting state, and for 180 min after the oral administration of 30 mmol of K+ to nine control subjects and 16 normokalaemic patients with ESRD (eight "predialysis" patients and eight patients undergoing continuous ambulatory peritoneal dialysis (CAPD)). Plasma K+ concentrations were also monitored for 180 min in fasting controls and ESRD patients who were not given the oral K+ load. To study the effect of laxatives on interdialytic hyperkalaemia, plasma K+ concentrations were measured in eight control subjects and 13 haemodialysis patients before and during 2 weeks treatment with bisacodyl (a cAMP-mediated laxative) and in five haemodialysis patients before and during 2 weeks treatment with lactulose (an osmotic laxative). RESULTS: Oral K+ loading caused plasma K+ concentration to rise within the normal range (3.5-5.1 mmol/l) in control subjects, while significantly higher concentrations were achieved in the "predialysis" patients and sustained hyperkalaemia developed in the CAPD patients. Bisacodyl treatment had no effect on plasma K+ concentrations in control subjects, but significantly decreased the mean interdialytic plasma K+ concentration (from 5.9+/-0.2 to 5.5+/-0.2 mmol/l, P<0.0005) in haemodialysis patients, whereas plasma K+ concentration did not change during lactulose treatment. CONCLUSIONS: Higher plasma K+ concentrations after food may help to maintain K+ homeostasis in ESRD by enhancing colonic K+ secretion. Bisacodyl may be useful for reducing interdialytic hyperkalaemia in patients undergoing haemodialysis. 相似文献
106.
Whitehouse PA Mercer SJ Knight LA Di Nicolantonio F O'Callaghan A Cree IA;Portsmouth Upper GI Colorectal Cancer Multidisciplinary Teams 《British journal of cancer》2003,89(12):2299-2304
Advanced or metastatic disease is common in both oesophagogastric and colorectal cancers, with poor 5-year survival despite palliative chemotherapy. We have investigated the sensitivity of gastrointestinal tumours to gemcitabine in combination with mitomycin C (GeM), using a modified ex vivo ATP-based tumour chemosensitivity assay (ATP-TCA). Tumour material from 41 colorectal and 22 oesophagogastric cancers were assessed. The GeM combination showed variable but definite activity in most of the samples tested. The results show that GeM achieves >95% inhibition at concentrations within the range achievable clinically in 60% of colorectal tumours (21 out of 35) and 38% of oesophagogastric tumours (five out of 13) tested. We did not identify any significant difference in sensitivity using concurrent or sequential exposure of tumour-derived cells to these two drugs. The results from this study suggest that GeM may be a useful combination in the treatment of advanced gastrointestinal malignancy. 相似文献
107.
We review evidence suggesting that the brain of maternally behaving rats is altered as a result of the behavior of the animal towards her pups. Morphological changes seen in the supraoptic nucleus, which contains oxytocinergic neurons important for lactation, are observed not only in parturient, lactating animals but also in virgin animals induced by the presence of rat pups to behave maternally. The supraoptic nuclei of lactating and maternally behaving virgin animals have a higher incidence of dendritic bundling relative to non-maternal virgin animals. Also, stimulation of the lateral olfactory tract in in vitro brain slices elevates electrotonic coupling among supraoptic neurons only in maternally behaving animals and not in male or non-maternal virgins. In general the evidence presented supports the idea that maternal behavior in lactating and non-lactating animals, can have profound effects on the morphology and physiological functioning of oxytocinergic neurons in the hypothalamus. 相似文献
108.
Variants of Brugada Syndrome and Early Repolarization Syndrome: An Expanded Concept of J‐Wave Syndrome 下载免费PDF全文
SUNG‐HWAN KIM M.D. GI‐BYOUNG NAM M.D. SUNG‐CHEOL YUN Ph.D. HYUNG OH CHOI M.D. KEE‐JOON CHOI M.D. BOYOUNG JOUNG M.D. HUI‐NAM PAK M.D. MOON‐HYOUNG LEE M.D. SUNG SOON KIM M.D. SEUNG‐JUNG PARK M.D. YOUNG KEUN ON M.D. JUNE SOO KIM M.D. IL‐YOUNG OH M.D. EUE‐KEUN CHOI M.D. SEIL OH M.D. F.H.R.S. YUN‐SHIK CHOI M.D. JONG IL CHOI M.D. SANG WEON PARK M.D. YOUNG‐HOON KIM M.D. YONG‐SEOG OH M.D. MAN YOUNG LEE M.D. HONG EUY LIM M.D. YOUNG‐SOO LEE M.D. YONGKEUN CHO M.D. JUN KIM M.D. KYOUNG‐SUK RHEE M.D. DONG‐IL LEE M.D. DAE KYOUNG CHO M.D. YOU‐HO KIM M.D. 《Pacing and clinical electrophysiology : PACE》2017,40(2):162-174
109.
110.
Enhanced rectal potassium secretion in chronic renal insufficiency: evidence for large intestinal potassium adaptation in man 总被引:4,自引:0,他引:4
G I Sandle E Gaiger S Tapster T H Goodship 《Clinical science (London, England : 1979)》1986,71(4):393-401
The role of the large intestine in K+ excretion in chronic renal insufficiency was studied with a rectal dialysis technique in 14 normal subjects and eight normokalaemic, normotensive patients with chronic renal insufficiency. At initial intraluminal K+ concentrations of 10, 20, 30 and 45 mmol/l, net K+ secretion in patients with renal insufficiency was significantly greater than in normal subjects by approximately 1.8 mumol h-1 cm-2. The increase in net K+ secretion was more marked in those patients with creatinine clearances of less than 10 ml/min. In contrast, there were no significant differences in net Na+ and water transport, transmucosal potential difference and plasma aldosterone concentrations between the two groups. With an initial intraluminal K+ concentration of 30 mmol/l, the addition of amiloride (final concentration 1 mmol/l) to the rectal lumen decreased net Na+ absorption and transmucosal potential difference in normal subjects by 69% (P less than 0.005) and 31% (P less than 0.005) respectively, and in patients with renal insufficiency by 75% (P less than 0.05) and 36% (P less than 0.05) respectively, but there was no change in net K+ secretion in either group. These results indicate that the K+ secretory capacity of the rectal mucosa increases in chronic renal insufficiency, and the large intestine may therefore contribute to the maintenance of K+ homoeostasis as renal K+ excretion declines. Increased rectal K+ secretion in renal insufficiency occurs independently of changes in plasma K+ and aldosterone concentrations, net Na+ absorption and transmucosal potential difference, and may reflect stimulation of an active K+ secretory process. 相似文献