全文获取类型
收费全文 | 106篇 |
免费 | 15篇 |
国内免费 | 1篇 |
专业分类
儿科学 | 3篇 |
基础医学 | 14篇 |
口腔科学 | 4篇 |
临床医学 | 8篇 |
内科学 | 36篇 |
皮肤病学 | 1篇 |
神经病学 | 8篇 |
特种医学 | 2篇 |
外科学 | 12篇 |
综合类 | 2篇 |
预防医学 | 8篇 |
眼科学 | 1篇 |
药学 | 9篇 |
肿瘤学 | 14篇 |
出版年
2024年 | 1篇 |
2023年 | 3篇 |
2022年 | 6篇 |
2021年 | 15篇 |
2020年 | 10篇 |
2019年 | 11篇 |
2018年 | 11篇 |
2017年 | 8篇 |
2016年 | 6篇 |
2015年 | 8篇 |
2014年 | 10篇 |
2013年 | 4篇 |
2012年 | 6篇 |
2011年 | 9篇 |
2010年 | 2篇 |
2009年 | 2篇 |
2008年 | 4篇 |
2007年 | 3篇 |
2006年 | 1篇 |
2005年 | 1篇 |
2002年 | 1篇 |
排序方式: 共有122条查询结果,搜索用时 406 毫秒
71.
72.
Introduction
The present study was conducted as a pilot to compare the therapeutic effects and the potential side effects of oral Megestrol acetate and Letrozole in the treatment of simple hyperplasia in perimenopausal women.Methods
The participants of this randomized clinical trial consisted of two groups of 25 women aged 44–50 presenting with abnormal uterine bleeding diagnosed with simple endometrial hyperplasia without cytologic atypia confirmed by transvaginal ultrasonography and biopsy. The first group received 40-mg doses of Megestrol acetate for 2 weeks per month for a total period of 2 months. The second group received 2.5-mg daily doses of Letrozole for a total period of 2 months. The differences in terms of quantitative measurements were analyzed using the independent two-sample t test and the paired t test. To compare the two groups in terms of the distribution of the categorical variables, Pearson’s Chi square and Fisher’s Exact tests were used at the significance level of 0.05 by Stata-9.2.Results
Although the intervention led to significant improvements in both groups (P < .001), there was no difference between the groups in terms of accomplishing resolution (P = .74) [seven (28%) patients in the Letrozole group and five (20%) in the Megestrol group], while two patients in the Letrozole group and nine in the Megestrol group suffered from side effects, suggesting significantly lower side effects in the Letrozole group (P = .02).Conclusion
Letrozole and Megestrol acetate seem to have similar effects on the treatment of simple endometrial hyperplasia, the only difference being that Letrozole presents fewer side effects than Megestrol acetate in patients with this condition.Funding
Abnormal Uterine Bleeding Research Center of Semnan University of Medical Sciences, Semnan, Iran. Trial Registration: IRCT2015031011504N573.
74.
Amir Afkham Leili Aghebati-Maleki Homayoon Siahmansouri Sanam Sadreddini Majid Ahmadi Sanam Dolati Nahid Manafi Afkham Parvin Akbarzadeh Farhad Jadidi-Niaragh Vahid Younesi Mehdi Yousefi 《Pharmacological reports : PR》2018,70(3):418-425
Background
Prostate cancer is known as the most common malignancy in men. Chitosan has generated great interest as a useful biopolymer for the encapsulation of small interfering RNA (siRNA). Due to cationic nature, chitosan is able to efficiently encapsulate siRNA molecules and form nanoparticles. Furthermore, the biocompatible and biodegradable attributes of chitosan have paved the way for its potential application in the in vivo delivery of therapeutic siRNAs. In this study, we aimed to design chitosan/CMD nanoparticles for the efficient encapsulation of the anti-cancer drugs SN38 and Snail-specific siRNA.Methods
Physicochemical characteristics, growth inhibitory properties, and anti-migratory capacities of the dual delivery of SN38-Snail siRNA CMD-chitosan nanoparticles were investigated in prostate cancer cells.Results
Our findings provided evidence for the suggestion that, ChNP-CMD-SN38-siRNA treated cells, the mRNA level of snail decreased from 1.00 to 0.30 (±0.14) and 0.09 (±0.04) after 24 h and 48 h, respectively. Additionally, the fold induction of E-cadherin and Claudin-1 increased from 1.00 to now 3.12 (±0.62), 3.02 (±0.28) after 24 h and 5.6 (±0.91), 4.42 (±0.51) after 48 h, respectively. Also, co-delivery of SN38 and Snail-specific siRNA by an appropriate nanocerrier (chitosan nanoparticles) could reduce the viability, proliferation, and migration of PC-3 cells.Conclusions
In conclusion, ChNPs encapsulating SN38 and Snail-specific siRNA may represent huge potential as an effective anti-cancer drug delivery system for the treatment of prostate cancer. 相似文献75.
Mahran Shoukier MD Tapan Kadia MD Marina Konopleva MD PhD Ahmad S. Alotaibi MD Mansour Alfayez MD Sanam Loghavi MD Keyur P. Patel MD PhD Rashmi Kanagal-Shamanna MD Jorge Cortes MD Bachar Samra MD Elias Jabbour MD Guillermo Garcia-Manero MD Koichi Takahashi MD PhD Sherry Pierce RN BS BA Nicholas J. Short MD Musa Yilmaz MD Koji Sasaki MD PhD Lucia Masarova MD Naveen Pemmaraju MD Gautam Borthakur MD Hagop M. Kantarjian MD Farhad Ravandi MD Courtney D. DiNardo MD Naval Daver MD 《Cancer》2021,127(3):381-390
76.
Prediction of survival with lower intensity therapy among older patients with acute myeloid leukemia
Koji Sasaki MD Farhad Ravandi MD Tapan M. Kadia MD Gautam Borthakur MD Nicholas J. Short MD Nitin Jain MD Naval G. Daver MD Elias J. Jabbour MD Guillermo Garcia-Manero MD Sanam Loghavi MD Keyur P. Patel MD Guillermo Montalban-Bravo MD Lucia Masarova MD Courtney D. DiNardo MD Hagop M. Kantarjian MD 《Cancer》2023,129(7):1017-1029
77.
Hamed Ahmadi Seyedeh Sanam Ladi-Seyedian Badrinath Konety Kamal Pohar Jeffrey M. Holzbeierlein Max Kates Brian Willard Jennifer M. Taylor Joseph C. Liao Hristos Z. Kaimakliotis Sima P. Porten Gary D. Steinberg Mark D. Tyson Yair Lotan Siamak Daneshmand the Blue Light Cystoscopy with Cysview Registry Group 《BJU international》2022,130(1):62-67
78.
Mona Ghazanfari Mehraban Falahati Azam Fattahi Fatemeh Bazrafshan Sanam Nami Morteza Hosseinzadeh Fariba Heydarikohan Mohsen Ghelman Majid Khoshmirsafa Ali Farzanegan 《Mycoses》2019,62(2):106-111
Recurrent vulvovaginal candidiasis (RVVC) is a common opportunistic, mucosal fungal infection, predominantly caused by the fungus Candida albicans. Mannose‐binding lectin (MBL) is an acute‐phase protein that plays a key role in the innate immunity defence against infectious disease. This study was conducted to evaluate the relationship between the MBL serum level and the relative expression of MBL mRNA in RVVC using real‐time PCR for the first time. The case‐control study included 40 female participants suffering from RVVC and 40 healthy individuals. The MBL serum level was measured using a commercial ELISA kit. The relative mRNA expression of the MBL gene was quantified using real‐time PCR. Data analysis was carried out by spss software. The MBL concentration was significantly higher in the participants suffering from RVVC compared to the control group (0.330 ng/mL vs 0.253 ng/mL). The prognostic value (P < .001) for RVVC diagnosis has been calculated. Quantitative RT‐PCR results from 35 samples showed a low to significant values for mRNA levels corresponding to MBL gene expression (1‐352 folds) (P < .001). The results of this study suggest that MBL plays a main role in the innate immunity and it is also affected by environmental factors and other genetic variations. Therefore, the MBL gene expression profile does not reflect precise phenotypic levels in the serum. 相似文献
79.
80.
Julia M. Alber Chari Cohen Giang T. Nguyen Sanam F. Ghazvini Brenda Trang Tolentino 《Journal of health communication》2013,18(12):977-983
In the United States, Asian Americans account for 50–60% of hepatitis B virus infections, leading to higher rates of liver cancer in this population. While some city-wide data have reported hepatitis B infection rates among young adults as high as 10–20%, little research has examined factors that impact hepatitis B beliefs, or the most effective strategies for reaching this particular population to promote hepatitis B awareness. An online survey was conducted with young Asian American adults (n = 418), aged 18–29 years old, to better understand their health information seeking, social media usage, and hepatitis B-related behaviors and beliefs. Results indicated that doctors and health organizations were the most trusted sources of health information, while the Internet was the most common source of health information. The majority of participants (99.8%) reported using social media and indicated they engaged in health-related behaviors on social media. Several factors, including non-receipt of hepatitis B vaccine, engaging in more health-related social media activities, and a higher mean score for difficulty with health information seeking, were significantly related to higher perceived susceptibility to hepatitis B. Future research should explore the effectiveness of using social media to reach young Asian American adults to promote hepatitis B awareness. 相似文献