全文获取类型
收费全文 | 10475篇 |
免费 | 2656篇 |
国内免费 | 56篇 |
专业分类
耳鼻咽喉 | 155篇 |
儿科学 | 310篇 |
妇产科学 | 276篇 |
基础医学 | 350篇 |
口腔科学 | 346篇 |
临床医学 | 3477篇 |
内科学 | 1963篇 |
皮肤病学 | 242篇 |
神经病学 | 1117篇 |
特种医学 | 271篇 |
外科学 | 1949篇 |
综合类 | 59篇 |
一般理论 | 1篇 |
预防医学 | 1320篇 |
眼科学 | 499篇 |
药学 | 167篇 |
中国医学 | 8篇 |
肿瘤学 | 677篇 |
出版年
2024年 | 88篇 |
2023年 | 501篇 |
2022年 | 153篇 |
2021年 | 321篇 |
2020年 | 433篇 |
2019年 | 237篇 |
2018年 | 742篇 |
2017年 | 791篇 |
2016年 | 710篇 |
2015年 | 744篇 |
2014年 | 901篇 |
2013年 | 949篇 |
2012年 | 452篇 |
2011年 | 464篇 |
2010年 | 625篇 |
2009年 | 744篇 |
2008年 | 367篇 |
2007年 | 275篇 |
2006年 | 289篇 |
2005年 | 242篇 |
2004年 | 177篇 |
2003年 | 126篇 |
2002年 | 132篇 |
2001年 | 199篇 |
2000年 | 87篇 |
1999年 | 179篇 |
1998年 | 258篇 |
1997年 | 243篇 |
1996年 | 307篇 |
1995年 | 213篇 |
1994年 | 215篇 |
1993年 | 164篇 |
1992年 | 130篇 |
1991年 | 112篇 |
1990年 | 66篇 |
1989年 | 78篇 |
1988年 | 65篇 |
1987年 | 64篇 |
1986年 | 59篇 |
1985年 | 40篇 |
1984年 | 40篇 |
1983年 | 27篇 |
1982年 | 33篇 |
1981年 | 17篇 |
1980年 | 19篇 |
1979年 | 14篇 |
1978年 | 13篇 |
1977年 | 10篇 |
1975年 | 8篇 |
1971年 | 11篇 |
排序方式: 共有10000条查询结果,搜索用时 0 毫秒
11.
Allison J. Cowin PhD ; Nicholas Hatzirodos BSc ; Justin Rigden PhD ; Robert Fitridge FRACS ; David A. Belford PhD 《Wound repair and regeneration》2006,14(4):421-426
High levels of tumor necrosis factor-alpha (TNF-alpha), a pro-inflammatory cytokine, are present in the wound fluid of chronic nonhealing wounds. This leads to increased inflammation, cytokine expression, and ultimately results in impaired wound healing and tissue destruction. Etanercept is a recombinant fusion protein that consists of the soluble TNF receptor (p75) linked to the Fc portion of human IgG1. It is an effective inhibitor of TNF-alpha and has been shown to provide rapid and sustained improvement in rheumatoid arthritis by acting as a soluble receptor binding TNF-alpha and preventing its proinflammatory activities. Therefore, the aim of this study was to determine whether Etanercept could inhibit TNF-alpha activity in chronic wound fluid. Wound fluid was collected from the venous leg ulcers of 16 different patients. The effect of Etanercept on TNF-alpha activity was evaluated using both a TNF-alpha bioassay and an enzyme-linked immunoassay. Etanercept was found to reduce the cytotoxic effect of chronic wound fluid on L929 fibroblasts by approximately 30% and neutralized TNF-alpha binding in the enzyme-linked immunoassay by up to 80%. Direct application of Etanercept to chronic wounds may therefore reduce the inflammatory activity of TNF-alpha, which could reduce the chronicity of venous leg ulcers and thus aid in the healing of these wounds. 相似文献
12.
Peter Stone MD FRNZCOG FRCOG David Cook FRNZCOG MRCOG John Hutton PhD FRNZCOG FRCOG Gordon Purdie BSc Henry Murray MD FRNZCOG MRCOG Lauren Harcourt MPP BA 《The Australian & New Zealand journal of obstetrics & gynaecology》1995,35(1):32-37
Summary: This is the first report of the largest study of blood pressure measurement in pregnancy in a New Zealand population using standardized definitions and methodology. Over 3,800 women who delivered in an 8-month period in the Wellington region were included in the study. Blood pressure measurement and the presence of oedema and proteinuria were recorded from booking until delivery and in the puerperium. Only 2.7% of women were unable to be contacted after delivery for details on outcomes. The results established normal ranges for blood pressure throughout pregnancy. The data show that Mood pressure greater than 140/90 until 35 weeks' gestation is outside 2 standard deviations at all gestations and justifies using these measurements as the definition of hypertension in pregnancy. The fall in blood pressure in the 2nd trimester was less than 1 mm Ffg per week in both the systolic and diastolic pressures. This fall was smaller than previously recorded in other studies. Gestational hypertension was the commonest blood pressure abnormality occurring in 15.2% of the population. This represented 69% of the pregnant women with a hypertensive disorder. The overall incidence of both gestational hypertension and preeclampsia was 18.5% which is higher than reported in other parts of the world. In this study obesity was significantly associated with hypertensive disorders in pregnancy. An arm circumference of >33 cm, one of the measurements of obesity, was found in 6.8% of the study population. Even after the effect of arm circumference was taken into account, hypertensive disorders were also more common in Pacific Island women. Ankle oedema was significantly associated with the development of both gestational hypertension and preeclampsia but the incidence of oedema was noted in only 11.9% of the subjects. 相似文献
13.
14.
15.
Osteochondral Fracture of the Fourth Metatarsal Head Treated by Open Reduction and Internal Fixation
Praveen K.R. Mereddy MBBS MSOrth DNB Orth MRCSEd Andrew Molloy MBchB MRCS FRCS Michael S. Hennessy BSc MBchB FRCSEd 《The Journal of foot and ankle surgery》2007,46(4):320-322
Fracture of the metatarsal head is uncommon, and reports of isolated osteochondral fracture of the metatarsal head are rare. Because of the distal location of the fracture, it is difficult to achieve and maintain reduction, and potential complications include avascular necrosis and subchondral fatigue fracture. The authors present a case of an osteochondral fracture in a 40-year-old man, which was treated by open reduction and internal fixation with a single twist-off screw, with good results 12 months postoperatively. 相似文献
16.
Qualitative Data Analysis: An Introduction 总被引:1,自引:1,他引:0
17.
Transabdominal sacrocolpopexy has been shown, in multiple long-term studies of its success and durability, to be the definitive
treatment option for post-hysterectomy vaginal vault prolapse. It is, however, associated with greater morbidity than vaginal
repair. We describe a minimally invasive technique for vaginal vault prolapse repair and present our experience with a minimum
of one-year follow-up. The surgical technique involves five laparoscopic ports—three for the da Vinci robot and two for the
assistant. After appropriate dissection a polypropylene mesh is attached to the sacral promontory and to the vaginal apex
by use of Gore-Tex sutures. The mesh material is then covered by the peritoneum. Patient analysis focused on complications,
urinary continence, patient satisfaction, and morbidity, with a minimum of 12 months follow-up. Forty-two patients with post-hysterectomy
vaginal vault prolapse underwent robot-assisted laparoscopic sacrocolpopexy at our institute and 35 have a minimum of 12 months
follow-up, with a mean follow-up of 36 months (range 12–48) in the group. Mean age was 67 (47–83) years and mean operating
time was 3.1 (2.15–4.75) h for the entire cohort. All but one patient were discharged home on postoperative day one; one patient
left on postoperative day two. One developed recurrent grade three rectocele, one had recurrent vault prolapse, and two suffered
from vaginal extrusion of mesh. All patients were satisfied with their outcome. The robot-assisted laparoscopic sacrocolpopexy
is a minimally invasive technique for vaginal vault prolapse repair, combining the advantages of open sacrocolpopexy with
the reduced morbidity of laparoscopy. We observed reduced hospital stay, low occurrence of complications, and high patient
satisfaction, with a minimum of 1-year follow-up. Most importantly, the long-term results of the robotic repair are similar
to those of open repair, but with significantly less morbidity. 相似文献
18.
Ruth McDonald BA MSc PhD Stephen Harrison BSc MPhil PhD 《Health & social care in the community》2004,12(3):194-201
Recent New Labour policy for the ‘modernisation’ of Government places a good deal of emphasis on decentralisation. This emphasis is particularly marked in relation to the organisation of primary care. However, like hospitals and other National Health Service institutions, primary care trusts (PCTs) are subject to a substantial raft of centrally established performance targets and indicators, including those which contribute to the public award of between zero and three performance ‘stars’. This raises questions about the extent to which employees can exercise autonomy in the context of rigid top‐down directives. This paper presents findings from a study using participant observation and interviews to examine the impact of a training course aimed ostensibly at increasing employee autonomy in an English PCT. The suggestion is that attempts to make employees more autonomous can be seen as a strategy for increasing central control based upon the internalisation by the employees of centrally promulgated values. The attraction of such strategies is that they may be potentially more effective and less costly than alternative strategies of direct control. However, the study suggests that the outcome of attempts by such methods as programmes to increase employee autonomy may be very different from those intended. 相似文献
19.
Alfred Philip James Lake BSc MBBS FFARCS ; Kathiravelpillai Puvanachandra MBBS DO FRCS FRCOphth 《Pain practice》2004,4(2):130-131
Abstract: Stellate ganglion block is commonly used to treat the sympathetically maintained pain which may occur in one‐third of patients with complex regional pain syndrome type 1. A complication that followed a single block and presented a diagnostic dilemma for the ophthalmologist is reported. 相似文献
20.