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71.
Lacombe P Rocha P Qanadli SD Guichoux F Pillière R El Hajjam M Foudali A Bourdarias JP Dubourg O 《European radiology》2002,12(4):915-919
We report a case of a 71-year-old man with a long coronary artery disease history and two sets of coronary artery bypass grafts. He developed large aortocoronary saphenous vein graft aneurysms in the two grafts from the first set of aortocoronary saphenous venous 20 years later. During the previous 3 years, the aneurysms grew in diameter from 22 to 50 mm. Because of severe renal insufficiency, and in order to avoid jeopardizing the late normal coronary artery bypass grafts by further thoracic surgery, we excluded successfully these altered grafts percutaneously by using 13 coils during the same procedure. 相似文献
72.
Objective
To evaluate the shear bond strength of one-step self-etch adhesives with different co-solvent ingredients to dry or moist dentin.Materials and methods
A total of 60 extracted teeth were used in this study, and were divided according to the adhesive systems and dentin conditions into 6 groups of 10 teeth each [Xeno III – dry dentin, Xeno III – moist dentin, Adper Prompot L-Pop – dry dentin, Adper Prompot L-Pop – moist dentin, iBond – dry dentin, and iBond – moist dentin]. Resin composite cylinder was built up on each specimen, and then thermocycled. A shear load was applied to the specimens using universal testing (Instron machine) at a cross-head speed of 0.5 mm/min until failure occurred. Data were statistically analyzed by one-way ANOVA and Bonferroni multiple comparison test at 95% confidence level.Results and conclusion
Based on the findings of this study: The highest mean shear bond strength to dry dentin was seen when Xeno III containing ethanol co-solvent ingredient was used. The highest mean shear bond strength to moist dentin was seen when iBond which contains acetone co-solvent ingredient was used. In the absence of a co-solvent ingredient in self-etch adhesive (Adper Prompot L-Pop), the mean shear bond strengths to dry and moist dentin were low with no significant difference between them. 相似文献73.
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76.
Tumor associated macrophages (TAM) are key pathogenic factors in neoplastic diseases. They are known to have plasticity and can polarize into two opposing phenotypes, including the tumoricidal M1 and the protumoral M2 phenotypes with high prevalence of M2-phentoypes in patients with poor prognosis. Strategies for targeting M2-TAM may consequently increase the efficacy of therapeutic strategies for cancer treatment. Gold nanorod-assisted plasmonic photothermal therapy (PPTT) has emerged as a promising treatment for cancer but the effects of macrophage polarization parameters in the performance of this new treatment modality is still unknown. Herein, human monocytic THP-1 cells were polarized into two opposite phenotypic macrophages (M1-TAM and M2-TAM) and their response to PPTT was examined. M2-TAM exhibits a three-fold increase in AuNP uptake compared to M1-TAM. Laser irradiation results in selective killing of pro-tumoral M2-TAM after treatment with AuNPs with limited effects on anti-tumoral M1-TAM. A positive correlation between the expression of CD206 marker and the AuNP uptake may indicate the role of CD206 in facilitating AuNP uptake. Our findings also suggest that the differences in AuNP avidity and uptake between the M1-TAM and M2-TAM phenotypes may be the rationale behind the effectiveness of PPTT in the treatment of solid tumors.A preferential uptake of gold nanoparticles by macrophages with a protumoral M2 phenotype result in efficient killing upon laser irradiation while keeping M1 phenotypes relatively undamaged. 相似文献
77.
Saud M. Elsaughier Ramadan Ghaleb Amr Salah Amin Khaled Sayed elmaghraby Khaled Abdelghany Baraka 《The Egyptian Heart Journal》2018,70(4)
Background
Patent ductus arteriosus is generally associated with hyperdynamic status. Given the vascular shunt between the aorta and pulmonary artery, intrinsic aortic changes occur (aortic stiffness). In the present study, we attempted to assess the impact of PDA on aortic stiffness and its connection with cardiovascular function before and after transcatheter closure of PDA.Patient and methods
Our study consisted of 60 children who were preparing for transcatheter closure of PDA and 60 healthy controls. All patients had clinical and echocardiographic proof of hemodynamically significant PDA.Results
Patients with PDA exhibited significantly higher ASI than controls before closure (p-value?<?0.05). After closure, ASI was significantly reduced (p-value?<?0.05), but still higher than that of controls (p-value?<?0.05) at the six-month follow-up assessment. Patients with PDA had significantly lower LVEF than controls before closure (p-value?<?0.05). After closure, LVEF was significantly enhanced (p-value?<?0.05), and no significant difference was noted amongst patients and controls (p-value?<?0.05) at the six-month follow-up assessment.Conclusion
Aortic stiffness is significantly increased in patients with PDA regardless of PDA size. Aortic stiffness is related to reduced heart function. ASI may be valuable for observing the course of patients with PDA before and after intervention. 相似文献78.
Ayman El-Garf Samia Salah Iman Iskander Hala Salah Sherif Naseh Amin 《Rheumatology international》2010,30(10):1293-1298
The objective of the study is to screen 12 MEFV gene mutations in Egyptian patients with familial Mediterranean fever (FMF)
and to study the initial hypothesis that the phenotypic expression of the disease may be attributable to the existence of
a particular mutation. We enrolled 136 Egyptian patients (74 males, and 62 females) with a clinical diagnosis of FMF. DNA
was amplified by PCR and subjected to reverse hybridization for the detection of 12 MEFV gene mutations. The phenotypic expression
of the disease was compared in two subgroups according to the presence of homozygote E148Q and M694V gene mutations. The most
frequent gene mutations in the studied group were V726A, M694V, M680I, E148Q and M694I in 41.2, 32.4, 29.4, 25 and 20.6%,
respectively. At least one of these main five founder mutations was present in 132 patients (97.1%). Thirty-two patients (23.5%)
were homozygote for one of the main five founder mutations. The most common homozygote gene mutations were E148Q and M694V,
each in 12 patients (8.8%). Significant increase in abdominal pain and arthritis was found in patients with homozygote M694V
mutation compared to those with E148Q mutation. All patients with amyloidosis had M694V gene mutation. The increased frequency
of V726A gene mutation and the rarity of amyloidosis in this study suggest that Egyptian patients may have a milder form of
FMF compared to other populations. The five main founder mutations account for the vast majority of cases of FMF. M694V gene
mutation may be associated with increased frequency of abdominal pain, arthritis and the presence of amyloidosis. 相似文献
79.
80.
Mohammed Al-Beltagi Nermin Kamal Saeed Adel Salah Bediwy Yasser El-Sawaf 《World journal of gastroenterology : WJG》2021,27(16):1716-1727
The coronavirus disease 2019 (COVID-19) pandemic is a threat worldwide for individuals of all ages, including children. Gastrointestinal manifestations could be the initial presenting manifestation in many patients, especially in children. These symptoms are more common in patients with severe disease than in patients with non-severe disease. Approximately 48.1% of patients had a stool sample that was positive for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) viral RNA. Children typically form 1%-8% of all laboratory-confirmed cases of SARS-CoV-2. Gastrointestinal manifestations of COVID-19 in children are not rare, with a prevalence between 0 and 88%, and a wide variety of presentations, including diarrhoea, vomiting, and abdominal pain, can develop before, with or after the development of respiratory symptoms. Atypical manifestations such as appendicitis or liver injury could also appear, especially in the presence of multisystem inflammatory disease. In this review, we discussed the epidemiology of COVID-19 gastrointestinal diseases in children as well as their implications on the diagnosis, misdiagnosis, prognosis, and faecal-oral transmission route of COVID-19 and the impact of gastrointestinal diseases on the gut microbiome, child nutrition, and disease management. 相似文献