全文获取类型
收费全文 | 612篇 |
免费 | 35篇 |
国内免费 | 4篇 |
专业分类
耳鼻咽喉 | 2篇 |
儿科学 | 18篇 |
妇产科学 | 2篇 |
基础医学 | 41篇 |
口腔科学 | 20篇 |
临床医学 | 99篇 |
内科学 | 142篇 |
皮肤病学 | 19篇 |
神经病学 | 5篇 |
特种医学 | 91篇 |
外科学 | 32篇 |
综合类 | 64篇 |
预防医学 | 48篇 |
眼科学 | 2篇 |
药学 | 28篇 |
1篇 | |
中国医学 | 19篇 |
肿瘤学 | 18篇 |
出版年
2024年 | 1篇 |
2023年 | 2篇 |
2022年 | 6篇 |
2021年 | 9篇 |
2020年 | 11篇 |
2019年 | 9篇 |
2018年 | 13篇 |
2017年 | 7篇 |
2016年 | 7篇 |
2015年 | 30篇 |
2014年 | 24篇 |
2013年 | 33篇 |
2012年 | 29篇 |
2011年 | 29篇 |
2010年 | 41篇 |
2009年 | 30篇 |
2008年 | 26篇 |
2007年 | 28篇 |
2006年 | 8篇 |
2005年 | 10篇 |
2004年 | 7篇 |
2003年 | 15篇 |
2002年 | 4篇 |
2001年 | 8篇 |
1999年 | 4篇 |
1998年 | 27篇 |
1997年 | 23篇 |
1996年 | 29篇 |
1995年 | 23篇 |
1994年 | 22篇 |
1993年 | 14篇 |
1992年 | 3篇 |
1991年 | 1篇 |
1990年 | 4篇 |
1989年 | 15篇 |
1988年 | 16篇 |
1987年 | 11篇 |
1986年 | 10篇 |
1985年 | 11篇 |
1984年 | 9篇 |
1983年 | 6篇 |
1982年 | 8篇 |
1981年 | 3篇 |
1980年 | 8篇 |
1979年 | 1篇 |
1978年 | 3篇 |
1977年 | 2篇 |
1976年 | 7篇 |
1975年 | 3篇 |
1954年 | 1篇 |
排序方式: 共有651条查询结果,搜索用时 281 毫秒
101.
TRAIL-receptor expression is an independent prognostic factor for survival in patients
with a primary glioblastoma multiforme 总被引:1,自引:0,他引:1
Kuijlen JM Mooij JJ Platteel I Hoving EW van der Graaf WT Span MM Hollema H den Dunnen WF 《Journal of neuro-oncology》2006,78(2):161-171
SummaryPurpose In order to improve the survival of patients with a glioblastoma multiforme tumor (GBM), new therapeutic strategies must be developed. The use of a death inducing ligand such as TRAIL (TNF Related Apoptosis Inducing Ligand) seems a promising innovative therapy. The aim of this study was to quantify the expression of the death regulating receptors TRAIL-R1, TRAIL-R2 and TRAIL on primary GBM specimens and to correlate this expression with survival.Experimental design Expression of TRAIL and TRAIL-receptors was assessed by immunohistochemistry, both quantitatively (% of positive tumor cells) and semi-quantitatively (staining intensity) within both the perinecrotic and intermediate tumor zones of primary GBM specimens. RT-PCR of GBM tissue was performed to show expression of TRAIL receptor mRNA.Results Immunohistochemistry showed a slight diffuse intracytoplasmic and a stronger membranous staining for TRAIL and TRAIL receptors in tumor cells. Semi-quantitative expression of TRAIL showed a significantly higher expression of TRAIL in the perinecrotic zone than in the intermediate zone of the tumor (P=0.0001). TRAIL-R2 expression was significantly higher expressed than TRAIL-R1 (P=0.005). The antigenic load of TRAIL-R2 was positively correlated with survival (P=0.02). Multivariate analysis of TRAIL-R1 within the study group (n=62) showed that age, gender, staining intensity, antigenic load, % of TRAIL-R1 expression, were not statistically correlated with survival however radiotherapy was significantly correlated (multivariate analysis: age: P=0.15; gender: P=0.64; staining intensity: P=0.17; antigenic load: P=0.056; % of TRAIL-R1 expression: P=0.058; radiotherapy: P=0.0001). Subgroup analysis of patients who had received radiotherapy (n=47) showed a significant association of % of TRAIL-R1 expression and the antigenic load of TRAIL-R1 with survival (multivariate analysis: P=0.036, respectively, P=0.023).Multivariate analysis of TRAIL-R2 staining intensity and antigenic load, within the study group (P=0.004, respectively, P=0.03) and the subgroup (P=0.002, respectively, P=0.004), showed a significant association with survival. RT-PCR analysis detected a negative relation between the amount of TRAIL-R1 mRNA and the WHO grade of astrocytic tumors (P=0.03).Conclusions TRAIL-R1 and TRAIL-R2 expression on tumor cells are independent prognostic factors for survival in patients with a glioblastoma multiforme. Both receptors could be targets for TRAIL therapy. As TRAIL-R2 is more expressed, in comparison with TRAIL-R1, on GBM tumor cells, TRAIL-R2 seems to be of more importance as a target for future TRAIL therapy than TRAIL-R1. 相似文献
102.
103.
Gallium-67 scintigraphy in multisystem malignant melanoma 总被引:1,自引:0,他引:1
104.
105.
目的 探索HO-1对肝脏缺血再灌注损伤中肥大细胞脱颗粒的影响。方法 将20只SD大鼠随机分成4组:假手术组(Sham组),缺血再灌注损伤组(I/RI组),HO-1诱导剂钴原卟啉组(CoPP组,术前24h给予CoPP,5 mg/kg)及HO-1抑制剂锌原卟啉组(ZnPP组,术前24h给予ZnPP,20 mg/kg)。建立大鼠缺血再灌注损伤模型,各组于再灌注后2h收集标本。RT-PCR检测肝脏组织HO-1 mRNA表达,Western blot检测肝脏组织HO-1蛋白表达;测定血清中ALT、AST水平;肝脏组织甲苯胺蓝染色检测肥大细胞脱颗粒数量,HE染色评价肝脏组织损伤情况。结果 与Sham组相比,I/RI组、CoPP组、ZnPP组大鼠组织HO-1 RNA和蛋白表达增加,血清ALT、AST水平升高,肥大细胞脱颗粒数量增多,肝脏细胞损伤加重。CoPP组与I/RI组相比,HO-1 mRNA和蛋白表达增加,血清ALT、AST水平减低,肥大细胞脱颗粒数量减少,肝细胞损伤减轻。ZnPP组与I/RI组相比,HO-1 mRNA和蛋白表达减少,血清ALT、AST水平升高,肥大细胞脱颗粒数量增多、肝细胞损伤严重。组间比较差异具有统计学意义(P<0.05)。结论 HO-1过表达能减轻肝脏I/RI,其机制可能与抑制肝脏组织中肥大细胞脱颗粒有关。 相似文献
106.
儿童失神性癫痫为儿童期癫痫最常见的类型,通常使用乙琥胺、丙戊酸或拉莫三嗪治疗。但这三种常用药,哪种效果最佳且儿童最易耐受仍然未知,本研究对此进行了考察。 相似文献
107.
目的 探讨乳腺癌术后化疗后放疗期间同期或序贯内分泌治疗的临床效果.方法 收集2003年1月~2007年1月本院行乳腺癌手术治疗且病理证明激素受体阳性的乳腺癌患者100例,将其分为同期组和序贯组,每组各50例.同期组给予化疗后放疗同期内分泌治疗,序贯组给予化疗后放疗序贯内分泌治疗.比较两组患者的临床疗效,随访统计两组患者毒副反应发生率及长期生存率.结果 同期组放射性肺炎、放射性肺纤维化、放射性皮肤纤维化发生率(分别为6.0%、10.0%、8.0%)与序贯组(分别为6.0%、8.0%、6.0%)比较,差异无统计学意义(P>0.05).同期组局部复发率(8.0%)、远处转移率(10.0%)及5年生存率(80.0%)与序贯组(分别为10.0%、14.0%、82.0%)比较,差异无统计学意义(P>0.05).结论 同期和序贯内分泌治疗并没有增加放疗的不良反应发生率,不会影响放疗的敏感性及总生存率. 相似文献
108.
Background
Fabrication of complete dentures requires the use of certain guidelines which are placed on the bite blocks to assist the clinician to have the maxillary anterior teeth restored to optimal dento-labial relations, in harmony with the overall facial appearance.Objective
To explore if any relationship exists between dental and facial proportions as well as the height of the individuals.Methods
Two hundred and four dental students of the Obafemi Awolowo University volunteered to participated in the study. The lower facial height, inter incisal, inter canine, and intercommisure distances, as well as the height of the participants were measured. The data were imputed, analyzed, and reported as simple frequency, means and standard deviations using the SPSS vs 11. Statistical significance was inferred at p<0.05.Result
The mean values of all the parameters measured were significantly higher in males than females. None of the mean values measured were coincident. However, a significant correlation exists between intercanine and interincisal distances(r=0.8) while a weak but significant negative correlation exists between the intercanine distance and the difference of the intercommisural and intercanine distances (r=−0.4)Conclusion
The study showed no relationship between intercanine distance, interincisal distance, lower facial height, and the height of the participants with the intercommissural distance. Hence, intercommissural distance may not be used in marking canine line during bite registration procedure. At best, 1.75–2.45 cm should be subtracted from the intercommissural distance to determine the intercanine distance. 相似文献109.