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991.
Al Shamsi M Al Samri MT Al-Salam S Conca W Shaban S Benedict S Tariq S Biradar AV Penefsky HS Asefa T Souid AK 《Chemical research in toxicology》2010,23(11):1796-1805
A novel in vitro system was developed to investigate the effects of two forms of calcined mesoporous silica particles (MCM41-cal and SBA15-cal) on cellular respiration of mouse tissues. O(2) consumption by lung, liver, kidney, spleen, and pancreatic tissues was unaffected by exposure to 200 μg/mL MCM41-cal or SBA15-cal for several hours. Normal tissue histology was confirmed by light microscopy. Intracellular accumulation of the particles in the studied tissues was evident by electron microscopy. The results show reasonable in vitro biocompatibility of the mesoporous silicas with murine tissue bioenergetics. 相似文献
992.
Christopher Lichtenwalter James A. de Lemos Michele Roesle Owen Obel Elizabeth M. Holper Donald Haagen Bilal Saeed Jose Miguel Iturbe Kendrick Shunk Joseph K. Bissett Rajesh Sachdeva Vassilios V. Voudris Panagiotis Karyofillis Biswajit Kar James Rossen Panayotis Fasseas Peter Berger Subhash Banerjee Emmanouil S. Brilakis 《JACC: Cardiovascular Interventions》2009,2(9):855-860
993.
Factors related to the dissemination and implementation of evidence-based practices (EBPs) are discussed. Extensive effort is required to successfully implement and sustain EBPs that improve clinical outcomes. There is a rapid rate of discovery of new EBPs. Examples of large-scale implementations of EBPs in mental health are described with emphasis on the factors thought critical for success. The need for designing systems which can cost-effectively implement new EBPs is highlighted. Finally, the implications for psychiatric administrators are discussed. 相似文献
994.
Gharibzadeh S Hosseini M Shoar S Hoseini SS 《The Journal of neuropsychiatry and clinical neurosciences》2010,22(4):451-m.e25-451.e25
995.
The mechanisms involved in biomineralization are modulated through interactions with organic matrix. In the case of stone
formation, the role of the organic macromolecules in the complex urinary environment is not clear, but the presence of mineralogical
‘signatures’ suggests that some aspects of stone formation may result from a non-classical crystallization process that is
induced by acidic proteins. An amorphous precursor has been detected in many biologically controlled mineralization reactions,
which is thought to be regulated by non-specific interactions between soluble acidic proteins and mineral ions. Using in vitro
model systems, we find that a liquid-phase amorphous mineral precursor induced by acidic polypeptides can lead to crystal
textures that resemble those found in Randall’s plaque and kidney stones. This polymer-induced liquid-precursor process leads
to agglomerates of coalesced mineral spherules, dense-packed spherulites with concentric laminations, mineral coatings and
‘cements’, and collagen-associated mineralization. Through the use of in vitro model systems, the mechanisms involved in the
formation of these crystallographic features may be resolved, enhancing our understanding of the potential role(s) that proteins
play in stone formation. 相似文献
996.
Shanaz Shalli M.D. Diyar Saeed M.D. Kiyotaka Fukamachi M.D. Ph.D. A. Marc Gillinov M.D. † William E. Cohn M.D. Ph.D. ‡ Louis P. Perrault M.D. Ph.D. § Edward M. Boyle M.D. ¶ 《Journal of cardiac surgery》2009,24(5):503-509
Abstract Background: Blood accumulating inside chest cavities can lead to serious complications if it is not drained properly. Because life-threatening conditions can result from chest tube occlusion after thoracic surgery, large-bore tubes are generally employed to optimize patency. Aims: The aim of this study was to better define problems with current paradigms for chest drainage. Materials and Methods: A survey was conducted of North American cardiothoracic surgeons and specialty cardiac surgery nurses. A total of 108 surgeons and 108 nurses responded. Results: The survey revealed that clogging leading to chest-tube dysfunction is a major concern when choosing tube size. Of surgeons responding, 106 of 106 (100%) had observed chest tube clogging, and 93 of 106 (87%) reported adverse patient outcomes from a clogged tube. Despite techniques such as tube stripping, tapping, and squeezing, up to 51% of surveyed surgeons stated they are not satisfied with currently available tubes and procedures to avoid tube occlusion and some even forbid the stripping maneuver for fear of causing more bleeding by the negative pressures generated. In addition, respondents noted that patients experience increasing discomfort with increasing drain size. Discussion: The major reason surgeons choose large-diameter chest tubes is linked to concern about the suboptimal available methods to avoid and treat chest-tube clogging. Even though larger tubes are thought to be associated with more pain, physicians generally err on the side of caution to avoid clogging and insert tubes with larger diameters. Conclusion: Results of this survey highlight the frequent problems with clogging with current postsurgical chest drainage systems and suggest the need for innovative solutions to avoid clogging complications and overcome clinician concern and patient pain. 相似文献
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Al-Naser S 《Injury》2008,39(8):963-964