全文获取类型
收费全文 | 1881篇 |
免费 | 57篇 |
国内免费 | 3篇 |
专业分类
耳鼻咽喉 | 7篇 |
儿科学 | 18篇 |
妇产科学 | 38篇 |
基础医学 | 204篇 |
口腔科学 | 24篇 |
临床医学 | 103篇 |
内科学 | 564篇 |
皮肤病学 | 7篇 |
神经病学 | 214篇 |
特种医学 | 64篇 |
外科学 | 264篇 |
综合类 | 6篇 |
预防医学 | 41篇 |
眼科学 | 16篇 |
药学 | 137篇 |
中国医学 | 5篇 |
肿瘤学 | 229篇 |
出版年
2022年 | 13篇 |
2021年 | 16篇 |
2018年 | 15篇 |
2017年 | 15篇 |
2016年 | 21篇 |
2015年 | 17篇 |
2014年 | 23篇 |
2013年 | 36篇 |
2012年 | 60篇 |
2011年 | 53篇 |
2010年 | 43篇 |
2009年 | 42篇 |
2008年 | 72篇 |
2007年 | 60篇 |
2006年 | 89篇 |
2005年 | 71篇 |
2004年 | 67篇 |
2003年 | 68篇 |
2002年 | 81篇 |
2001年 | 88篇 |
2000年 | 86篇 |
1999年 | 71篇 |
1998年 | 22篇 |
1997年 | 23篇 |
1996年 | 25篇 |
1995年 | 15篇 |
1994年 | 20篇 |
1993年 | 19篇 |
1992年 | 54篇 |
1991年 | 51篇 |
1990年 | 49篇 |
1989年 | 43篇 |
1988年 | 56篇 |
1987年 | 48篇 |
1986年 | 50篇 |
1985年 | 37篇 |
1984年 | 34篇 |
1983年 | 35篇 |
1982年 | 13篇 |
1981年 | 14篇 |
1979年 | 31篇 |
1978年 | 16篇 |
1977年 | 17篇 |
1976年 | 14篇 |
1974年 | 11篇 |
1972年 | 15篇 |
1969年 | 13篇 |
1968年 | 14篇 |
1967年 | 11篇 |
1966年 | 11篇 |
排序方式: 共有1941条查询结果,搜索用时 15 毫秒
41.
Koichi Okamoto Itasu Ninomiya Shogo Maruzen Hiroto Saito Tomoya Tsukada Jun Kinoshita Isamu Makino Keishi Nakamura Katsunobu Oyama Tomoharu Miyashita Hidehiro Tajima Hiroyuki Takamura Hirohisa Kitagawa Sachio Fushida Takashi Fujimura Tetsuo Ohta 《Esophagus》2014,11(2):89-98
Background
Tachyarrhythmia after esophagectomy is a severe complication that should not be underestimated because of its negative impact. The aims of this study were to clarify the cause and impact of postoperative tachyarrhythmia after thoracoscopic esophagectomy. Additionally, we analyzed the usefulness of landiolol administration for postoperative tachyarrhythmia.Methods
We evaluated the predictive factors for tachyarrhythmia onset after surgery and its clinical impact in 127 patients who underwent thoracoscopic esophagectomy with extended lymphadenectomy. Moreover, we analyzed the efficacy of landiolol for postoperative tachyarrhythmia.Results
Tachyarrhythmia developed in 38 of the 127 patients. Multivariate analysis showed that advanced age, heart disease, and hyperlipidemia were associated with postoperative tachyarrhythmia. Hyponatremia, hypoalbuminemia, and leukocytosis on postoperative day 3 were significantly associated with tachyarrhythmia onset. The incidence of all complications and respiratory complications, including pneumonia, was significantly higher in patients with than in those without tachyarrhythmia. The mortality rate in the tachyarrhythmia group tended to be higher than that in the nontachyarrhythmia group. Landiolol as a treatment for tachyarrhythmia immediately decreased heart rate and safely reduced subsequent respiratory complications.Conclusion
In elderly patients with cardiac disease or hyperlipidemia, surgeons should be alert for the occurrence of tachyarrhythmia after esophagectomy. Postoperative tachyarrhythmia is a marker of morbidities with particular emphasis on respiratory complications. However, it can be adequately managed by landiolol, resulting in fewer respiratory complications. Landiolol might be a safe and convenient agent for managing postoperative tachyarrhythmia after thoracoscopic esophagectomy, resulting in lower mortality and morbidity rates. 相似文献42.
Ishizawa J Mori T Tsukada Y Matsuki E Yokoyama K Shimizu T Sugita K Murata M Iwata S Okamoto S 《[Rinshō ketsueki] The Japanese journal of clinical hematology》2012,53(6):623-627
A 62-year-old man with diffuse large B-cell lymphoma received five courses of R-CHOP chemotherapy. The patient developed cellulitis in the bilateral lower extremities without fever, and blood culture yielded Helicobacter cinaedi after five-day culture. Although the response to tazobactam/piperacillin (TAZ/PIPC) was prompt, cellulitis recurred immediately after discontinuation of the drug. Even after two months of treatment with PIPC plus amikacin followed by amoxicillin, it recurred again soon after stopping the antibiotics. H. cinaedi reportedly causes bacteremia and cellulitis in immunocompromised patients mostly in patients with acquired immunodeficiency syndrome. Only sporadic cases have been reported in association with hematological malignancies. Physicians should be aware of H. cinaedi as one of the causative pathogens of bacteremia and cellulitis in patients with hematological malignancies. Longer incubation period of blood culture is needed to detect the microbe and long-term use of antimicrobials is required to prevent recurrent cellulitis. 相似文献
43.
Shigeaki Sawada Yutaka Shimada Shinichi Sekine Kazuto Shibuya Isaku Yoshioka Koshi Matsui Tomoyuki Okumura Toru Yoshida Takuya Nagata Hideyuki Uotani Kazuhiro Tsukada 《International surgery》2013,98(4):372-378
Although several reports have revealed that fluorine-18 fluorodeoxyglucose positron emission tomography (18F-FDG PET) is useful for differentiating between benign and malignant lesions in the gallbladder, the positive results of 18F-FDG PET are not specific for malignancy because 18F-FDG is also accumulated in inflammatory lesions. It is known that the most important pathway for 18F-FDG to enter the cell body is mediated by the facilitative glucose transporter-1 (GLUT-1) through GLUT-3. We herein present a case of xanthogranulomatous cholecystitis (XGC) with a positive result on 18F-FDG PET. In this case, GLUT-1 and GLUT-3 were both positively expressed in inflammatory cells at the gallbladder wall of XGC and this is the first report to reveal GLUT expression in XGC. This report reveals that surgeons should carefully consider the appropriate treatment of gallbladder tumor, even with a positive result on 18F-FDG PET. 相似文献
44.
Akira T. Kawaguchi Munetaka Haida Hiroyuki Ohba Mariko Yamano Dai Fukumoto Hideo Tsukada 《Artificial organs》2013,37(10):904-912
Liposome‐encapsulated hemoglobin (LEH) is protective early after brain ischemia in rats and nonhuman primates, but it remains unclear whether the protection persists and confers any benefits beyond the acute phase of brain ischemia and reperfusion. Ten monkeys underwent middle cerebral artery occlusion, received LEH (2 mL/kg, n = 5) or saline (2 mL/kg, n = 5) 5 min later, and reperfusion 3 h later. Positron emission tomography studies were repeated for the cerebral metabolic rate of O2 (CMRO2) as well as glucose (CMRglc) up to 8 days after reperfusion, when the animals were euthanized for morphological studies. There was no difference in O2 metabolism until 3 h after reperfusion, when CMRO2 was significantly better preserved in the cortex, but not in basal ganglia, on Day 0 in LEH‐treated monkeys. The extent of cortical infarction (saline 68 ± 10% vs. LEH 38 ± 9%, P < 0.05) and CMRO2 (mild suppression: saline 34 ± 10% vs. LEH 14 ± 4%, P < 0.05) remained significantly better preserved 8 days later, when CMRglc showed a similar pattern of cortical protection (mild suppression: saline 49 ± 15% vs. LEH 37 ± 4%, P < 0.05) in LEH‐treated monkeys, together with regained body weight. Somatic weight control, morphological integrity, CMRO2, and CMRglc were better preserved immediately, as well as 8 days after occlusion and reperfusion of the middle cerebral artery in monkeys receiving LEH early after onset of ischemia. 相似文献
45.
Tomoki Ueda Rioko Iino Kenji Yokoyama Shinichiro Okamoto Keiko Asakura Yuiko Tsukada Jo Ishizawa Eri Matsuki Yasuo Ikeda Yutaka Hattori 《International journal of hematology》2012,96(4):477-484
In order to test for improved survival following autologous transplantation (ASCT), we conducted a prospective clinical trial of post-ASCT thalidomide therapy in Japanese patients with multiple myeloma (MM). Twenty-five newly diagnosed patients received double or single ASCT with high-dose melphalan (200?mg/m2). Two months after stem cell infusion, if the patients failed to achieve a near-complete response, thalidomide was administered at 200?mg/day until disease progression or occurrence of intolerable adverse events. Seventeen patients were in partial response or minimal response after ASCT and received thalidomide alone. Their median progression-free survival (PFS) from ASCT was 17.4?months, and the median overall survival (OS) was 42.9?months. Some patients with normal karyotype experienced durable disease stabilization for over 5?years. Five patients who exhibited high-risk chromosomal changes such as t(4;14) or deletion of chromosome 13 or 17 showed very short PFS and OS compared with those who did not. Observed grade 3 or 4 toxicities included infection in three patients, hematological toxicities in three, and gastrointestinal toxicities in two, but there was no grade 3 or higher peripheral neuropathy, probably due to appropriate dose modifications. This long-term prospective study is the first to demonstrate the feasibility of post-ASCT thalidomide therapy in Japanese patients with MM. 相似文献
46.
Yosuke Miwa M.D. Hideaki Yoshino M.D. Kyoko Hoshida M.D. Mutsumi Miyakoshi M.D. Takehiro Tsukada M.D. Satoru Yusu M.D. Takanori Ikeda M.D. 《Annals of noninvasive electrocardiology》2012,17(3):260-267
Background: Previous studies have described the clinical usefulness of the presence of nonsustained ventricular tachycardia (NSVT) and defined heart rate turbulence (HRT) in stratifying patients at risk. We prospectively assessed whether HRT can facilitate the predictive accuracy of NSVT for identifying patients at risk for serious arrhythmic events in patients with left ventricular (LV) dysfunction. Methods: We enrolled 299 consecutive patients with LV dysfunction (ejection fraction ≤ 40%) including ischemic (n = 184) and nonischemic causes (n = 115). The presence of NSVT was assessed on Holter electrocardiograms (ECGs). HRT was simultaneously measured from Holter ECGs, assessing two parameters: turbulence onset (TO) and turbulence slope (TS). HRT was considered positive when both TO and TS were abnormal. The end point was defined as of sudden cardiac death (SCD) and sustained ventricular tachyarrhythmias (VTs). Results: NSVT was documented in 93 patients (32.7%). For HRT assessment, 17 patients (5.6%) were not utilized. Of 282 patients, 68 (24.1%) were HRT positive. During follow‐up of 960 ± 444 days, 14 patients (5.0%) reached the end point. NSVT, HRT, and diabetes were significantly associated with the end point. On multivariate analysis, NSVT had the strongest value for the end point, with an HR of 4.4 (95%CI, 1.4–14.3; P = 0.0138). When NSVT combined with HRT, the predictive accuracy is more increased, with an HR of 8.2 (95%CI, 2.9–23.3; P < 0.0001). The predictive values of the combination were higher than single use of NSVT or HRT. Conclusions: HRT can facilitate the predictive accuracy of NSVT for identifying patients at risk for serious arrhythmic events in patients with LV dysfunction. 相似文献
47.
Masataka Umeda Keita Fujikawa Tomoki Origuchi Toshiaki Tsukada Akira Kondo Shinya Tomari Yuichi Inoue Hisashi Soda Hideki Nakamura Shoko Matsui Atsushi Kawakami 《Modern rheumatology / the Japan Rheumatism Association》2012,22(6):919-923
We report a 72-year-old man with respiratory involvement of immunoglobulin G4 (IgG4)-related disease, who developed dry cough and shortness of breath on effort. The chest computed tomography scan image showed massive and diffuse ground-glass opacity, interlobular thickening, and bronchial wall thickening. The infiltration of IgG4-positive plasma cells in the transbronchial lung biopsy and high serum IgG4 concentrations were found. The patient was treated with 0.6?mg/kg oral prednisolone and showed rapid improvement. This is a case of IgG4-related disease in which the only complication was respiratory involvement. 相似文献
48.
Sachiyuki Tsukada Masaki Otsuji Akira Shiozaki Asako Yamamoto Shuro Komatsu Hideya Yoshimura Hiroo Ikeda Akiho Hoshino 《International orthopaedics》2013,37(12):2451-2456
Purpose
The reduction of periosteal compression through the use of a locking plate may minimize disturbances of bone blood supply and may improve the rate of bone union. A single-centre, assessor blinded randomized controlled trial was conducted to compare the clinical effectiveness of a locking plate and a non-locking plate.Methods
A total of 52 patients with AO/OTA 44B lateral malleolar fractures were included in this study. All patients underwent surgical fixation using a lag screw and neutralization plate. An identical treatment protocol was used in all patients, with exception of plate selection. The rate of radiographic bone union, defined as the complete disappearance of fracture lines confirmed through anteroposterior, lateral, and internal oblique views was compared at three, six, and 12 months following surgery. In addition, the Medical Outcomes 36-Item Short-Form Health Survey (SF-36) score, the time required for resolution of tenderness at the fracture site and the complication rate were evaluated.Results
Twenty-three patients were randomly assigned to undergo fixation using a locking plate, and 29 patients were assigned to undergo fixation using a non-locking plate. Intention-to-treat analysis showed no difference in the radiographic bone union rate of fibula, SF-36 score, the time for resolution of tenderness at the fracture site and complication rates.Conclusion
No differences were observed in patients with AO/OTA 44B lateral malleolar fractures undergoing fixation with a locking versus non-locking neutralization plate. 相似文献49.
Sachiyuki Tsukada Motohiro Wakui Munenori Matsueda 《Archives of orthopaedic and trauma surgery》2013,133(6):861-868
Background
The ceramic-on-ceramic (CoC)-bearing couple in total hip arthroplasty (THA) was developed to reduce the wear debris and osteolysis. Although the mechanical strength of third-generation ceramic has improved over previous generations, the risk of osteolysis and ceramic fracture is still an important concern.Methods
We studied 124 uncemented THAs with third-generation CoC-bearing couple implanted between 2000 and 2004. The ceramic liner and head were secured with the direct taper locking mechanism. One hundred and eleven hips were followed-up for minimum of 8 years, with an average follow-up period of 10.1 years (range 8.0–12.8 years). Patients were evaluated with a particular emphasis on the prevalence of the osteolysis and the ceramic fracture.Results
The survivorship with the end point as implant revision for any reason was 94.9 % (95 % confidence intervals 90.0–99.3 %) at 12.8 years. Revisions were performed because of one ceramic liner fracture, three dislocations, and two deep infections. No radiographic evidence of wear or osteolysis was observed. The preoperative Merle d’Aubigne and Postel hip score increased from 11.6 to 17.1.Conclusions
Patients, who received third-generation CoC THA had no detectable wear and osteolysis. One ceramic fracture occurred, and the main reason for revision was dislocation. 相似文献50.
Hiroyuki Ohba Norihiro Harada Shingo Nishiyama Takeharu Kakiuchi Yuichi Kimura Hideo Tsukada 《Journal of cerebral blood flow and metabolism》2013,33(1):85-90
We have developed a feedback-controlled bolus plus infusion (FC-B/I) method for monitoring the interaction between positron emission tomography (PET) ligands and their specific target molecules with PET. The usefulness of the FC-B/I method was evaluated by the direct interaction between [11C]raclopride, a dopamine D2 receptor (D2R) ligand, and cold raclopride (10 and 100 μg/kg) in the brains of conscious monkeys. The present results demonstrated that the FC-B/I method could achieve the equilibrium state of [11C]raclopride in the striatum of monkey brain, and also that the cold raclopride-induced reduction of [11C]raclopride binding to D2R was observed in a dose-dependent manner. Good correlations of distribution volume ratio of the striatum to cerebellum between the conventional bolus plus infusion (B/I) method and the FC-B/I method as well as between the conventional bolus injection method and the FC-B/I method were observed. These results indicated that the system could be a useful tool for the evaluation of interaction between drug candidates and their target molecules like enzymes, receptors, and transporters by using of their specific PET ligands. 相似文献