全文获取类型
收费全文 | 4883篇 |
免费 | 355篇 |
国内免费 | 31篇 |
专业分类
耳鼻咽喉 | 24篇 |
儿科学 | 131篇 |
妇产科学 | 90篇 |
基础医学 | 766篇 |
口腔科学 | 137篇 |
临床医学 | 463篇 |
内科学 | 1058篇 |
皮肤病学 | 108篇 |
神经病学 | 610篇 |
特种医学 | 139篇 |
外科学 | 444篇 |
综合类 | 21篇 |
预防医学 | 454篇 |
眼科学 | 67篇 |
药学 | 371篇 |
中国医学 | 6篇 |
肿瘤学 | 380篇 |
出版年
2024年 | 16篇 |
2023年 | 78篇 |
2022年 | 131篇 |
2021年 | 247篇 |
2020年 | 167篇 |
2019年 | 182篇 |
2018年 | 229篇 |
2017年 | 144篇 |
2016年 | 172篇 |
2015年 | 210篇 |
2014年 | 261篇 |
2013年 | 321篇 |
2012年 | 468篇 |
2011年 | 439篇 |
2010年 | 241篇 |
2009年 | 185篇 |
2008年 | 293篇 |
2007年 | 325篇 |
2006年 | 253篇 |
2005年 | 249篇 |
2004年 | 223篇 |
2003年 | 154篇 |
2002年 | 136篇 |
2001年 | 18篇 |
2000年 | 8篇 |
1999年 | 25篇 |
1998年 | 18篇 |
1997年 | 21篇 |
1996年 | 12篇 |
1995年 | 7篇 |
1994年 | 15篇 |
1993年 | 7篇 |
1992年 | 3篇 |
1991年 | 2篇 |
1990年 | 2篇 |
1989年 | 3篇 |
1986年 | 1篇 |
1983年 | 1篇 |
1972年 | 1篇 |
1971年 | 1篇 |
排序方式: 共有5269条查询结果,搜索用时 31 毫秒
991.
Ansaldi F Bacilieri S Durando P Sticchi L Valle L Montomoli E Icardi G Gasparini R Crovari P 《Vaccine》2008,26(12):1525-1529
Adjuvants enhance antibody response against vaccination. We compared the ability of MF59-adjuvanted and non-adjuvanted subunit influenza vaccines, containing A/Wyoming/3/03(H3N2), to confer cross-protection against four consecutive drifted strains in the elderly. Neutralizing and haemagglutination-inhibiting antibody were measured. MF59-adjuvanted vaccine induced a stronger booster response against A/Panama/2007/99(H3N2) than non-adjuvanted vaccine. A/Panama/2007/99(H3N2) circulated widely during the previous 5 years and was included in vaccines over four consecutive seasons. Broader serological protection against drifted strains that circulated 1 and 2 years after vaccination with A/Wyoming/3/03(H3N2) was observed with MF59-adjuvanted vaccine. Thus, MF59-adjuvanted vaccine confers greater immunogenicity than non-adjuvanted vaccines in vulnerable populations. 相似文献
992.
The quality of life in genetic neuromuscular disease questionnaire: Rasch validation of the French version 下载免费PDF全文
Antoine Dany PT PhD Amandine Rapin MD MSc Brice Lavrard MD Virginie Saoût MD Christian Réveillère PhD Guillaume Bassez MD PhD Vincent Tiffreau MD PhD Yann Péréon MD PhD Sabrina Sacconi MD PhD Bruno Eymard MD PhD Moustapha Dramé MD PhD Damien Jolly MD PhD Jean‐Luc Novella MD PhD Jean‐Benoit Hardouin PhD François C. Boyer MD PhD 《Muscle & nerve》2017,56(6):1085-1091
993.
Sabrina Paganoni MD PhD Katie Nicholson MD Fawn Leigh MD Kathryn Swoboda MD David Chad MD Kristin Drake MS MBA Kellen Haley BA Merit Cudkowicz MD MSc James D. Berry MD MPH 《Muscle & nerve》2017,56(5):848-858
Multidisciplinary care is considered the standard of care for both adult and pediatric neuromuscular disorders and has been associated with improved quality of life, resource utilization, and health outcomes. Multidisciplinary care is delivered in multidisciplinary clinics that coordinate care across multiple specialties by reducing travel burden and streamlining care. In addition, the multidisciplinary care setting facilitates the integration of clinical research, patient advocacy, and care innovation (e.g., telehealth). Yet, multidisciplinary care requires substantial commitment of staff time and resources. We calculated personnel costs in our ALS clinic in 2015 and found an average cost per patient visit of $580, of which only 45% was covered by insurance reimbursement. In this review, we will describe classic and emerging concepts in multidisciplinary care models for adult and pediatric neuromuscular disease. We will then explore the financial impact of multidisciplinary care with emphasis on sustainability and metrics to demonstrate quality and value. Muscle Nerve 56 : 848–858, 2017 相似文献
994.
Vitamin D levels are associated with gross motor function in amyotrophic lateral sclerosis 下载免费PDF全文
995.
Kayla M.D. Cornett MSc Manoj P. Menezes MD PhD Rosemary R. Shy MD Isabella Moroni MD Emanuela Pagliano MD Davide Pareyson MD Timothy Estilow OTR/L Sabrina W. Yum MD Trupti Bhandari PT Francesco Muntoni MD FRCPCH Matilde Laura PhD Mary M. Reilly MD FRCP Richard S. Finkel MD Kate J. Eichinger DPT David N. Herrmann MBBCh Paula Bray PhD Mark Halaki PhD Michael E. Shy MD Joshua Burns PhD for the CMTPedS Study Group 《Annals of neurology》2017,82(3):353-359
996.
Tamishka De Silva Anjali Prakash Sandhya Yarlagadda Marjia Daniella Johns Kate Sandy Vibeke Hansen Sue Phelan Sabrina Pit 《International journal of mental health systems》2017,11(1):54
Background
Rural communities in Australia face significant disadvantages relating to geographical isolation and limited access to mental health services. Documenting general practitioners’ (GP) experiences and perception of mental health services in rural Australia may be useful to gain insight into rural GP management of mild to moderate depression.Aims
To explore GPs’ experience and views on which factors influence access to mental health services for mild to moderate depression.Method
This qualitative study was conducted in 2014 in the Northern Rivers, NSW, Australia. Data were obtained from semi-structured in-depth face-to-face interviews with ten GPs, and analyses were performed using a general inductive method of thematic analysis.Results
Most GPs believed that the current services for managing mild-moderate depression were adequate, however they also identified the need for better access and more services that were free for patients. GPs had a positive perception of management of depression in a rural setting, identifying advantages including better doctor-patient relationships, continuity of care and the proximity of services. However, GPs also identified several barriers to access to mental health services in a rural setting, including long waiting-times, inadequate patient rapport with referred professionals, cost of treatment, transportation, geographical location, stigma, and lack of education about available mental health services. As a result, GPs frequently self-managed patients in addition to referring them to other community mental health service providers where possible.Conclusion
Overall, GPs appeared relatively satisfied with the resources available in their communities but also identified numerous barriers to access and room for improvement. Rural GPs often self-managed patients in addition to referring patients to other mental health services providers. This should be taken into account when designing mental health policies, developing new services or re-designing current services in rural communities.997.
ECG morphology of premature ventricular contractions predicts the presence of myocardial fibrotic substrate on cardiac magnetic resonance imaging in patients undergoing ablation 下载免费PDF全文
998.
Sabrina M. Darrow Erin C. Accurso Emily R. Nauman Andrea B. Goldschmidt Daniel Le Grange 《European eating disorders review》2017,25(5):389-396
While many studies have explored the relationship between different eating disorder diagnoses and the familial social environment, current evidence does not support associations between distinct family interaction patterns (e.g. high enmeshment) and particular diagnoses (e.g. anorexia nervosa). The current study seeks to move beyond the current literature to explore whether empirically derived subtypes of family environment are associated with clinical features within a transdiagnostic sample of youth seeking treatment for eating disorders (n = 123). Latent class modelling of the Family Environment Scale identified three classes (i.e. different Family Environment Scale profiles): (1) Control‐Oriented; (2) System Maintenance‐Oriented; and (3) Conflict‐Oriented. Data are presented to characterize the classes (e.g. age, gender, rates of different eating disorders, severity of eating disorder pathology and rates of comorbid disorders). These preliminary results suggest that family interaction types may help personalize treatment for eating disorders and encourage future research to guide such efforts. Copyright © 2017 John Wiley & Sons, Ltd and Eating Disorders Association. 相似文献
999.
Gennaro Daniele Domenica Lorusso Giovanni Scambia Sabrina C. Cecere Maria Ornella Nicoletto Enrico Breda Nicoletta Colombo Grazia Artioli Lucia Cannella Giovanni Lo Re Francesco Raspagliesi Giuseppa Maltese Vanda Salutari Gabriella Ferrandina Stefano Greggi Alessandra Baldoni Alice Bergamini Maria Carmela Piccirillo Sandro Pignata 《Gynecologic oncology》2017,144(2):256-259
Background
Few data are available on the outcome of surgery after a bevacizumab-containing regimen. The MITO 16A- MaNGO OV2A phase 4 trial evaluates the outcomes of first-line CPB in a clinical-practice-like setting. Here we present the results of the subgroup of patients undergoing IDS after neoadjuvant treatment or suboptimal primary surgery.Methods
400 chemonaïve epithelial ovarian cancer patients, age ≥ 18, ECOG PS 0–2 were eligible to receive C (AUC 5 d1, q21) plus P (175 mg/m2 d1, q21) and B (15 mg/kg d1 q21) for 6 cycles followed by B maintenance until cycle 22nd.Results
79 patients (20%) underwent IDS. Overall, 74 patients received at least one administration of B before IDS. Median age was 61.2, 70% of the patients had FIGO IIIC disease. The median number of cycles before IDS was 3 both for chemotherapy and bevacizumab respectively. A residual disease ≤ 1 cm was achieved in 64 patients (86.5%). Four percent of the patients experienced fever and 4% required blood transfusion after surgery. Surgical wound infection and/or dehiscence, pelvic abscess, intestinal sub-occlusion and fistula were experienced by one patient each.Conclusions
In the MITO16A-MaNGO OV2A phase 4 trial, combined chemotherapy and bevacizumab did not hamper IDS and the rate of perioperative complications was similar to what expected without bevacizumab. These data support the hypothesis that adding bevacizumab to first line chemotherapy for ovarian cancer might not be denied to patients for whom IDS is planned. 相似文献1000.
Uterine,but not ovarian,female reproductive organ involvement at presentation by diffuse large B‐cell lymphoma is associated with poor outcomes and a high frequency of secondary CNS involvement 下载免费PDF全文
Tarec Christoffer El‐Galaly Chan Y. Cheah Martin Hutchings Nabegh George Mikhaeel Kerry J. Savage Laurie H. Sehn Sally Barrington Jakob W. Hansen Mette Ø. Poulsen Daniel Smith Kirsty Rady Karen J. Mylam Thomas S. Larsen Staffan Holmberg Maja B. Juul Sabrina Cordua Michael R. Clausen Kristina B. Jensen Martin Bøgsted Hans E. Johnsen John F. Seymour Joseph M. Connors Peter d. N. Brown Diego Villa 《British journal of haematology》2016,175(5):876-883
Involvement of the internal female reproductive organs by diffuse large B‐cell lymphoma (DLBCL) is uncommon, and there are sparse data describing the outcomes of such cases. In total, 678 female patients with DLBCL staged with positron emission tomography/computed tomography and treated with rituximab‐containing chemotherapy were identified from databases in Denmark, Great Britain, Australia, and Canada. Overall, 27/678 (4%) had internal reproductive organ involvement: uterus (n = 14), ovaries (n = 10) or both (n = 3). In multivariate analysis, women with uterine DLBCL experienced inferior progression‐free survival and overall survival compared to those without reproductive organ involvement, whereas ovarian DLBCL was not predictive of outcome. Secondary central nervous system (CNS) involvement (SCNS) occurred in 7/17 (41%) women with uterine DLBCL (two patients with concomitant ovarian DLBCL) and 0/10 women with ovarian DLBCL without concomitant uterine involvement. In multivariate analysis adjusted for other risk factors for SCNS, uterine involvement by DLBCL remained strongly associated with SCNS (Hazard ratio 14·13, 95% confidence interval 5·09–39·25, P < 0·001). Because involvement of the uterus by DLBCL appears to be associated with a high risk of SCNS, those patients should be considered for CNS staging and prophylaxis. However, more studies are needed to determine whether the increased risk of secondary CNS involvement also applies to women with localized reproductive organ DLBCL. 相似文献