Macrocarposide, a new isoflavanone c-glucoside from Pterocarpus macrocarpus heart wood

Macrocarposide has been isolated for the first time as a natural product from the heartwood of PTEROCARPUS MACROCARPUS along with some known compounds. Based on its spectral and chemical evidence, it has been assigned the structure dalbergioidin-6- C-glucoside ( 1).     

A case study: lennox hill bracing for postoperative total knee replacement

Traditionally, the use of the Lennox Hill derotation brace has primarily been for the management of sports related injuries. From the professional to the weekend athlete, or the patient who must return to a demanding occupation, the Lennox Hill brace has been utilized preoperatively and/or postoperatively to manage various knee disorders. In this case report, the Lennox Hill derotation brace was employed to manage post-total knee replacement pain and instability in a geriatric patient. Of particular interest in this case, also, is an increase in quadriceps strength with the Lennox Hill brace being worn versus quadriceps strength with traditional hinge bracing and without brace being worn.J Orthop Sports Phys Ther 1984;5(5):265-268.     

More data on major depression as an antecedent risk factor for first onset of chronic back pain

BACKGROUND: Few epidemiological studies have examined the temporal relationship between chronic pain and depression using longitudinal data. In the present study, we examined major depression as both an antecedent risk factor and consequence of chronic back pain (CBP) in the general population. METHOD: Data on 9909 pain-free individuals 15 years and older with no history of back problems were drawn from cycle 1 of the National Population Health Survey and followed up 24 months later. Major depression was assessed using a structured diagnostic interview. RESULTS: At cycle 2, the rate of new cases of CBP in persons who were depressed at cycle 1 was 3.6% compared to 1.1% in non-depressed persons. Compared to pain-free individuals, new cases of CBP were more likely to perceive their health status as poor or fair at cycle 1, were less likely to be working, reported more chronic health problems, and sustained a back or neck injury in the preceding 12 months. After controlling for other factors, pain-free individuals diagnosed as major depressed at cycle 1 were almost three times more likely (OR 2.9, 95% CI 1.2-7.0) to develop CBP at cycle 2. CONCLUSIONS: Consistent with other longitudinal studies major depression increases the risk of developing future chronic pain. The causal mechanism linking these conditions is unknown however depression may represent a modifiable risk factor in the development of CBP.     

Percutaneous coronary angioscopy: methods, findings, and therapeutic implications

The development and clinical implementation of percutaneous coronary angioscopy represents an engineering triumph, blending the newest technologies and materials in the field of fiberoptics with the most advanced techniques of balloon angioplasty catheter materials and construction. Current devices provide a safe method for acquiring excellent quality images of the coronary arteries. This is due to major advances in catheter alignment techniques allowing coaxial positioning of the angioscope in the relatively tortuous coronary arteries. Additional development is needed to further refine the degree of operator control over the field of view, which would also reduce procedure duration. The percutaneous coronary angioscope is currently a functional device for investigators attempting to correlate the morphology of atherosclerotic lesions and clinical coronary artery disease. Confirmation of the value of the angioscope as a clinically useful device for routine application in the diagnosis and management of cardiovascular disease will depend upon the results of further studies.     

Chronic anterior dislocation of the shoulder

The treatment of 17 chronic, unreduced anterior dislocations of the shoulder was reviewed. Eleven women and six men with on average age of 67 years (range 36 to 88 years) were studied. The duration of dislocation averaged 2.3 years (8 weeks to 8 years). Seven patients were treated without surgery despite severe functional deficits, for reasons of health or motivation. Ten were treated with surgery. One patient with preserved joint surfaces underwent open reduction and corticoid transfer to bone graft an eroded anterior glenoid. Nine patients with destroyed articular surfaces underwent unconstrained replacement orthroplosty. Humeral retroversion was increased for stability. The soft tissues were reattached, and rehabilitation was modified as with a repair of recurrent dislocations. Anterior glenoid erosion was often present and required bone grafting to support the glenoid component in four shoulders. Two chronic rotator cuff tears required repair. Nine patients were followed from 2 to 6 years, with an average of 3.9 years. The results were four excellent, four satisfactory, and one unsatisfactory. Although the reconstruction is complex, the surgical results were clearly superior to those of the nonoperative group.