川芎嗪在兔体内代谢产物的研究

应用高效液相色谱法将川芎嗪在家兔血液中的代谢产物进行分离,对原药及两种代谢产物进行了紫外、红外、质谱、核磁共振等光谱分析,推断出川芎嗪代谢产物的结构,并用化学方法合成了代谢物对照品,对其结构进一步得到验证。     

Morgagni: His book, vision and views on hepatic coma

The study of pathological anatomy reached a culmination in the magnum opus of Morgagni, The Seats and Causes of Diseases. It represented an innovative way of looking at the patient and his illness, a change that Foucault described as occurring in the 18th century. Physicians saw symptoms penetrating the body and converging upon an organ. We suggest that Morgagni and his fellow workers derived their vision from the practice of visual perspective discovered by Italian Renaissance artists. Perceiving in three dimensional terms, Morgagni added spatial depth to our understanding of disease. His acute vision was brilliantly displayed in his views of hepatic coma. He was among the first to provide the clinical-pathological associations of acute liver failure. The limitations of gross morphology precluded a complete elucidation of the disorder.     

Small intestine ischemia simulating primary colonic disease

Clinical and radiographic findings were reviewed for four patients in whom colonic diverticulitis was suspected clinically but in whom small intestine ischemia was proved surgically. In each patient the initial diagnostic studies--plain abdominal radiography and barium enema examination--revealed generalized small intestine distention and non-specific colonic abnormalities, respectively. The latter findings consisted of an extrinsic impression on the superior or inferior aspect of the sigmoid colon with associated thumbprinting or spiculation. In each patient serosal inflammation of the sigmoid colon produced by an adherent segment of the ischemic small intestine was confirmed at laparotomy. In two patients, delay in surgical intervention resulted in small intestine necrosis. In a patient who has clinical signs and symptoms of colonic ischemia, diverticulitis, or small intestine obstruction but nonspecific findings on barium studies, the diagnosis of small intestine ischemia should be considered and further diagnostic imaging, such as angiography or small intestine follow-through examination, should be performed.     

Anxiolytic property of Lactuca sativa,effect on anxiety behaviour induced by novel food and height

ObjectiveTo study anxiolytic property of hydro alchohol extract and to estimate polyphenols present in the extract by HPLC.MethodsTo evaluate anxiolytic property two animal models were used viz. Elevated T maze and hyponeophagia. Diazepam (1 mg/kg body wt.) served as the standard anxiolytic agent for all the tests. The dried extract of the plant leaf in doses of 100, 200 and 400 mg/kg body weight was administered orally to mice for duration of 15 or 30 days and locomotor and anxiolytic activities were performed. Polyphenols was estimated using HPLC.ResultsThe HPLC analysis of the polyphenols revealed the presence chlorogenic acid, vanillin, epicatechin, caffeic acid, rutin hydrate, sinapic acid, quercetin-3-rhamnoside, p-coumeric acid and quercitin. Time spent and number of entries into the open arm was improved in 30 days treated animals than that of 15 days treated groups, 200 and 400 mg/kg body weight treated group showed significant results when comparing with the control group.ConclusionsThe hydro alcohol extract rich in Polyphenols and other secondary metabolites is a potent anxiolytic agent.