全文获取类型
收费全文 | 277篇 |
免费 | 18篇 |
国内免费 | 7篇 |
专业分类
耳鼻咽喉 | 4篇 |
儿科学 | 14篇 |
妇产科学 | 6篇 |
基础医学 | 23篇 |
口腔科学 | 5篇 |
临床医学 | 27篇 |
内科学 | 87篇 |
皮肤病学 | 4篇 |
神经病学 | 7篇 |
特种医学 | 1篇 |
外科学 | 52篇 |
综合类 | 11篇 |
预防医学 | 22篇 |
眼科学 | 7篇 |
药学 | 20篇 |
中国医学 | 1篇 |
肿瘤学 | 11篇 |
出版年
2021年 | 4篇 |
2020年 | 2篇 |
2018年 | 2篇 |
2016年 | 2篇 |
2015年 | 7篇 |
2014年 | 3篇 |
2013年 | 4篇 |
2012年 | 1篇 |
2011年 | 7篇 |
2010年 | 12篇 |
2009年 | 15篇 |
2008年 | 5篇 |
2007年 | 6篇 |
2006年 | 11篇 |
2005年 | 1篇 |
2004年 | 5篇 |
2003年 | 10篇 |
2002年 | 9篇 |
2001年 | 5篇 |
2000年 | 2篇 |
1999年 | 5篇 |
1998年 | 18篇 |
1997年 | 7篇 |
1996年 | 10篇 |
1995年 | 14篇 |
1994年 | 10篇 |
1993年 | 6篇 |
1992年 | 11篇 |
1991年 | 4篇 |
1990年 | 8篇 |
1989年 | 5篇 |
1988年 | 6篇 |
1987年 | 12篇 |
1986年 | 8篇 |
1985年 | 6篇 |
1984年 | 3篇 |
1982年 | 2篇 |
1981年 | 3篇 |
1980年 | 1篇 |
1979年 | 7篇 |
1978年 | 3篇 |
1965年 | 5篇 |
1959年 | 1篇 |
1958年 | 7篇 |
1957年 | 3篇 |
1956年 | 1篇 |
1955年 | 8篇 |
1954年 | 5篇 |
1949年 | 4篇 |
1948年 | 4篇 |
排序方式: 共有302条查询结果,搜索用时 15 毫秒
31.
NICHOLAS J TALLEY SK LAM KL GOH KM FOCK 《Journal of gastroenterology and hepatology》1998,13(4):335-353
Dyspepsia is most optimally defined as pain or discomfort centred in the upper abdomen. The symptom complex may be caused by peptic ulcer disease, gastro-oesophageal reflux, or gastric cancer but is most often due to functional (or non-ulcer) dyspepsia. While upper endoscopy is the method of choice to determine the underlying cause of dyspepsia, it is expensive. A more pragmatic approach is needed in the Asia-Pacific region where health services are limited. A detailed treatment algorithm is given for managing patients presenting with new-onset dyspepsia and documented functional dyspepsia after endoscopy, and evidence to support this approach is reviewed. Prompt endoscopy is recommended for patients with alarm features. In patients without alarm features, treatment for 2–4 weeks with an empirical anti-secretory or prokinetic agent, followed by investigation using non-invasive Helicobacter pylori testing and treatment for patients who do not respond or relapse, is recommended. Trials of management strategies are now needed to establish the efficacy and cost-effectiveness of the approaches recommended. 相似文献
32.
Ultrasonography of 4 cases of intussusception in children with proven lead points were reviewed retrospectively. The lead points were due to lymphosarcoma, inverted Meckel's diverticulum, jejunal polyps and an inverted appendiceal stump. The lead points form a complex mass in the centre of the intussusception in both transverse and longitudinal sections, distinct from primary intussusception. The presence of such ultra-sonographic findings are suggestive of secondary intussusception with a lead point and surgical reduction rather than hydrostatic reduction should be considered. 相似文献
33.
WM WONG SK LAM TSM TONG KL CHEUNG VSY TANG HHX XIA KC LAI WHC HU CK CHAN MF YUEN AOO CHAN BCY WONG 《Journal of digestive diseases》2003,4(3):132-135
OBJECTIVE: To evaluate the accuracy of a rapid assay that wasdeveloped to detect Helicobacter pylori antigen in the stool,using the principle of immunochromatography, in the Chinese population. METHODS: Eligible patients without prior treatment of H.pylori were recruited. An in‐house rapid urease test (RUT) andhistology were used as the gold standard. The results of the rapidstool antigen test were compared with the gold standard. RESULTS: Valid rapid stool antigen test results for interpretationwere obtained from 94 consecutive patients (mean age: 52.5, range:22?82 years). Sensitivity, specificity, positive predictivevalue, negative predictive value and accuracy were, respectively, 77.5%,87.0%, 81.6%, 83.9% and 83.0%.The test was easy to perform and results were available within 15 min. CONCLUSION: The rapid stool antigen test using immunochromatography accuratelydiagnoses H. pylori infection in Chinese patients. 相似文献
34.
35.
36.
BENJAMIN CHUN-YU WONG SHIU-KUM LAM 《Journal of gastroenterology and hepatology》1998,13(Z3):S166-S172
Abstract Gastric cancer is the second most common fatal malignancy in the world. In China, gastric cancer is now the second most common malignancy, while in Hong Kong, the mortality rate ranked fourth among all cancers in 1995. Dietary factors in gastric carcinogenesis came mostly from case-control studies. N-Nitroso compounds from dietary sources such as preserved, smoked and salted foods were found to be associated with gastric cancer. ß-Carotene, selenium and α-tocopherol have been shown in an intervention study to be favourable in the reduction of stomach cancer mortality. Fruits and vegetables showed the most consistent results of inverse association with gastric cancer. Dietary salt intake in preserved or salted foods is also shown to be associated with gastric cancer. Tea drinking, especially green tea, has a protective effect against gastric cancer as shown in some studies. Prospective case-control studies of the association between Helicobacter pylori infection and the subsequent development of gastric cancer showed that the odds ratio ranged from 2.8 to 6.0. However, results of similar case-control studies in countries with a high frequency of gastric cancer are controversial. Infection with H. pylori leads to changes in the vitamin C content of gastric juice, reactive oxygen metabolites, epithelial cell proliferation and apoptosis. Recently, CagA-positive strains were found to be associated with gastric cancer and also duodenal ulcers. The exact role of H. pylori in gastric carcinogenesis is still under investigation. Large-scale intervention studies are underway to examine dietary supplementation, H. pylori infection and gastric cancer. Helicobacter pylori eradication for gastric cancer prevention is being conducted in China and other parts of the world. In high-risk areas, for example in China, a combination approach including H. pylori eradication and dietary supplementation may be necessary. 相似文献
37.
C. H. CHO B. W. CHEN W. M. HUI S. K. LAM C. W. OGLE 《Journal of gastroenterology and hepatology》1992,7(2):178-183
The role of vagus in the actions of different acid inhibitors on ethanol-induced gastric damage and mucosal blood flow (GMBF) changes was studied in anaesthetized rats, using an ex vivo stomach chamber preparation. Subdiaphragmatic bilateral vagotomy decreased the basal gastric acid secretion and GMBF; it also intensified ethanol-evoked lesions in the glandular mucosa. Misoprostol, omeprazole and cimetidine produced a similar degree of reduction in acid output. Misoprostol given subcutaneously (s.c.) (50 micrograms/kg), or added to the incubation solution (12.5 micrograms) for 15 min, markedly prevented ethanol-induced lesion formation and reduction in GMBF. The reversing effect of s.c. injection of misoprostol on either lesion formation or on GMBF reduction was attenuated by vagotomy. Omeprazole protected against lesion formation only when present in the incubation solution (12.5 mg) of ex vivo chamber preparations of both vagus-intact and vagotomized animals, but the effect was significantly less in the latter group. The drug also prevented the depressive action of ethanol in vagus-intact animals. Cimetidine pretreatment (50 mg s.c. or 12.5 mg in incubation solution), however, did not modify the effects of ethanol on lesion formation and the GMBF. The findings indicate that the three different types of acid inhibitors exert different actions on ethanol-induced gastric mucosal damage, although they produced similar inhibition of acid output. Vagotomy lowers the GMBF and attenuates the antiulcer action of misoprostol and omeprazole, especially when the drugs are given by the parenteral route. 相似文献
38.
R. O. JOHNSON B. H. JOHNSON A. RAMAN E. L. LEE K. L. LAM 《Journal of paediatrics and child health》1979,15(2):101-106
Johnson, R. O., Johnson, B. H., Raman, A., Lee, E. L., and Lam, K. L. (1979) Aust. Paediatr. J. , 15, 101–106. Metabolic acidosis and renal solute load in relation to the protein intake of low birth weight Malaysian neonates. Thirty-one low birth weight Malaysian neonates were divided into two groups for the purpose of comparing two different dilutions of modified cow's milk. One dilution supplied 2.4 g protein/100 kcal (16.9 g/l) and the other 3.3 g/100 kcal (22.5 g/l). The two milks were iso-caloric at 69 kcal/100 ml. Clinical observation and weekly estimations of acid-base status, plasma sodium, chloride, potassium, urea and osmolality and of urine osmolality were made during the first three weeks of life. Metabolic acidosis was observed in both groups of infants, being significantly more severe in the higher protein group. Most acidotic babies remained asymptomatic. Plasma urea and plasma and urine osmolalities were all significantly higher in the higher protein group. No case of hyperosmolality occurred. Caution is recommended when feeding cow's milk of protein density greater than 2.4 g/100 kcal to low birth weight infants. 相似文献
39.
40.