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11.
SUSUMU ITO HIROHITO HONDA SHINGO HIBINO CHIYO NII MASAKO KAMAMURA TOMOKO NISHIKADO HARUNOBU FUJIKAWA TETSUYA SAIJO SEISUKE OKAMURA ICHIRO SHIMIZU 《Journal of gastroenterology and hepatology》1994,9(1):19-25
Abstract After adoption of the anti-hepatitis C virus (C100-3) test, the incidences of definite and suspected cases of post-transfusional hepatitis (PTH) were 3.3% (7/209) and 7.2% (15/209), respectively. Four patients with definite PTH and seven patients with suspected PTH became positive for hepatitis C virus (HCV)-related antibodies or HCV-RNA after transfusion. These cases that became positive for anti-HCV or HCV-RNA showed a peak of alanine aminotransferase (ALT) more than 4 weeks after operation. Only rare cases that showed ALT peaks within 4 weeks after operation became positive for HCV-related antibodies or HCV-RNA. The peak ALT levels in cases showing positive conversion tended to be higher than those in cases showing no conversion. Judging from these results, cases of suspected PTH include those of transient liver disease attributable to surgery as well as clear cases of HCV infection. Thus new diagnostic criteria are required including data on HCV antibodies or HCV-RNA. 相似文献
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SUNAO KAWANO SHINGO TSUJI NOBUHIKO HAYASHI YOSHIYUKI TAKEI KOUICHI NAGANO HIDEYUKI FUSAMOTO TAKENOBU KAMADA 《Journal of gastroenterology and hepatology》1995,10(1):81-85
Abstract Non-steroidal anti-inflammatory drugs (NSAID) are, and have been, frequently used for alleviation of pain in patients; however, they are known to cause gastric mucosal injury in experimental animals and in humans. A decrease in the gastric mucosal blood flow also plays an important role in the aetiology of acute gastric mucosal injury, as we previously reported. This study investigated the effect of a newly synthesized NSAID, loxoprofen sodium (sodium 2[p-2 oxocyclopentylmethyl) phenyl]propionate dihydrate, on gastric mucosal haemodynamics using a reflectance spectrophotometry system. Both single and cross-over methods were used in five volunteer subjects. Loxoprofen sodium 60 mg (one tablet) or indomethacin 25 mg (one tablet), was diluted in 10 mL water at 25°C and sprayed on the gastric mucosa via a polyethylene tube inserted into the biopsy channel of an endoscope. After drug administration, reflectance spectra were taken every 5 min for 30 min. The indices of mucosal haemoglobin content (IHb) and oxygen saturation of haemoglobin (ISO2 ) were determined by the method previously reported by the authors. Indomethacin administration produced a significant decrease in both IHb and ISO2 values, indication ischaemia. Loxoprofen sodium, however, showed no significant differences in either of the parameters. Haemorrhagic erosions were evident after indomethacin administration, but none were found after loxoprofen sodium administration. The conclusion reached on the basis of this evidence is that one-time topical application of loxoprofen sodium is safer than indomethacin. 相似文献
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TAKAI SHIN-ICHIRO; OGIHARA TOSHIO; MORIMOTO SHIGETO; MIYAUCHI AKIRA; UMAHARA YUICHIK; MIYAUCHI FUMIO; TAKAMATSU JUNTA; KONISHI SHINGO 《Japanese journal of clinical oncology》1980,10(2):297-300
A 41-year-old female with sporadic medullary thyroid carcinoma(MTC) had a sensorimotor polyneuropathy manifested by progressivenumbness and muscle weakness in all of her extremities. Therewas marked improvement in the neurological disorder followingremoval of the MTC. Her endocrine and neurological findingsand the possible relationship between MTC and polyneuropathyare discussed. 相似文献
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SHINSAKU IMASHUKU SHIGEYOSHI HIBI SHINGO MORINAGA KAZUTAKA TAKAGI JIMING CHEN HIDEO MUGISHIMA TAKEFUMI ISHII MASAHIRO SAKO HIROKAZU ARAKAWA & MASAHIKO KATO 《British journal of haematology》1997,96(4):708-714
Five paediatric cases of haemophagocytic lymphohistiocytosis (HLH) which showed proliferation of granular atypical lymphocytoid cells in bone marrow are reported. All cases were girls aged 8 months to 4 years who had marked hepatosplenomegaly. Marker analysis on peripheral blood mononuclear cells revealed an increase in the CD3+ HLADR+ subset in three cases and the CD3− CD56+ subset in one case. An Epstein-Barr virus genome was detected in three cases, and monoclonality was confirmed in two cases. A characteristic morphology of large granular lymphocytes (LGL) was identified, with elongated bizarre features that resembled horsetail-, tadpole-, cucumber- or shooting star-type configurations on the bone marrow smear. Serum concentrations of soluble interleukin-2 receptor and interferon-gamma were elevated in all cases. All five cases required multi-agent chemotherapy which resulted in two complete remissions, two partial remissions and one no response. Refinement of treatment is required for these paediatric GLPD cases which probably comprise a specific high-risk subgroup among secondary HLH patients which had previously escaped notice. 相似文献
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KOJI NISHIZAWA NORIYUKI ITO SHINGO YAMAMOTO TOSHIYUKI KAMOTO OSAMU OGAWA 《International journal of urology》2006,13(5):619-621
A 44-year-old woman developed chylous ascites following laparoscopic transperitoneal left radical nephrectomy with para-aortic lymph node dissection. Because conservative managements failed to stop the lymphatic leakage, laparoscopic lymphostasis was performed. Drinking milk 6 h prior to the operation enabled visualization of chylous ascites. Although a definite fistula was hard to identify, most of the chylous leak disappeared after ligation of the para-aortic tissues at the distal and proximal ends of the previous lymph node dissection. Laparoscopic ligation of the para-aortic bundle of lymph ducts was effective in managing long-standing postoperative chylous ascites. 相似文献
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KEN KIMURA KENICHI IDO YUSHI TANIGUCHI TSUTOMU SUZUKI YUKIO YOSHIDA SUNAO KAWANO SHINGO TSUJI 《Journal of gastroenterology and hepatology》1996,11(10):916-921
Abstract At present, the evaluation of anti-ulcer drugs is generally accomplished simply by calculating the cumulative healing rate at a certain point of time during treatment, which does not implicate any analysis of the healing speed of the ulcer. If the cumulative healing rate of an ulcer is expressed as a function of drug administration time, t, then it will be possible to calculate parameters concerning the healing speed of ulcers and thus evaluate drug efficacy as the time series analysis of the cumulative healing rate. A new method of evaluating anti-ulcer drugs by a statistical analysis of healing speed is proposed. A non-linear regression analysis was performed between two variables, t (time of drug administration: week) and y (non-healing rate: %), to obtain the exponential function y = Ae?kt. The theoretical values calculated from the exponential equation were in close proximity to the observed values. With this analysis, four parameters concerning the healing speed were defined, namely the healing rate constant, the initiation time of healing, the half-life of non-healing rate and the time necessary for 50% healing. With this method, the efficacy of drugs on peptic ulcer healing was dynamically analysed, the non-healing rate (y) being expressed as an exponential function of length of time (t) of treatment, thus obtaining digital parameters for healing speed. 相似文献
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KEI NEGISHI MD NOBUHARU KUSHIKATA MD KAORI TAKEUCHI MD YUKIKO TEZUKA MD SHINGO WAKAMATSU MD 《Dermatologic surgery》2006,32(11):1380-1387
BACKGROUND AND OBJECTIVES: This study had two objectives: subjective evaluation of overall skin rejuvenation effects of relatively short-wavelength intense pulsed light (IPL) and objective changes in basic skin tone as measured by a spectrophotometer. STUDY DESIGN/MATERIALS AND METHODS: Twenty-five women selected at random received a series of three IPL treatments. Efficacy was evaluated over a 3-month follow-up period. Concurrently, a spectrophotometer was used to measure "lightness" (L(*)) to quantify the lightening effect changes to pretreatment and posttreatment basic skin tone. RESULTS: Subjective improvement of 50% or more was seen in 18 of 25 patients for pigmentation. One patient showed exacerbation of latent epidermal melasma as a complication. In the spectrophotometric analysis, the mean value of L(*) increased from a baseline value of 60.86 to 63.22, at 3-month follow-up period, with statistical significance. CONCLUSION: IPL skin rejuvenation using relatively shorter wavelengths and pulse widths brought about significant macroscopic and quantitative improvements, especially in the treatment of epidermal pigmentation and improvement of basic skin tone. 相似文献
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MITSUHIRO TANIGUCHI SHINGO KAMEI TOSHIMI TAKEUCHI SYUNSUKE SAKAI TAKASHI DEGUCHI 《International journal of urology》2005,12(3):313-315
Abstract A patient with lower pole moiety ureteropelvic junction obstruction in a partially duplicated collecting system was managed successfully by retrograde endoureteropyelotomy using a Holmium:YAG laser. To our knowledge, we report the first case of this entity managed successfully by retrograde endoureteropyelotomy without a percutaneous approach. 相似文献
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Relationship between interleukin-8 levels and myeloperoxidase activity in human gastric mucosa 总被引:10,自引:0,他引:10
YOSHIAKI SASAYAMA SUNAO KAWANO SHINGO TSUJI HIDEYUKI FUSAMOTO TAKENOBU KAMADA HIROYUKI FUKUI SHOTARO YONEDA TATSUO OKISHIO 《Journal of gastroenterology and hepatology》1997,12(2):104-108
Although interleukin (IL)-8 is well known as a chemotactic agent for neutrophil migration in vitro, the relationship between IL-8 activity and the degree of neutrophil infiltration in gastric mucosa is still unclear. In the present study, we investigated IL-8 and myeloperoxidase activity, a marker of neutrophil infiltration, in gastric antral mucosa using biopsy samples in 23 patients with no gastric lesions. The results indicate that there is a good correlation between IL-8 and myeloperoxidase activity (y = 0.173x + 13.9; r = 0.49, P<0.01). Furthermore, IL-8 and myeloperoxidase activity are significantly higher in Helicobacter pylori-positive patients than in H. pylori-negative patients. In conclusion, an increase of IL-8 activity in the gastric mucosa causes increased neutrophil infiltration in human gastric mucosa and H. pylori infection acclerates these reactions in the mucosa. 相似文献