全文获取类型
收费全文 | 2851799篇 |
免费 | 211151篇 |
国内免费 | 7146篇 |
专业分类
耳鼻咽喉 | 37936篇 |
儿科学 | 92620篇 |
妇产科学 | 78263篇 |
基础医学 | 404778篇 |
口腔科学 | 80238篇 |
临床医学 | 259100篇 |
内科学 | 557850篇 |
皮肤病学 | 66137篇 |
神经病学 | 226480篇 |
特种医学 | 108789篇 |
外国民族医学 | 696篇 |
外科学 | 426595篇 |
综合类 | 65271篇 |
现状与发展 | 12篇 |
一般理论 | 1008篇 |
预防医学 | 216836篇 |
眼科学 | 67270篇 |
药学 | 207877篇 |
7篇 | |
中国医学 | 7969篇 |
肿瘤学 | 164364篇 |
出版年
2021年 | 24889篇 |
2019年 | 24812篇 |
2018年 | 34919篇 |
2017年 | 26371篇 |
2016年 | 29986篇 |
2015年 | 34717篇 |
2014年 | 47629篇 |
2013年 | 69117篇 |
2012年 | 95639篇 |
2011年 | 100370篇 |
2010年 | 59301篇 |
2009年 | 55228篇 |
2008年 | 90969篇 |
2007年 | 95979篇 |
2006年 | 96133篇 |
2005年 | 92517篇 |
2004年 | 88410篇 |
2003年 | 83786篇 |
2002年 | 80352篇 |
2001年 | 139873篇 |
2000年 | 143267篇 |
1999年 | 118764篇 |
1998年 | 33124篇 |
1997年 | 29102篇 |
1996年 | 29142篇 |
1995年 | 27868篇 |
1994年 | 25393篇 |
1993年 | 23593篇 |
1992年 | 90281篇 |
1991年 | 86711篇 |
1990年 | 83377篇 |
1989年 | 80031篇 |
1988年 | 73283篇 |
1987年 | 71579篇 |
1986年 | 67119篇 |
1985年 | 63900篇 |
1984年 | 47714篇 |
1983年 | 40396篇 |
1982年 | 23608篇 |
1979年 | 42051篇 |
1978年 | 29328篇 |
1977年 | 24698篇 |
1976年 | 23213篇 |
1975年 | 24129篇 |
1974年 | 29198篇 |
1973年 | 28151篇 |
1972年 | 26226篇 |
1971年 | 24022篇 |
1970年 | 22646篇 |
1969年 | 21126篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
41.
Amy Y. Zhang Christopher Burant Alex Z. Fu Gerald Strauss Donald R. Bodner Lee Ponsky 《Journal of psychosocial oncology》2020,38(2):210-227
AbstractPurpose: We examined underlying psychosocial processes of a behavioral treatment for urinary incontinence (UI) of prostate cancer survivors.Design: Secondary analysis of data collected from a clinical trial.Sample: Two hundred forty-four prostate cancer survivors who participated in a clinical trial of behavioral intervention to UI as intervention or control subjects.Methods: The participants had a 3-month behavioral intervention or usual care and were followed up for an additional 3?months. They were assessed at baseline, 3, and 6?months. Latent growth curve models were performed to examine trajectories of each study variable and relationships among the variables.Findings: Increasing self-efficacy and social support were significantly and independently associated with more reduction of urinary leakage frequency over time.Implications for psychosocial oncology: Providing problem-solving skills and social support, including peer support, are essential for empowering patients to reduce UI. 相似文献
42.
43.
Béla Nagy Zsolt Bene Zsolt Fejes Sonya L. Heltshe David Reid Nicola J. Ronan Yvonne McCarthy Daniel Smith Attila Nagy Elizabeth Joseloff György Balla János Kappelmayer Milan Macek Scott C. Bell Barry J. Plant Margarida D. Amaral István Balogh 《Journal of cystic fibrosis》2019,18(2):271-277
Background
We have recently shown that human epididymis protein 4 (HE4) levels correlate with the severity of cystic fibrosis (CF) lung disease. However, there are no data on how HE4 levels alter in patients receiving CFTR modulating therapy.Methods
In this retrospective clinical study, 3 independent CF patient cohorts (US-American: 29, Australian: 12 and Irish: 19 cases) were enrolled carrying at least one Class III CFTR CF-causing mutation (p.Gly551Asp) and being treated with CFTR potentiator ivacaftor. Plasma HE4 was measured by immunoassay before treatment (baseline) and 1–6?months after commencement of ivacaftor, and were correlated with FEV1 (% predicted), sweat chloride, C-reactive protein (CRP) and body mass index (BMI).Results
After 1?month of therapy, HE4 levels were significantly lower than at baseline and remained decreased up to 6?months. A significant inverse correlation between absolute and delta values of HE4 and FEV1 (r?=??0.5376; P?<?.001 and r?=??0.3285; P?<?.001), was retrospectively observed in pooled groups, including an independent association of HE4 with FEV1 by multiple regression analysis (β?=??0.57, P?=?.019). Substantial area under the receiver operating characteristic curve (ROC-AUC) value was determined for HE4 when 7% mean change of FEV1 (0.722 [95% CI 0.581–0.863]; P?=?.029) were used as classifier, especially in the first 2?months of treatment (0.806 [95% CI 0.665–0.947]; P?<?.001).Conclusions
This study shows that plasma HE4 levels inversely correlate with lung function improvement in CF patients receiving ivacaftor. Overall, this potential biomarker may be of value for routine clinical and laboratory follow-up of CFTR modulating therapy. 相似文献44.
T. Kapellen A. Galler K. Claus S. Heger D. Härtig Prof. Dr. W. Kiess 《Der Diabetologe》2006,2(2):167-181
Type 1 diabetes is one of the commonest chronic disorders encountered in children and adolescents. When it first becomes apparent in children, approximately 20% of them have clinical and biochemical signs of ketoacidosis (DKA). In the presence of unusual clinical symptoms it is necessary to consider the possibility of associated conditions, such as coeliac disease, immunothyroiditis and Addison’s disease. Children with diabetes must be treated by a multidisciplinary team made up of paediatrician, paediatric diabetes specialist, psychologist, social worker, ophthalmologist, dietitian, nurse and diabetes counsellor, making it essential for them to be treated in regional specialised centres. They are treated in their own psychosocial environment and their families are involved in the therapy. Comprehensive, multidisciplinary treatment strategies have now made it possible for these patients to enjoy normal physical wellbeing and near-normal psychosocial development. Prevention and early treatment of of disturbances associated with diabetes remain an important concern. The fact that type 2 diabetes must now be looked for in overweight children and adolescents is a new aspect of diabetes medicine. 相似文献
45.
Chronic transplant dysfunction is a complex dynamic pathogenic process. Clinically, a decrease in glomerular filtration rate (GFR) becomes apparent leading to chronic renal insufficiency and dialysis or death from cardiovascular events. Chronic transplant dysfunction can develop into a chronic alIograft nephropathy (CAN) as a specific entity with dynamic progression. CAN includes a collection of immunologic and non-immunologic factors, rejection, ischemia time, donor and recipient characteristics and toxicity of calcineurin inhibitors. Despite improvements in immunosuppression, the long-range prognosis of renal allografts has not improved. Whether modern immunosuppressive concepts with reduction or avoidance of calcineurin inhibitors and a therapy based on antimetabolites, such as mycophenolate or mTOR-inhibitors could lead to a prolongation of transplant survival, remains to be seen. 相似文献
46.
Thomas S. Klitzner Maggie Lee Sandra Rodriguez Ruey‐Kang R. Chang 《Congenital heart disease》2006,1(3):77-88
Background. It has been reported that gender differences in cardiovascular outcomes found in adults also are present in children who undergo surgical repair for congenital heart disease. Methods. California statewide hospital discharge data 1989–99 were used to study outcomes in children <18 years undergoing cardiac surgery. Hospital discharge data were linked to death registry data to study postdischarge death within 30 days of discharge. We used logistic regression to evaluate the effect of gender on mortality controlling for age, race and ethnicity, type of insurance, household income, date and month of surgery, type of admission, hospital case volume, and various types of procedures. Results. There were 25 402 cardiac surgery cases with 1505 in‐hospital deaths (mortality rate of 5.92%). An additional 37 deaths occurred within 30 days after hospital discharge. Crude mortality rates for males (5.99%) and females (5.84%) were not significantly different. However, fewer neonates were female and females underwent a higher proportion of low‐risk procedures than males. Logistic regression revealed that females, compared with males, had a significantly higher odds ratio (OR) for in‐hospital mortality (OR = 1.18, P < .01) and overall (up to 30 days post discharge) mortality (OR = 1.18, P < .01). The risk‐adjusted length of hospital stay was similar between females and males while charges per hospital day were slightly higher in females than males. The prevalence of Down syndrome, pulmonary hypertension, and failure to thrive were higher in females. Conclusions. Female gender is associated with an 18% higher in‐hospital and 30‐day postdischarge mortality as compared with male gender. There was no difference in length of hospital stay between males and females. The mechanism by which female gender acts as a risk factor requires further investigation. 相似文献
47.
48.
49.
50.
It is often difficult for medical professionals to understand the behaviour of people with diabetic foot syndrome. We describe the different psychological factors that play a role in the maintenance of intermittent implementation of medical recommendations. In particular we look at the consequences of neuropathy and of the recommendation to offload pressure, as well as the contradictions between the realities of the patient and the medical professionals involved in their care. We show that the solutions that patients develop are based on normal psychological processes and we encourage professionals to consider these aspects in their relationship to people with DFS and when developing individualised preventative measures. 相似文献