全文获取类型
收费全文 | 2124篇 |
免费 | 164篇 |
国内免费 | 24篇 |
专业分类
耳鼻咽喉 | 30篇 |
儿科学 | 45篇 |
妇产科学 | 6篇 |
基础医学 | 258篇 |
口腔科学 | 53篇 |
临床医学 | 169篇 |
内科学 | 511篇 |
皮肤病学 | 68篇 |
神经病学 | 253篇 |
特种医学 | 102篇 |
外科学 | 402篇 |
综合类 | 12篇 |
预防医学 | 46篇 |
眼科学 | 26篇 |
药学 | 114篇 |
中国医学 | 1篇 |
肿瘤学 | 216篇 |
出版年
2023年 | 52篇 |
2022年 | 89篇 |
2021年 | 144篇 |
2020年 | 61篇 |
2019年 | 103篇 |
2018年 | 90篇 |
2017年 | 80篇 |
2016年 | 81篇 |
2015年 | 113篇 |
2014年 | 123篇 |
2013年 | 111篇 |
2012年 | 170篇 |
2011年 | 169篇 |
2010年 | 104篇 |
2009年 | 84篇 |
2008年 | 120篇 |
2007年 | 115篇 |
2006年 | 95篇 |
2005年 | 78篇 |
2004年 | 73篇 |
2003年 | 78篇 |
2002年 | 62篇 |
2001年 | 7篇 |
2000年 | 7篇 |
1999年 | 8篇 |
1998年 | 14篇 |
1997年 | 8篇 |
1996年 | 8篇 |
1995年 | 5篇 |
1994年 | 4篇 |
1993年 | 6篇 |
1992年 | 8篇 |
1991年 | 4篇 |
1990年 | 4篇 |
1989年 | 4篇 |
1987年 | 8篇 |
1986年 | 2篇 |
1985年 | 1篇 |
1983年 | 2篇 |
1982年 | 4篇 |
1981年 | 2篇 |
1980年 | 1篇 |
1979年 | 1篇 |
1977年 | 1篇 |
1975年 | 1篇 |
1974年 | 1篇 |
1973年 | 1篇 |
1967年 | 1篇 |
1965年 | 1篇 |
1963年 | 1篇 |
排序方式: 共有2312条查询结果,搜索用时 15 毫秒
61.
Yoshinao Asahi Ryosuke Fujii Naoko Usui Hajime Kagamiuchi Shiro Omichi Junichiro Kotani 《Anesthesia progress》2015,62(2):71-73
Noonan syndrome (NS) is an autosomal dominant disorder characterized by facial anomalies, short stature, chest deformity, congenital heart diseases, and other comorbidities. The challenges faced during anesthetic management of patients with NS could be due to congenital heart diseases, hemostatic disorders, and airway anomalies. Here we describe dental treatment under general anesthesia performed for a 28-year-old man with NS. He had characteristic features of NS along with mild pulmonary valve stenosis. Dental treatment under general anesthesia was performed successfully on 13 occasions with nasotracheal intubation under curve-tipped suction catheter guidance or insertion of a reinforced laryngeal mask airway. This case suggests that for patients with NS, who might present several challenges, dental anesthesiologists should consider the extent of the patient''s disorders to enable them to perform dental treatment safely under general anesthesia.Key Words: Repeated general anesthesia, Noonan syndromeNoonan syndrome (NS) is an autosomal dominant disorder and was first reported by Noonan and Ehmke.1 The primary features of this multisystem disorder include hypertelorism, low-set ears, down-slanting eyes, a webbed neck, congenital heart diseases, short stature, chest deformity, and intellectual impairment.2,3 NS affects males and females equally and has an estimated incidence of 1 in 1000 to 1 in 2500 live births.2,4The challenges faced during anesthetic management of patients with NS could be due to congenital heart diseases, hemostatic disorders, and airway anomalies.5–8 The present report describes repeated administration of general anesthesia performed by adopting nasotracheal intubation or reinforced laryngeal mask airway insertion for a patient with NS at the time of dental treatment in our hospital. 相似文献
62.
Influence of E. coli‐induced prostatic inflammation on expression of androgen‐responsive genes and transforming growth factor beta 1 cascade genes in rats
下载免费PDF全文
![点击此处可从《The Prostate》网站下载免费的PDF全文](/ch/ext_images/free.gif)
63.
Legg‐Calvé‐Perthes Disease Produces Chronic Hip Synovitis and Elevation of Interleukin‐6 in the Synovial Fluid
下载免费PDF全文
![点击此处可从《Journal of bone and mineral research》网站下载免费的PDF全文](/ch/ext_images/free.gif)
Nobuhiro Kamiya Ryosuke Yamaguchi Naga Suresh Adapala Elena Chen David Neal Obrien Jack Alec Thoveson Paul Gudmundsson Case Brabham Olumide Aruwajoye Hicham Drissi Harry KW Kim 《Journal of bone and mineral research》2015,30(6):1009-1013
Legg‐Calvé‐Perthes disease (LCPD) is a childhood hip disorder of ischemic osteonecrosis of the femoral head. Hip joint synovitis is a common feature of LCPD, but the nature and pathophysiology of the synovitis remain unknown. The purpose of this study was to determine the chronicity of the synovitis and the inflammatory cytokines present in the synovial fluid at an active stage of LCPD. Serial MRI was performed on 28 patients. T2‐weighted and gadolinium‐enhanced MR images were used to assess synovial effusion and synovial enhancement (hyperemia) over time. A multiple‐cytokine assay was used to determine the levels of 27 inflammatory cytokines and related factors present in the synovial fluid from 13 patients. MRI analysis showed fold increases of 5.0 ± 3.3 and 3.1 ± 2.1 in the synovial fluid volume in the affected hip compared to the unaffected hip at the initial and the last follow‐up MRI, respectively. The mean duration between the initial and the last MRI was 17.7 ± 8.3 months. The volume of enhanced synovium on the contrast MRI was increased 16.5 ± 8.5 fold and 6.3 ± 5.6 fold in the affected hip compared to the unaffected hip at the initial MRI and the last follow‐up MRI, respectively. In the synovial fluid of the affected hips, IL‐6 protein levels were significantly increased (LCPD: 509 ± 519 pg/mL, non‐LCPD: 19 ± 22 pg/mL; p = 0.0005) on the multi‐cytokine assay. Interestingly, IL‐1β and TNF‐α levels were not elevated. In the active stage of LCPD, chronic hip synovitis and significant elevation of IL‐6 are produced in the synovial fluid. Further studies are warranted to investigate the role of IL‐6 on the pathophysiology of synovitis in LCPD and how it affects bone healing. © 2015 American Society for Bone and Mineral Research 相似文献
64.
Non‐inferiority of silodosin 4 mg once daily to twice daily for storage symptoms score evaluated by the International Prostate Symptom Score in Japanese patients with benign prostatic hyperplasia: A multicenter,randomized, parallel‐group study
下载免费PDF全文
![点击此处可从《International journal of urology》网站下载免费的PDF全文](/ch/ext_images/free.gif)
65.
MicroRNA‐205 inhibits cancer cell migration and invasion via modulation of centromere protein F regulating pathways in prostate cancer
下载免费PDF全文
![点击此处可从《International journal of urology》网站下载免费的PDF全文](/ch/ext_images/free.gif)
66.
67.
A randomized controlled trial of radiofrequency ablation with ethanol injection for small hepatocellular carcinoma 总被引:35,自引:0,他引:35
Shiina S Teratani T Obi S Sato S Tateishi R Fujishima T Ishikawa T Koike Y Yoshida H Kawabe T Omata M 《Gastroenterology》2005,129(1):122-130
BACKGROUND & AIMS: Percutaneous radiofrequency ablation is a recently introduced treatment for hepatocellular carcinoma, whereas ethanol injection is now a standard therapy. We compared their long-term outcomes. METHODS: Two hundred thirty-two patients with hepatocellular carcinoma who had 3 or fewer lesions, each 3 cm or less in diameter, and liver function of Child-Pugh class A or B were entered onto a randomized controlled trial. The primary end point was survival, and the secondary end points were overall recurrence and local tumor progression. RESULTS: One hundred eighteen patients were assigned to radiofrequency ablation and 114 to ethanol injection. The number of treatment sessions was smaller (2.1 times vs 6.4 times, respectively, P < .0001) and the length of hospitalization was shorter (10.8 days vs 26.1 days, respectively, P < .0001) in radiofrequency ablation than in ethanol injection. Four-year survival rate was 74% (95% CI: 65%-84%) in radiofrequency ablation and 57% (95% CI: 45%-71%) in ethanol injection. Radiofrequency ablation had a 46% smaller risk of death (adjusted relative risk, 0.54 [95% CI: 0.33-0.89], P = .02), a 43% smaller risk of overall recurrence (adjusted relative risk 0.57 [95% CI: 0.41-0.80], P = .0009), and an 88% smaller risk of local tumor progression (relative risk, 0.12 [95% CI: 0.03-0.55], P = .006) than ethanol injection. The incidence of adverse events was not different between the 2 therapies. CONCLUSIONS: Judging from higher survival but similar adverse events, radiofrequency ablation is superior to ethanol injection for small hepatocellular carcinoma. 相似文献
68.
Harutoshi Asakawa Gen Sazaki Ken Nagashima Shunichi Nakatsubo Yoshinori Furukawa 《Proceedings of the National Academy of Sciences of the United States of America》2016,113(7):1749-1753
Surfaces of ice are covered with thin liquid water layers, called quasi-liquid layers (QLLs), even below their melting point (0 °C), which govern a wide variety of phenomena in nature. We recently found that two types of QLL phases appear that exhibit different morphologies (droplets and thin layers) [Sazaki G. et al. (2012) Proc Natl Acad Sci USA 109(4):1052−1055]. However, revealing the thermodynamic stabilities of QLLs remains a longstanding elusive problem. Here we show that both types of QLLs are metastable phases that appear only if the water vapor pressure is higher than a certain critical supersaturation. We directly visualized the QLLs on ice crystal surfaces by advanced optical microscopy, which can detect 0.37-nm-thick elementary steps on ice crystal surfaces. At a certain fixed temperature, as the water vapor pressure decreased, thin-layer QLLs first disappeared, and then droplet QLLs vanished next, although elementary steps of ice crystals were still growing. These results clearly demonstrate that both types of QLLs are kinetically formed, not by the melting of ice surfaces, but by the deposition of supersaturated water vapor on ice surfaces. To our knowledge, this is the first experimental evidence that supersaturation of water vapor plays a crucially important role in the formation of QLLs.Ice is one of the most abundant materials on Earth, and its surfaces are covered with thin liquid water layers even below their melting point (0 °C) (1–4). Such thin liquid water layers are called “quasi-liquid layers” (QLLs). Because QLLs govern the surface properties of ice just below the melting point, it is well acknowledged that surface melting of ice governs a wide variety of phenomena, such as electrification of thunderclouds (4, 5), regelation (4, 6), frost heave (4, 7), conservation of foods, ice skating (1, 8), preparation of a snowman (1), and growth of ice crystals (2, 4). Therefore, it is essential to understand the surface melting of ice crystals at the molecular level.After Michael Faraday proposed the existence of QLLs in 1842 (1), many studies experimentally confirmed the formation of QLLs by various methods (Measurement method Reference First author (experimental condition) Proton channeling (24, 25) G (S) Proton backscattering (26, 27) F (U) Ellipsometry (23, 28) F (U), B (E) X-ray diffraction (29) K (E) Glancing-angle X-ray scattering (30, 31) D (U) Quasi-elastic neutron scattering (32) M (E) Photoelectron spectroscopy (33, 34) N (E), B (E) NMR (35, 36) K (E), M (U) Optical microscopy (37, 38) E (S), G (S) Optical displacement sensor (39) K (U) Infrared spectroscopy (40) S (S) Sum-frequency vibrational spectroscopy (41, 42) W (E) Atomic force microscopy (43–46) B (S), D (U), S (U, E, S), P (E)