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21.
Sustained virologic response achieved after curative treatment of hepatitis C virus‐related hepatocellular carcinoma as an independent prognostic factor
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Naoya Kanogawa Sadahisa Ogasawara Tetsuhiro Chiba Tomoko Saito Tenyu Motoyama Eiichiro Suzuki Yoshihiko Ooka Akinobu Tawada Tatsuo Kanda Shigeru Mikami Ryosaku Azemoto Takashi Kaiho Masami Shinozaki Masayuki Ohtsuka Masaru Miyazaki Osamu Yokosuka 《Journal of gastroenterology and hepatology》2015,30(7):1197-1204
22.
Takashi Terao Teru Kumagi Ichinosuke Hyodo Tomoyuki Yokota Nobuaki Azemoto Hideki Miyata Taira Kuroda Yoshinori Ohno Yoshinori Tanaka Naozumi Shibata Yoshiki Imamura Kozue Kanemitsu Teruki Miyake Mitsuhito Koizumi Yoichi Hiasa 《Medicine》2021,100(43)
Most patients with pancreatic cancer are ineligible for curative resection at diagnosis, resulting in poor prognosis. This study aimed to evaluate the prognostic factors in patients with unresectable pancreatic cancer.We retrospectively collected clinical data from 196 patients with unresectable pancreatic cancer who received palliative chemotherapy (N = 153) or palliative care alone (N = 43) from January 2011 to December 2013. Patients’ background data and overall survival were analyzed using the Cox proportional hazard regression model.In patients receiving palliative chemotherapy (gemcitabine-based regimen, 88.2%) and palliative care alone, the median (range) ages were 68 (43–91) and 78 (53–90) years, and metastatic diseases were present in 80% (N = 123) and 86% (N = 37), respectively. Multivariate analysis in the palliative chemotherapy patients showed that liver metastasis (hazard ratio [HR] 2.25, 95% confidence interval [CI] 1.58–3.20, P < .001), neutrophil-to-lymphocyte ratio (>4.5 vs ≤4.5; HR 3.45, 95% CI 2.22–5.36, P < .001), and cancer antigen 19-9 (CA19-9) (≥900 vs <900 U/mL; HR 1.45, 95% CI 1.02–2.05, P = .036) were independent prognostic factors. In those receiving palliative care alone, lung (HR 3.27, 95% Cl 1.46-7.35, p = 0.004) and peritoneum (HR 2.50, 95% CI 1.20–5.18, P = .014) metastases and the C-reactive protein-to-albumin ratio (≥1.3 vs <1.3; HR 3.33, 95% Cl 1.51–7.35, P = .003) were independent prognostic factors. Furthermore, patients with multiple factors had worse prognosis in both groups. Median survival time of palliative chemotherapy patients with risk factors 0, 1, 2, and 3 were 13.1 (95% CI 8.0–16.9), 9.4 (95% CI 7.9–10.1), 6.6 (95% CI 4.9–7.8), and 2.5 (95% CI 1.7–4.0) months, respectively. Similarly, median survival time was 5.7 (95% CI 1.3 -8.0), 2.1 (95% CI 1.5–3.9), and 1.3 (95% CI 0.6–1.7) months, respectively, for palliative care alone patients with risk factor 0, 1, and 2 to 3.Prognostic markers for pancreatic cancer were neutrophil-to-lymphocyte ratio, liver metastasis, and CA19-9 in patients undergoing palliative chemotherapy and C-reactive protein-to-albumin ratio and lung/peritoneum metastases in patients undergoing palliative care alone. These simple markers should be considered when explaining the prognosis and therapeutic options to patients. 相似文献
23.
Kentaro Sudo Takeshi Ishihara Nobuto Hirata Fumiaki Ozawa Tadashi Ohshima Ryosaku Azemoto Kenji Shimura Takeshi Nihei Takayoshi Nishino Akihiko Nakagawa Kazuyoshi Nakamura Taro Hara Motohisa Tada Rintaro Mikata Katsunobu Tawada Osamu Yokosuka So Nakaji Taketo Yamaguchi 《Cancer chemotherapy and pharmacology》2014,73(2):389-396
Purpose
The aim of this study was to evaluate efficacy and safety of gemcitabine plus S-1 (GS) combination chemotherapy in patients with unresectable pancreatic cancer.Methods
Patients were randomly assigned to receive GS (oral S-1 60 mg/m2 daily on days 1–15 every 3 weeks and gemcitabine 1,000 mg/m2 on days 8 and 15) or gemcitabine (1,000 mg/m2 on days 1, 8, and 15 every 4 weeks). The primary endpoint was progression-free survival (PFS).Results
One hundred and one patients were randomly assigned. PFS was significantly longer in the GS arm with an estimated hazard ratio (HR) of 0.65 (95 % CI 0.43–0.98; P = 0.039; median 5.3 vs 3.8 months). Objective response rate (ORR) was also better in the GS arm (21.6 vs 6 %, P = 0.048). Median survival was 8.6 months for GS and 8.6 months for GEM (HR 0.93; 95 % CI 0.61–1.41; P = 0.714). Grade 3–4 neutropenia (44 vs 19.6 %, P = 0.011) and thrombocytopenia (26 vs 8.7 %, P = 0.051) were more frequent in the GS arm.Conclusions
GS therapy improved PFS and ORR with acceptable toxicity profile in patients with unresectable pancreatic cancer. 相似文献24.
Yamada Masayoshi Shino Ryosaku Kondo Hiroko Yamada Shigemi Takamaru Hiroyuki Sakamoto Taku Bhandari Pradeep Imaoka Hitoshi Kuchiba Aya Shibata Taro Saito Yutaka Hamamoto Ryuji 《Journal of gastroenterology》2022,57(11):879-889
Journal of Gastroenterology - Improved optical diagnostic technology is needed that can be used by also outside expert centers. Hence, we developed an artificial intelligence (AI) system that... 相似文献
25.
Sunagawa T Kinjo F Gakiya I Hokama A Kugai Y Matayoshi R Yonamine Y Tomiyama R Saito A 《Internal medicine (Tokyo, Japan)》2004,43(5):397-399
Protein-losing gastroenteropathy (PLG) can occur as a manifestation of various diseases including autoimmune disorders, and optimal therapy of these underlying diseases may be the only effective remedy for PLG. In the present report, we describe a case of a 54-year-old woman with PLG associated with an autoimmune disease, presumably CREST syndrome. She failed to respond to steroid treatment. Subsequently, cyclosporine was initiated, which resulted in a rapid recovery. The patient was successfully treated with low-dose cyclosporine for five years. There has not been, to our knowledge, any report of PLG successfully treated with cyclosporine. Cyclosporine therapy may be effective not only in inducing but also in maintaining complete remission in patients with autoimmune-associated PLG, especially refractory or intolerable to steroids and/or immunosuppressive therapies. 相似文献
26.
Hirofumi Yamanishi Tomoyuki Yokota Nobuaki Azemoto Masashi Hirooka Hidehiro Murakami Yoichi Hiasa Bunzo Matsuura Morikazu Onji 《Clinical journal of gastroenterology》2009,2(3):232-237
An asymptomatic 66-year-old woman was admitted to our hospital for detailed evaluation of a 63-mm mass in the tail of the
pancreas detected on abdominal computed tomography (CT). Abdominal ultrasound (US) revealed a hypoechoic solid mass, but on
contrast-enhanced ultrasound (CE-US) with perflubutane, a stellate structure within the tumor, characteristic of a serous
cystadenoma, was observed. A distal pancreatectomy was performed, and histologic examination confirmed a serous cystadenoma
of the pancreas. This case highlights the usefulness of CE-US with perflubutane for diagnosis of pancreatic serous cystadenomas. 相似文献
27.
Background One of the problems in prosthetic-valve recipients is the development of gallstones. We suggested that the use of a heart-lung machine may be closely related to gallstone formation. The objective of this study was to clarify the efficacy of ursodeoxycholic acid (UDCA) in the prevention of gallstone formation after open cardiac surgery.Methods One hundred and six patients without gallstones who underwent cardiac surgery in which a heart-lung machine was used were randomly divided into two groups: group A, comprising 54 patients who did not receive UDCA, and group B, comprising 52 patients who received UDCA (600mg daily for 6 months from 1 week before surgery). Both groups were followed by ultrasonography for 60 months. Blood markers of hemolysis (hemoglobin, reticulocyte count, haptoglobin, total bilirubin, and lactate dehydrogenase) were evaluated before, immediately after, and at 3 weeks and 3, 6, 12, 24, and 60 months after surgery.Results In groups A and B, cumulative incidence rates for gallstone formation were 15.1% and 0% at 3 months, 23.0% and 0% at 6 months, 29.2% and 2.0% at 12 months, 29.2% and 8.4% at 24 months, and 29.2% and 8.4% at 60 months, respectively. In regard to the composition of the gallstones, they were considered to be mainly black pigment stones.Conclusions The prophylactic administration of UDCA resulted in a significant decrease in the incidence of gallstones after open cardiac surgery. 相似文献
28.
29.
M Ogawa R Azemoto Y Makino Y Mori S Ueda M Wakashin M Ohto 《Journal of internal medicine》1991,229(2):189-192
We present the case of a 16-year-old woman with Wegener's granulomatosis, who developed a pneumothorax while receiving treatment with cyclophosphamide and glucocorticoids. The lung was re-expanded by tube drainage, and the patient recovered completely while the immunosuppressive treatment was continued in combination with sulphamethoxazole-trimethoprim. A possible role for this antimicrobial drug in the treatment of Wegener's granulomatosis is briefly discussed. 相似文献
30.