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排序方式: 共有5017条查询结果,搜索用时 31 毫秒
951.
Anne Marie Valente Kimberlee Gauvreau Gabriele Egidy Assenza Sonya V. Babu-Narayan Sarah P. Evans Michael Gatzoulis Maarten Groenink Ryo Inuzuka Philip J. Kilner Zeliha Koyak Michael J. Landzberg Barbara Mulder Andrew J. Powell Rachel Wald Tal Geva 《Pediatric cardiology》2013,34(1):95-104
Although early survival after tetralogy of Fallot (TOF) repair in the modern era is excellent, studies on late outcomes have shown increasing rates of mortality and morbidity. Despite multiple publications on factors associated with late complications, risk factors for major outcomes (death and sustained ventricular tachycardia [VT]) remain poorly defined. Consequently, the International Multicenter TOF Registry (INDICATOR) was established. This article describes the development, structure, and goals of this registry and characterizes the initial cohort derived from four large congenital heart centers in the United States, Canada, and Europe. A data coordinating center with a core cardiac magnetic resonance (CMR) laboratory and statistical core was established. Subjects with repaired TOF who had CMR imaging performed between 1997 and 2010 and ≥1 year follow-up were included. Clinical end points were death and sustained VT. Demographic, electrophysiologic, exercise, and outcome data were collected. A total of 873 subjects fulfilled inclusion criteria (median age at repair 2.9 years and at CMR imaging 22.8 years). Of these, 9 % had QRS duration >180 ms on electrocardiogram (ECG). On CMR imaging, 38 % had severe right-ventricular (RV) dilatation (≥160 mL/m2), and 6 % had severe RV dysfunction (ejection fraction < 35 %). Of the 551 subjects with exercise testing available, 28 % had severely decreased exercise capacity with <50 % predicted peak oxygen consumption. The INDICATOR cohort allows robust statistical analysis to evaluate major clinical outcomes in patients with repaired TOF. Continued follow-up and further expansion of the registry may provide new insights into innovative therapeutic strategies to improve late outcomes. 相似文献
952.
This report presents two rare cases of malpositioned pulmonary artery branches managed by bilateral banding. The left-branch pulmonary artery, originating from and directly superior to the right branch, entered the posterior mediastinum before heading toward the left pulmonary hilum. The ostium of the left branch could not be visualized by midline sternotomy. Therefore, a double-subtraction technique was used to pass the banding tape around the left branch from the right side. The tape location was adjusted and confirmed by intraoperative echocardiography. 相似文献
953.
954.
Gouji Toyokawa Mitsuhiro Takenoyama Kenichi Taguchi Katsumi Arakaki Eiko Inamasu Ryo Toyozawa Miyako Kojo Yoshimasa Shiraishi Yosuke Morodomi Tomoyoshi Takenaka Fumihiko Hirai Masafumi Yamaguchi Takashi Seto Alvaro Leone Paolo Graziano Yukito Ichinose 《Lung cancer (Amsterdam, Netherlands)》2013
Mutations of the epidermal growth factor receptor (EGFR) gene play a critical role in carcinogenesis of lung cancer, particularly adenocarcinoma. However, to the best of our knowledge, no mutations of the EGFR in patients with lung carcinosarcoma have been identified. We herein report the case of a 61-year-old female referred for a detailed examination of a left pulmonary mass shadow. Although bronchoscopy was performed, it failed to lead to a diagnosis, and video-assisted thoracoscopic surgery was therefore carried out to diagnose the tumor. The pathology revealed biphasic features consisting of both adenocarcinoma and chondrosarcoma. Intriguingly, both the adenocarcinoma and chondrosarcoma components were proven to harbor an exon19 deletion in the EGFR gene. Although carcinosarcoma is a rare malignancy of the lungs, genetic analyses of oncogenic drivers, such as the EGFR gene, should be conducted. 相似文献
955.
Tetsuo Nonaka Yuko Nakayama Nobutaka Mizoguchi Ryo Onose Hisamori Kato Hiroki Nakayama 《International journal of clinical oncology / Japan Society of Clinical Oncology》2013,18(2):314-320
Background
This study was designed to evaluate the efficacy of definitive radiation therapy (RT) for invasive carcinoma of the vagina.Methods
Twenty-six patients with invasive carcinoma of the vagina who received RT were studied retrospectively. The median age was 68 years. The pathologic subtype of vaginal carcinoma was squamous cell carcinoma in 24 patients, adenosquamous cell carcinoma in one patient, and adenocarcinoma in one patient. The distribution of clinical stage according to the International Federation of Gynecology and Obstetrics staging system was as follows: stage I, seven patients; stage II, 10 patients, stage III, seven patients; and stage IVA, two patients. Twenty patients received external beam radiation therapy (EBRT) combined with high-dose rate intracavitary brachytherapy (HDR-ICBT), and three received EBRT alone. The remaining three patients with stage I disease were given HDR-ICBT alone. The median dose was 50 Gy for EBRT, and 23 Gy for HDR-ICBT. Systemic chemotherapy was administered concurrently with RT to three patients.Results
The median follow-up was 90 months. The initial rate of response to RT was 100%, and complete remission was attained in 21 patients (81%). The 5-year overall survival rate (OS) and the median survival time of the 26 patients were 57% and 97 months, respectively. The 5-year OS for the three patients who received HDR-ICBT alone was 100%. Severe toxicity occurred in three patients—grade 3 rectal hemorrhage in one, grade 3 cystitis in one, and grade 4 cystitis in one.Conclusions
Our results demonstrated that definitive RT with HDR-ICBT is effective for invasive carcinoma of the vagina, with acceptable toxicity. 相似文献956.
Naoko Sanuki Atsuya Takeda Atsushi Amemiya Toru Ofuchi Masashi Ono Haruki Ogata Ryo Yamagami Jun Hatayama Takahisa Eriguchi Etsuo Kunieda 《Clinical breast cancer》2013,13(1):69-76
PurposeWe analyzed whether axillary nodal irradiation could control clinically node-negative disease, including those patients with a positive sentinel lymph node biopsy (SLNB), most of whom received regional nodal irradiation. We also evaluated toxicity profiles that resulted from nodal irradiation.Patients and MethodsFrom 1988 to 2011, 2107 patients with cT1-T2N0M0 breast cancer underwent breast conservation therapy in the absence of axillary dissection: nx group (n = 1548), without any axillary surgery; the sn? group (n = 518), with a negative SLNB; and sn+ group (n = 104), with a positive SLNB.ResultsThe median follow-up times were 88, 56, and 55 months for the nx, sn?, and sn+ groups, respectively. The nx group had more risk factors than did the other 2 groups in terms of age, grade, or T stage. Ninety-eight percent of the sn?group received only tangent irradiation, and 100% and 83% of the sn+ and nx group, respectively, received additional regional nodal irradiation. The 5-year cumulative incidences of axillary failure and regional nodal failure were 34, 3, and 0 (2.7%, 0.7%, and 0%; P = .02, log-rank test) and 57, 4, and 0 (4.4, 1%, and 0; P = .04), respectively. Overall survival rates in 5 years were 96.4%, 98.9%, and 97.6% (P = .03), respectively. Symptomatic but transient radiation pneumonitis developed in 31, 16, and 6 (2.0%, 3.1%, and 5.7%). Mild arm edema was observed in 1, 4, and 0 (0.06%, 0.8%, and 0%) in the nx, sn?, sn+ groups, respectively.ConclusionsTreatment without axillary dissection showed excellent outcomes with negligible toxicity for patients with clinically node negative, including those with a positive SLNB. Regional nodal irradiation after a positive SLNB is a reasonable alternative to axillary dissection. 相似文献
957.
Hinode D Fukui M Yokoyama N Yokoyama M Yoshioka M Nakamura R 《Journal of clinical periodontology》2003,30(12):1017-1023
AIM: The aim of this study was to confirm the relationships between oral malodor and periodontal condition, oral malodor and tongue coating, and to investigate the secretory-immunoglobulin A (S-IgA) level in saliva in relation to the accumulation of tongue coating. METHODS: Fifty-four patients complaining of oral malodor were included in the study. Their periodontal conditions, tongue coating status and salivary characteristics (flow rate, protein and S-IgA concentrations) were assessed in addition to the level of volatile sulfur compounds (VSC) in oral cavity. The patients were divided into three groups according to their tongue coating level. RESULTS: There are significant relationships between oral malodor and specific periodontal parameters used. The degree of tongue coating was also significantly correlated with the amount of H2S, CH3SH and the total amount of VSC determined. The concentration of S-IgA in the group identified as slight tongue coating was significantly higher than in the moderate or the severe group. By Western immunoblotting analysis, a high level of S-IgA specific to Streptococcus species was recognized in all groups, whereas the reactivity of Porphyromonas gingivalis and Fusobacterium nucleatum with S-IgA was very weak in both the slight and the moderate groups. CONCLUSION: Data herein indicate that tongue coating is closely related to oral malodor. Furthermore, S-IgA in saliva may influence the accumulation of tongue coating, and S-IgA antibodies directed to Streptococcus species may play a role in protective immunity against the initial colonization of tongue plaque. 相似文献
958.
Kazuhiro Nagata Satol Hori Ryo Mizuhashi Tomoko Yokoe Yojiro Atsumi Wataru Nagai Motoatu Goto 《Journal of prosthodontic research》2019,63(2):202-209
Purpose
Manual therapy has been used for the treatment of patients with temporomandibular disorders (TMD) with mouth-opening limitations. However, the curative effect of manipulation differs among researchers, and its necessity remains controversial. The purpose of this study was to confirm the efficacy of manipulation using a randomized controlled trial (RCT).Methods
A total of 61 TMD patients who had mouth-opening limitation (upper and lower middle incisor distance ≤35 mm) were selected. They were divided into two treatment groups: conventional treatment (n = 30) and conventional treatment plus manipulation (n = 31). The conventional treatment included two types of self-exercise: cognitive behavioral therapy for bruxism and education. Mouth-opening limitation, orofacial pain, and temporomandibular joint (TMJ) sounds were recorded from baseline to 18 weeks after baseline. These parameters were statistically compared between the two treatment groups by using analysis of variance (ANOVA) and Scheffe’s test to assess mouth opening distance and pain; TMJ sounds were compared using Mann–Whitney U test.Results
No statistical difference was observed between the two treatment groups except for mouth-opening limitation after treatment at the first visit. Subgroup analyses, stratified according to the pathological type of TMD, indicated a similar trend.Conclusions
The efficacy of manipulation seems to be limited, in contrast to our expectations, and improved execution of therapeutic exercises has a similar effect to that of manipulation during long-term observation. The advantage of manipulation was observed only during the first treatment session. The RCT was registered in the University Hospital Medical Information Network in Japan (UMIN-CTR: 000010437). 相似文献959.
Purpose
The purpose of this study was to examine the hypothesis that in the process from food ingestion to swallowing, intentional decrease in the muscle activity during mastication would affect the number of chewing strokes, and thus the occurrence of Stage II transport (St2Tr) or the number of swallowing.Methods
Twenty adults with healthy dentition were instructed to make (1) normal mastication and (2) mastication with 50% muscle activity (50% mastication), controlled by visual feedback with electromyogram. Gummy jelly was selected as a test food. The oropharynx was observed during the sequence of events from the start of mastication until swallowing using a nasal endoscope. The number of chewing strokes was calculated by rhythmical masseter muscle activity on electromyogram.Results
The number of chewing strokes increased with 50% mastication. There was a particularly noticeable increase in the number of pre-St2Tr strokes. No effect on the number of additional swallows was seen as a result of 50% mastication.Conclusions
The present study supported the hypothesis that intentional decrease in the muscle activity during mastication affected the number of chewing strokes and the occurrence of St2Tr. Particularly, this tendency was noticeable during the mastication before the start of St2Tr. However, our results did not support a question as to the number of swallowing. 相似文献960.
Shintaro Sawada Jun-ichi Okano Ryu Imamoto Yuki Yasunaka Ryo Abe Masahiko Koda Yoshikazu Murawaki Hajime Isomoto 《Yonago acta medica》2016,59(1):37-43