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91.
Parag Mahale Megan M. Herr Eric A. Engels Ruth M. Pfeiffer Meredith S. Shiels 《British journal of haematology》2020,188(4):516-521
Primary central nervous system lymphoma (PCNSL) risk is highly increased in immunosuppressed individuals, such as those with human immunodeficiency virus infection and solid organ transplant recipients, but rates are increasing among immunocompetent older adults (age ≥65 years). We utilized data from a large, nationally-representative cohort of older adults in the United States and found that PCNSL is significantly associated with systemic lupus erythematosus, polyarteritis nodusa, autoimmune hepatitis, myasthenia gravis and uveitis. Immunosuppressive drugs given to treat these conditions may increase PCNSL risk, but these associations cannot explain the observed temporal increase in PCNSL rates, given the low prevalence of these conditions. 相似文献
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Martine M. Groefsema Gabry W. Mies Janna Cousijn Rutger C. M. E. Engels Guillaume Sescousse Maartje Luijten 《The European journal of neuroscience》2020,51(6):1491-1503
Alcohol is mainly consumed in social settings, in which people often adapt their drinking behaviour to that of others, also called imitation of drinking. Yet, it remains unclear what drives this drinking in a social setting. In this study, we expected to see stronger brain and behavioural responses to social compared to non‐social alcohol cues, and these responses to be associated with drinking in a social setting. The sample consisted of 153 beer‐drinking males, aged 18–25 years. Brain responses to social alcohol cues were measured during an alcohol cue‐exposure task performed in an fMRI scanner. Behavioural responses to social alcohol cues were measured using a stimulus‐response compatibility task, providing an index of approach bias towards these cues. Drinking in a social setting was measured in a laboratory mimicking a bar environment. Specific brain responses to social alcohol cues were observed in the bilateral superior temporal sulcus and the left inferior parietal lobe. There was no approach bias towards social alcohol cues specifically; however, we did find an approach bias towards alcohol (versus soda) cues in general. Brain responses and approach bias towards social alcohol cues were unrelated and not associated with actual drinking. Thus, we found no support for a relation between drinking in a social setting on the one hand, and brain cue‐reactivity or behavioural approach biases to social alcohol cues on the other hand. This suggests that, in contrast to our hypothesis, drinking in a social setting may not be driven by brain or behavioural responses to social alcohol cues. 相似文献
94.
Wijnhoven Lieke A. M. W. Engels Rutger C. M. E. Onghena Patrick Otten Roy Creemers Daan H. M. 《Journal of autism and developmental disorders》2022,52(1):150-168
Journal of Autism and Developmental Disorders - The aim of the present study was to examine the additive effect of elements of cognitive behavioral therapy (CBT) on the video game Mindlight in... 相似文献
95.
Mirjam W. Lammers Maartje S. Vroling Machteld A. Ouwens Rutger C. M. E. Engels Tatjana van Strien 《European eating disorders review》2015,23(3):219-228
The aim of this naturalistic study was to identify pretreatment predictors of response to cognitive behaviour therapy in treatment‐seeking patients with binge eating disorder (BED; N = 304). Furthermore, we examined end‐of‐treatment factors that predict treatment outcome 6 months later (N = 190). We assessed eating disorder psychopathology, general psychopathology, personality characteristics and demographic variables using self‐report questionnaires. Treatment outcome was measured using the bulimia subscale of the Eating Disorder Inventory 1. Predictors were determined using hierarchical linear regression analyses. Several variables significantly predicted outcome, four of which were found to be both baseline predictors of treatment outcome and end‐of‐treatment predictors of follow‐up: Higher levels of drive for thinness, higher levels of interoceptive awareness, lower levels of binge eating pathology and, in women, lower levels of body dissatisfaction predicted better outcome in the short and longer term. Based on these results, several suggestions are made to improve treatment outcome for BED patients. Copyright © 2015 John Wiley & Sons, Ltd and Eating Disorders Association. 相似文献
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Regina Alessandri Bieri Laurence Adriaens Stefan Spörri Niklaus P. Lang G. Rutger Persson 《Clinical oral investigations》2013,17(1):19-28
Objectives
The aim of this study was to assess gingival fluid (GCF) cytokine messenger RNA (mRNA) levels, subgingival bacteria, and clinical periodontal conditions during a normal pregnancy to postpartum.Materials and methods
Subgingival bacterial samples were analyzed with the checkerboard DNA–DNA hybridization method. GCF samples were assessed with real-time PCR including five proinflammatory cytokines and secretory leukocyte protease inhibitor.Results
Nineteen pregnant women with a mean age of 32 years (S.D. ± 4 years, range 26–42) participated in the study. Full-mouth bleeding scores (BOP) decreased from an average of 41.2% (S.D. ± 18.6%) at the 12th week of pregnancy to 26.6% (S.D. ± 14.4%) at the 4–6 weeks postpartum (p?<?0.001). Between week 12 and 4–6 weeks postpartum, the mean probing pocket depth changed from 2.4 mm (S.D. ± 0.4) to 2.3 mm (S.D. ± 0.3) (p?=?0.34). Higher counts of Eubacterium saburreum, Parvimonas micra, Selenomonas noxia, and Staphylococcus aureus were found at week 12 of pregnancy than at the 4–6 weeks postpartum examinations (p?<?0.001). During and after pregnancy, statistically significant correlations between BOP scores and bacterial counts were observed. BOP scores and GCF levels of selected cytokines were not related to each other and no differences in GCF levels of the cytokines were observed between samples from the 12th week of pregnancy to 4–6 weeks postpartum. Decreasing postpartum counts of Porphyromonas endodontalis and Pseudomonas aeruginosa were associated with decreasing levels of Il-8 and Il-1β.Conclusions
BOP decreased after pregnancy without any active periodontal therapy. Associations between bacterial counts and cytokine levels varied greatly in pregnant women with gingivitis and a normal pregnancy outcome. Postpartum associations between GCF cytokines and bacterial counts were more consistent.Clinical relevance
Combined assessments of gingival fluid cytokines and subgingival bacteria may provide important information on host response. 相似文献98.
Florian Beuer Dr med dent PhD Josef Schweiger CDT Martin Huber BSc Jörg Engels Dr med dent Michael Stimmelmayr Dr med dent PhD 《Journal of prosthodontics》2014,23(4):333-336
Various treatment concepts have been presented for the edentulous mandible. Manufacturing tension‐free and precisely fitting bars on dental implants was previously a great challenge in prosthetic dentistry and required great effort. Modern computer aided design/computer aided manufacturing technology in combination with some clinical modifications of the established workflow enables the clinician to achieve precise results in a very efficient way. The innovative five‐step concept is presented in a clinical case. 相似文献
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100.