全文获取类型
收费全文 | 8221篇 |
免费 | 717篇 |
国内免费 | 11篇 |
专业分类
耳鼻咽喉 | 170篇 |
儿科学 | 373篇 |
妇产科学 | 217篇 |
基础医学 | 936篇 |
口腔科学 | 227篇 |
临床医学 | 650篇 |
内科学 | 2135篇 |
皮肤病学 | 258篇 |
神经病学 | 565篇 |
特种医学 | 258篇 |
外科学 | 1458篇 |
综合类 | 26篇 |
一般理论 | 2篇 |
预防医学 | 711篇 |
眼科学 | 193篇 |
药学 | 385篇 |
中国医学 | 34篇 |
肿瘤学 | 351篇 |
出版年
2023年 | 35篇 |
2022年 | 78篇 |
2021年 | 224篇 |
2020年 | 124篇 |
2019年 | 284篇 |
2018年 | 276篇 |
2017年 | 199篇 |
2016年 | 209篇 |
2015年 | 212篇 |
2014年 | 299篇 |
2013年 | 379篇 |
2012年 | 431篇 |
2011年 | 512篇 |
2010年 | 347篇 |
2009年 | 258篇 |
2008年 | 396篇 |
2007年 | 446篇 |
2006年 | 457篇 |
2005年 | 423篇 |
2004年 | 384篇 |
2003年 | 369篇 |
2002年 | 357篇 |
2001年 | 304篇 |
2000年 | 356篇 |
1999年 | 253篇 |
1998年 | 66篇 |
1997年 | 52篇 |
1996年 | 55篇 |
1995年 | 47篇 |
1994年 | 38篇 |
1993年 | 35篇 |
1992年 | 133篇 |
1991年 | 115篇 |
1990年 | 102篇 |
1989年 | 98篇 |
1988年 | 55篇 |
1987年 | 54篇 |
1986年 | 47篇 |
1985年 | 50篇 |
1984年 | 34篇 |
1983年 | 29篇 |
1979年 | 27篇 |
1975年 | 20篇 |
1974年 | 18篇 |
1973年 | 24篇 |
1972年 | 22篇 |
1971年 | 21篇 |
1970年 | 18篇 |
1969年 | 22篇 |
1968年 | 19篇 |
排序方式: 共有8949条查询结果,搜索用时 15 毫秒
101.
Expression profiling of T-cell lymphomas differentiates peripheral and lymphoblastic lymphomas and defines survival related genes. 总被引:1,自引:0,他引:1
Beatriz Martinez-Delgado Barbara Meléndez Marta Cuadros Javier Alvarez Jose Maria Castrillo Ana Ruiz De La Parte Manuela Mollejo Carmen Bellas Ramon Diaz Luis Lombardía Fatima Al-Shahrour Orlando Domínguez Alberto Cascon Mercedes Robledo Carmen Rivas Javier Benitez 《Clinical cancer research》2004,10(15):4971-4982
PURPOSE: T-Cell lymphomas constitute heterogeneous and aggressive tumors in which pathogenic alterations remain largely unknown. Expression profiling has demonstrated to be a useful tool for molecular classification of tumors. EXPERIMENTAL DESIGN: Using DNA microarrays (CNIO-OncoChip) containing 6386 cancer-related genes, we established the expression profiling of T-cell lymphomas and compared them to normal lymphocytes and lymph nodes. RESULTS: We found significant differences between the peripheral and lymphoblastic T-cell lymphomas, which include a deregulation of nuclear factor-kappaB signaling pathway. We also identify differentially expressed genes between peripheral T-cell lymphoma tumors and normal T lymphocytes or reactive lymph nodes, which could represent candidate tumor markers of these lymphomas. Additionally, a close relationship between genes associated to survival and those that differentiate among the stages of disease and responses to therapy was found. CONCLUSIONS: Our results reflect the value of gene expression profiling to gain insight about the molecular alterations involved in the pathogenesis of T-cell lymphomas. 相似文献
102.
103.
104.
105.
106.
107.
Susana Puig Josep Malvehy Cèlia Badenas Anna Ruiz Dolores Jimenez Francisco Cuellar Antoni Azon Urbá Gonzàlez Teresa Castel Antoni Campoy Josep Herrero Rosa Martí Joan Brunet-Vidal Montserrat Milà 《Journal of clinical oncology》2005,23(13):3043-3051
PURPOSE: We have studied a consecutive case series of patients with multiple primary melanoma (MPM) for the involvement of the melanoma susceptibility loci CDKN2A and CDK4. PATIENTS AND METHODS: One hundred four MPM patients (81 patients with two primary melanomas, 14 with three, five with four, one with five, two with six, and one with seven) were included. RESULTS: Seven different CDKN2A germline mutations were identified in 17 patients (16.3%). In total, we identified 15 CDKN2A exon 2, one exon 1alpha missense mutation, and one exon 1beta frameshift mutation. The age of onset was significantly lower and the number of primary melanomas higher in patients with mutations. CDKN2A mutations were more frequent in patients with familial history of melanoma (35.5%) compared with patients without (8.2%), with a relative risk (RR) of 4.32 (95% CI, 1.76 to 10.64; P = .001), and in patients with more than two melanomas (39.1%) compared with patients with only two melanomas (10%) with an RR of 3.29 (95% CI, 1.7 to 6.3; P = .002). The A148T polymorphism was more frequent in patients with MPMs than in the control population (P = .05). A variant of uncertain significance, A127S, was also detected in one patient. No CDK4 mutations were identified, suggesting that it has a low impact in susceptibility to MPM. CONCLUSION: MPM patients are good candidates for CDKN2A mutational screening. These patients and some of their siblings should be included in a program of specific follow-up with total body photography and digital dermoscopy, which will result in the early detection of melanoma in this subset of high-risk patients and improve phenotypic characterization. 相似文献
108.
Llau Pitarch JV Díaz Alvarez A Polonio Enríquez F Castro Santamaría M Ruiz Moyano J García Enguita MA 《Revista espa?ola de anestesiología y reanimación》2000,47(7):309-316
Aprotinin is a protease inhibitor of interest for its antifibrinolytic effect of reducing perioperative bleeding in certain types of surgery, with wide use in heart surgery, liver transplantation and vascular surgery. The application of aprotinin during orthopedic surgery has recently been suggested. Such use is controversial, as there is lack of consensus as to the type of patient for whom aprotinin administration would be indicated, the surgical procedure during which it would be most effective (hip or knee arthroplasty, spinal arthrodesis, major tumor or septic surgery), the doses to administer, its safety and its real efficacy for conserving homologous blood. That is to say, there is no agreement as to the cost/benefit relation of aprotinin for the various types of orthopedic surgery. This critical review of the literature leads to the conclusion that aprotinin is a promising drug for use in orthopedic surgery, given that published studies have established the benefit in blood product savings and decreased blood loss during surgery. 相似文献
109.
Left ventricular pseudoaneurysm and ventricular septal defect are rare but devastating complications of myocardial infarction. With medical treatment alone, the majority of patients will die from these complications. Until recently, the recommended treatment was surgical closure. These surgeries carried extreme risk due to abnormal hemodynamics, necrotic substrates and the comorbidities of these patients. Recently, trans-catheter closure was shown to be an acceptable alternative to open surgical intervention. 3D echocardiography identifies the location, size, and shape of the defect and can assess, guide, and follow up the closure procedure. 相似文献
110.