Short stature, abdominal obesity, insulin resistance and alterations in lipid profile in very low-income women living in Maceió, north-eastern Brazil.

OBJECTIVE: To test the hypothesis that short stature is associated with abdominal obesity, insulin resistance and lipid profile changes. METHODS: Anthropometric data were collected from 237 women (18-60 years old), residents of a shantytown in Maceió. Biochemical profiles of 60 individuals drawn from this population were determined. RESULTS: Total and low-density lipoprotein (LDL) cholesterol levels and insulin resistance rose with increasing waist : hip circumference ratio, particularly in women. Short, overweight individuals exhibited larger biochemical alterations than overweight individuals of average stature. CONCLUSION: Short stature, when associated with overweight, is a risk factor for increased insulin resistance and alterations in lipid profile.     

肝腺瘤的影像学诊断

目的探讨影像学(US、CT、MRI及DSA)诊断肝腺瘤的价值。方法回顾性分析经手术、病理证实的11例肝腺瘤的影像学表现,其中11例行US和CT检查(有1例行CT灌注成像,CTP),5例行MRI扫描,4例行DSA检查,并与手术病理所见对照。结果11例肝腺瘤均为单发肿块,无肝硬化背景,直径2.0～10.0cm。影像学表现:US检查,10例呈稍低或不均匀稍强回声,边界清晰,6例见低回声晕,彩色多普勒显示肿块内有较丰富的血流;CT检查,10例为稍低或等密度,8/10例动脉期全瘤明显强化,门脉期轻度强化,延迟期呈等密度,1例平扫和延迟期呈等密度,动脉期中度强化,门脉期轻度强化,误诊为血管瘤。1/11例CT灌注成像(CTP)检查,肝动脉灌注量(HAP)=1.08ml/(min.ml),门静脉灌注量(PVP)=0.19ml/(min.ml),肝动脉灌注指数(HPI)=0.85,各参数值与肝癌均有明显不同;MRI检查,5例肝腺瘤均能显示完整包膜,T1WI上2例稍高于肝脏信号,1例呈等信号,2例为稍低信号,T2WI上5例均表现为以稍高信号为主的混杂信号,脂肪抑制像(STIR)1例呈略低信号,4例信号与T2WI相似,行增强扫描的4例病灶动脉期显著强化,门脉期强化减退,平衡期呈等信号。DSA检查,3/4例病灶见粗细不均的异常血管影,实质期可见肿瘤染色表现。结论肝腺瘤的US和DSA表现均缺乏特异性,CT、MRI则具有一定的特点。CTP对肝腺瘤可能具有诊断和鉴别诊断价值。     

VEGF在肺癌组织中的表达及临床意义

目的：探讨血管内皮生长因子在肺癌中的表达情况与肺癌病理生物学行为之间的关系。方法：采用免疫组化SP法检测47例肺癌组织和10正常肺组织中VEGF的表达水平。结果：肺癌组织中VEGF的表达明显高于正常肺组织(P＜0．005)，P53、VEGF表达与肺癌的分化程度、淋巴结转移及P—TNM分期密切相关(P＜0．05)，与患者的性别、年龄、肿瘤大小及组织类型无关(P＞0．05)。结论：检测肺癌组织中VEGF的表达水平有助于了解肿瘤的生物学行为，并可作为判断其预后的有价值指标。     

A rare polymorphism affects a mitogen-activated protein kinase site in synapsin III: possible relationship to schizophrenia.

BACKGROUND: Synapsin III plays a role in neuronal plasticity and maps to chromosome 22q12-13, a region suggested to be linked to schizophrenia. To determine if synapsin III plays a role in this disease, we searched for polymorphisms in this gene in patients with schizophrenia and controls. METHODS: The synapsin III gene was initially sequenced from 10 individuals with schizophrenia to identify polymorphisms. Association analysis was then performed using 118 individuals with schizophrenia and 330 population controls. Synapsin III expression was studied by immunoblot analyses, and phosphorylation sites were mapped by sequencing trypsin-digested synapsin III fragments phosphorylated with phosphorus-32. RESULTS: A rare, missense polymorphism, S470N, was identified in the synapsin III gene and appeared more frequently in individuals with schizophrenia than in controls (p =.0048). The site affected by the polymorphism, Ser470, was determined to be a substrate for mitogen-activated protein kinase, a downstream effector of neurotrophin action. Phosphorylation at Ser470 was increased during neonatal development and in response to neurotrophin-3 in cultured hippocampal neurons. CONCLUSIONS: Our observations suggest an association of a rare polymorphism in synapsin III with schizophrenia, but further studies will be required to clarify its role in this disease.     

使用电力载波技术实现中央控制电子钟

本文应用电力载波技术，实现远端时钟的中央控制。系统通过电力载波芯片从电力线上收发控制信号，中央控制端发送的时钟校准信号到电力线网络，接人网络的远端时钟接收到校准信号后，由微处理器解析数据调整受控端时钟显示，从而实现时钟的中央控制。     

过氧化氢对不同时相HepG2细胞氧化作用的研究

背景与目的:研究过氧化氢(H2O2)对不同时相HepG2细胞作用的选择性,以进一步探讨H2O2:诱导肿瘤细胞凋亡的机制.材料与方法:以胸腺嘧啶核苷(TdR)阻断法获得不同细胞周期时相的同步化细胞,分别加入800 μmol/L的H2O2作用3 h,并检测各组细胞的丙二醛(MDA)含量、黄嘌呤氧化酶(XOD)和5'核苷酸酶(5'NT)的活性及抗羟自由基(抗·OH)和抗超氧阴离子自由基(抗O2)的活性.结果:经H2O2处理的各组MDA含量和XOD、抗·OH、抗O2活性显著高于对照组,其差异均具有统计学意义(P均＜0.01),5'NT活性低于对照组(P＜0.01).与未同步化组比较,同步化于S期和G2/M期的细胞MDA含量和XOD、5'NT、抗·OH和抗O2活性显著升高,其差异均具有统计学意义(P均＜0.01),而同步化于G1期的细胞MDA含量、XOD、5'NT和抗O2-活性显著降低,差异均具有统计学意义(P均＜0.01).结论:H2O2作用同步化HepG2细胞后,代谢产生自由基的酶活性,脂质过氧化产物含量以及抗氧化水平均表现出细胞周期特异性,这可能是过氧化氢对不同时相HepG2细胞损伤作用不同的原因.     

不同起搏模式对病人生存质量影响的调查研究

[目的]探讨不同起搏模式对病人生存质量（QOL）的影响。[方法]以健康调查问卷（SF一36量表）对112例不同起搏模式病人进行问卷调查，比较3种起搏模式下病人的QOL水平。[结果]除机体疼痛、角色情绪2个维度外其余6个维度（生理功能、角色限制、活力、社会功能、精神健康、总体健康）3种起搏模式间比较差异有统计学意义（P〈0．05）。[结论]应用AAI型、DDD型起搏器的病人生存质量优于VVI型起搏。     

以杯[4]芳烃衍生物为载体的钾离子选择电极的研究

目的：研制新的以杯[4]芳烃衍生物为载体的PVC膜钾离子选择电极。方法：以3种杯[4]芳烃衍生物为载体，癸二酸二辛酯或邻苯二甲酸二辛酯为增塑剂，四（4－氯）苯硼钾为离子定域体制得了PVC膜钾离子选择电极，测试了该类电极对钾离子的响应性能和对7种阳离子的选择性系数。结果：以5，11，17，23－四叔丁基－25，26，27，28－四[2-(乙氧基羰基）苄氧基]杯[4]芳烃为载体所制得的电极（电极Ⅰ）对钾离子有良好的能斯特响应，该电极的选择性系数优于电极Ⅱ和Ⅲ。分别用电极Ⅰ，Ⅱ，Ⅲ对青霉素V钾中的钾含量进行了测定，其结果均与原子吸收法基本一致。结论：所制得的上述电极是一类新的钾离子选择电极，有实用价值。