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Glial injury in neurotoxicity after pediatric CD19‐directed chimeric antigen receptor T cell therapy
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Claudia Brizuela Andrea Ormeño Carolina Cabrera Roxana Cabezas Carolina Inostroza Silva Valeria Ramírez Montse Mercade 《Journal of endodontics》2017,43(11):1776-1780
Introduction
Direct pulp capping treatment is intended to preserve pulp vitality, to avoid or retard root canal treatment, and, in cases with an open apex, to allow continued root development. Historically, calcium hydroxide (CH) was the gold standard material, but nowadays calcium silicate materials (CSMs) are displacing CH because of their high bioactivity, biocompatibility, sealing ability, and mechanical properties. However, more randomized clinical trials are needed to confirm the appropriateness of CSMs as replacement materials for CH in direct pulp capping procedures.Methods
A randomized clinical trial was conducted that included 169 patients (mean age, 11.3 years) from the Maipo district (Chile). The inclusion criterion was patients with 1 carious permanent tooth with pulpal exposure, a candidate for a direct pulp capping procedure. The patients were randomly allocated to one of the experimental groups (CH, Biodentine, or mineral trioxide aggregate [MTA]). Clinical follow-up examinations were performed at 1 week, 3 months, 6 months, and 1 year. The Fisher exact test was performed.Results
At the follow-up examination at 1 week, the patients showed 100% clinical success. At 3 months, there was 1 failure in the CH group. At 6 months, there were 4 new failures (1 in the CH group and 3 in the MTA group). At 1 year, there was another failure in the CH group. There were no statistically significant differences among the experimental groups.Conclusions
CSMs appear to be suitable materials to replace CH. Although no significant differences were found among the materials studied, Biodentine and MTA offered some advantages over CH. 相似文献995.
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Emily C. Davis Mary Jane Rotheram-Borus Thomas W. Weichle Roxana Rezai Mark Tomlinson 《AIDS and behavior》2017,21(2):174-182
Alcohol is a major contributor to the global burden of disease. In South Africa, alcohol abuse is hypothesized to correlate with women’s HIV status, mental health, and partner relationships over time. All pregnant women in 12 urban, low-income, Cape Town neighborhoods were interviewed at baseline, post-birth, and at 6, 12, 36, and 60 months following delivery with retention rates from 82.5 to 94%. Women were assessed for any alcohol use, problematic drinking, depression, intimate partner violence, and HIV status. Prior to pregnancy discovery and 5 years after giving birth, alcohol use was 25.8 and 24.7%, respectively. Most women decreased their alcohol use during pregnancy. Twenty-one percent reported alcohol use on two or more assessments, and only 15% of the mothers drinking alcohol at 5 years were also drinking at baseline. Mothers with depression had a higher likelihood of drinking alcohol compared to mothers who were not depressed only at baseline and 6 months post-birth. Mothers who experienced IPV had more than twice the likelihood of drinking alcohol compared to non-IPV mothers at all assessments. HIV positive mothers were more likely to drink alcohol compared to mothers without HIV prior to pregnancy discovery and at 5 years post-birth. These longitudinal trends in alcohol use among young women in South Africa represent a large economic, social, and health burden and must be addressed in a comprehensive manner. 相似文献
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Ron C. Gaba R. Peter Lokken Ryan M. Hickey Andrew J. Lipnik Robert J. Lewandowski Riad Salem Daniel B. Brown T. Gregory Walker James E. Silberzweig Mark Otto Baerlocher Ana Maria Echenique Mehran Midia Jason W. Mitchell Siddharth A. Padia Suvranu Ganguli Thomas J. Ward Jeffrey L. Weinstein Boris Nikolic Sean R. Dariushnia 《Journal of vascular and interventional radiology : JVIR》2017,28(9):1210-1223.e3
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