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排序方式: 共有646条查询结果,搜索用时 15 毫秒
81.
阿片受体拮抗剂在TNF-α所致体温升高中的作用 总被引:1,自引:0,他引:1
为探索细胞介素TNF-α升体温效应与下丘脑前部、视前区(POAH)中的阿片受体的关系。应用脑神经核团微量注射方法给自由状态下的雄性SD大鼠POAH区微量注射TNF-α致热源。给药前30min分别用通常阿片受体拮抗剂Nal(10~20μg)和特异性阿片受体μ、δ和κ的拮抗剂CTAP(1.0~2.5μg)、NTI(0.25~0.5μg)和nor-BNI(0.1~3μg)对POAH做预处理。结果:单独给TNF-α可致剂量相关的体温升高△T(1℃~1.4℃);经Nal10μg,CTAP1.0μg和NTI0.5μg处理后使TNF-α的升体温效应减弱;用Nal20μg,CTAP2.5μg和NTI0.25μg处理后可完全阻断TNF-α所致的体温升高;nor-BNI(0.1~3μg)对TNF-α的升体温效应无影响。 相似文献
82.
83.
Long-term follow-up of autoantibody profiles in black female lupus patients and clinical comparison with Caucasian and Asian patients 总被引:5,自引:4,他引:1
The aim was to determine whether the autoantibody profile in Black female
lupus patients is associated with clinical subsets, fluctuates over time
and/or reflects disease activity. A clinical comparison with Caucasian and
Asian patients matched for age of onset and disease duration was also
undertaken. Up to seven serial bleeds from Black female lupus patients who
had been followed up for periods of 3.15 yr were tested for antibodies to
Ro/SSA, La SSB. Sm, RNP and ribosomal P using ELISA research assays.
Significant differences in both clinical and serological profiles between
the ethnic groups were found. Varying aspects of disease activity were
linked to anti-DNA (renal, cardiovascular, global score), anti-ribosomal P
(musculoskeletal, haematology) and anti-Sm (general) antibodies. There are
differences in clinical and serological profiles amongst systemic lupus
erythematosus patients of different ethnic origin. However, using the BILAG
system, relatively few antibodies were found to reflect disease activity
accurately in serial measurements.
相似文献
84.
85.
Synovial cysts and synovialomas of the lumbar spine. Histo-pathologic and neuro-surgical aspects apropos of 8 cases 总被引:2,自引:0,他引:2
P Rousseaux J F Durot M Pluot M H Bernard B Scherpereel A Bazin P Peruzzi J C Baudrillard 《Neuro-Chirurgie》1989,35(1):31-39
Based on 8 personal cases and a 81-cases review of literature, it's authors' opinion that cystic or solid masses issued form posterior lumbar articular process and called according to the cases synovial cyst, ganglion cyst, benign synovialoma, pigmented villonodular synovitis, are a single variety of benign degeneration of soft articular tissues. The cystic or solid feature of these masses depends upon the extent of their histiocytic granulomatous proliferation. They may be asymptomatic, accompany chronic lumbar pain or cause sciatica, seldom cauda equina syndrome. In case of sciatica, clinical picture rather consists of a narrow lateral recess than a discal protrusion. CT scan is the best investigation to get a right preoperative diagnosis. Postoperative prognosis is excellent and no anatomical recurrence has been reported. 相似文献
86.
87.
Male CD-1 mice were exposed to a commercial formulation of 2,4-dichlorophenoxyacetic acid (2,4-D), the amine derivative, in the drinking water at concentrations ranging from 0 to 0.163% of the formulated product, equivalent to approximately 0-50 mg kg-1 day-1 2,4-D content. The effect of 2,4-D on urethan-induced pulmonary adenoma formation was evaluated following a 105-day exposure. Urethan-induced sleeping times observed following an i.p. injection of urethan (1.5 mg g-1) after 3 weeks of 2,4-D exposure were not altered by 2,4-D, indicating that 2,4-D did not influence urethan elimination. Pulmonary adenoma production, which was evaluated 84 days after urethan injection, was enhanced by 2,4-D exposure but had no effect on tumor size. The effect of 2,4-D on the incidence of spontaneous murine lymphocytic leukemia was evaluated during the 365-day treatment period. Mortality associated with the leukemia virus was not altered by 2,4-D treatment. Exposure to this commercial 2,4-D product at moderately high levels of exposure may modify the development or expression of certain tumors in CD-1 mice. The mechanism of the co-carcinogenic or tumor-promoting activity associated with 2,4-D exposure remains to be determined. 相似文献
88.
89.
Matson GB; Twieg DB; Karczmar GS; Lawry TJ; Gober JR; Valenza M; Boska MD; Weiner MW 《Radiology》1988,169(2):541-547
Localized phosphorus-31 magnetic resonance (MR) spectroscopy in humans has previously been accomplished with surface coils by means of depth-resolved surface coil spectroscopy or rotating frame experiments, in which the extent of tissue sampled critically depends on surface coil placement. The authors' goal was to modify the surface coil image-selected in vivo spectroscopy (ISIS) experiment to accomplish three-dimensional volume selection through application of selective pulses in the presence of B0 gradients. Advantages of ISIS include the ability to use proton images to define the volume of interest (VOI) and reduced dependence on exact positioning of the surface coil. However, rapid replication of the surface coil ISIS experiment can cause spectral contamination from signals originating outside the VOI. A modified version of the ISIS experiment was developed to alleviate contamination under conditions of rapid replication. Applications of localized P-31 MR spectroscopy for observation of high-energy phosphorus metabolites are presented in human liver, heart, and transplanted and normal kidney. 相似文献
90.
Spinal dysraphia and elongated spinal cord in adults 总被引:1,自引:0,他引:1
Spinal dysraphia with stretching of the spinal cord is usually diagnosed in the adolescent or young-adult patient. Two types of the condition are distinguished: a stretched spinal cord with an intradural lipoma, and a stretched spinal cord with both an intra- and extradural lipoma. The pathogenesis of the condition and mechanical role of the lipoma and the late appearing neurological signs are presented. 相似文献