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Anne Lübbeke Guido Garavaglia Kenneth J. Rothman Alexis Bonvin Constantinos Roussos Hermes Miozzari Pierre Hoffmeyer 《Journal of orthopaedic research》2013,31(5):814-820
In experimental studies, statin use has been associated with reduction of osteoclastic activity and promotion of bone formation around implants. Moreover, a large clinical study recently reported a substantially reduced risk of revision for aseptic loosening among statin users with THA. Our objective was to evaluate the influence of statin use on the development of femoral osteolysis within 5 years after THA. We conducted a case‐cohort study including all THAs presenting with femoral osteolysis at the 5 year visit (cases) and compared them with those without osteolysis (controls). Cases and controls were identified from a cohort of primary THAs operated between 2001 and 2005. Seven hundred thirty‐five THAs were included, mean age 68 years. Five years after surgery osteolysis had developed around the femoral component of 40 THAs (5.4%). Ever‐use of statins was much less frequent among cases (5 of 40, 12.5%) than among controls (199 of 695, 28.6%). The crude risk ratio of femoral osteolysis among statin users was 0.36 (95% CI 0.14; 0.92). After adjusting for age, sex, activity level, BMI, diagnosis, bearing surface, and type of stem, the adjusted risk ratio was 0.38 (95% CI 0.15; 0.99). In conclusion, statin use was associated with a reduced risk of developing femoral osteolysis 5 years after THA. Statins may be useful for reducing the risk of implant failure following THA. © 2012 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 31: 814–820, 2013 相似文献
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Gilat Moran Marshall Nathaniel S. Testelmans Dries Buyse Bertien Lewis Simon J. G. 《Journal of neurology》2022,269(1):125-148
Journal of Neurology - Rapid Eye Movement sleep behavior disorder (RBD) is a parasomnia causing sufferers to physically act out their dreams. These behaviors can disrupt sleep and sometimes lead to... 相似文献
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Zonal differences in meniscus MR relaxation times in response to in vivo static loading in knee osteoarthritis 下载免费PDF全文
Nathaniel E. Calixto Deepak Kumar Karupppasamy Subburaj Justin Singh Joseph Schooler Lorenzo Nardo Xiaojuan Li Richard B. Souza Thomas M. Link Sharmila Majumdar 《Journal of orthopaedic research》2016,34(2):249-261
This study assessed the effects of static loading on MRI relaxation times of menisci in individuals with and without radiographic knee OA. High‐resolution fast spin‐echo (FSE) and T1ρ/T2 relaxation time MR sequences were obtained with and without loading at 50% body weight in 124 subjects. T1ρ/T2 relaxation times were calculated in menisci, and meniscus lesions were assessed through clinical grading. Student's t‐test compared OA and control unloaded relaxation times as well as within‐group changes with loading, Generalized Linear Models evaluated zonal variation, and ANCOVA compared loading response between groups. Unloaded T1ρ and T2 in the middle and inner zones of the lateral anterior horn and outer zone of the medial posterior horn were significantly higher in OA and suggest that meniscal OA change occurs unevenly. Zonal T1ρ and T2 showed differing patterns between anterior and posterior horns, suggesting differences in macromolecular organization. Significant increases with loading were seen largely in the T2 of controls and less frequently in subjects with OA. In the medial posterior horn, T1ρ and T2 decreased with loading in OA but changed negligibly in controls; these significantly different loading responses between groups may indicate load transmission failure in OA menisci. © 2015 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 34:249–261, 2016. 相似文献
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William N. Evans Ruben J. Acherman Michael L. Ciccolo Sergio A. Carrillo Alvaro Galindo Abraham Rothman Brody J. Winn Noel S. Yumiaco Humberto Restrepo 《Pediatric cardiology》2016,37(7):1274-1277
We tested the hypothesis that MELD-XI values correlated with hepatic total fibrosis scores obtained in 70 predominately stable, post-Fontan patients that underwent elective cardiac catheterization. We found a statistically significant correlation between MELD-XI values and total fibrosis scores (p = 0.003). Thus, serial MELD-XI values may be an additional useful clinical parameter for follow-up care in post-Fontan patients. 相似文献