全文获取类型
收费全文 | 1296篇 |
免费 | 58篇 |
国内免费 | 16篇 |
专业分类
儿科学 | 54篇 |
妇产科学 | 17篇 |
基础医学 | 135篇 |
口腔科学 | 28篇 |
临床医学 | 138篇 |
内科学 | 227篇 |
皮肤病学 | 74篇 |
神经病学 | 52篇 |
特种医学 | 212篇 |
外科学 | 158篇 |
综合类 | 32篇 |
预防医学 | 27篇 |
眼科学 | 10篇 |
药学 | 166篇 |
肿瘤学 | 40篇 |
出版年
2022年 | 7篇 |
2021年 | 18篇 |
2020年 | 14篇 |
2019年 | 16篇 |
2018年 | 18篇 |
2017年 | 14篇 |
2016年 | 15篇 |
2015年 | 20篇 |
2014年 | 38篇 |
2013年 | 37篇 |
2012年 | 45篇 |
2011年 | 40篇 |
2010年 | 39篇 |
2009年 | 52篇 |
2008年 | 43篇 |
2007年 | 51篇 |
2006年 | 44篇 |
2005年 | 41篇 |
2004年 | 37篇 |
2003年 | 42篇 |
2002年 | 29篇 |
2001年 | 29篇 |
2000年 | 21篇 |
1999年 | 47篇 |
1998年 | 48篇 |
1997年 | 51篇 |
1996年 | 45篇 |
1995年 | 42篇 |
1994年 | 25篇 |
1993年 | 29篇 |
1992年 | 23篇 |
1991年 | 27篇 |
1990年 | 28篇 |
1989年 | 24篇 |
1988年 | 36篇 |
1987年 | 26篇 |
1986年 | 26篇 |
1985年 | 23篇 |
1984年 | 12篇 |
1983年 | 8篇 |
1982年 | 22篇 |
1981年 | 13篇 |
1980年 | 24篇 |
1979年 | 4篇 |
1978年 | 12篇 |
1977年 | 22篇 |
1976年 | 14篇 |
1975年 | 8篇 |
1971年 | 4篇 |
1967年 | 4篇 |
排序方式: 共有1370条查询结果,搜索用时 140 毫秒
71.
72.
73.
Multispectral analysis of magnetic resonance images 总被引:1,自引:0,他引:1
Magnetic resonance (MR) imaging systems produce spatial distribution estimates of proton density, relaxation time, and flow, in a two dimensional matrix form that is analogous to that of the image data obtained from multispectral imaging satellites. Advanced NASA satellite image processing offers sophisticated multispectral analysis of MR images. Spin echo and inversion recovery pulse sequence images were entered in a digital format compatible with satellite images and accurately registered pixel by pixel. Signatures of each tissue class were automatically determined using both supervised and unsupervised classification. Overall tissue classification was obtained in the form of a theme map. In MR images of the brain, for example, the classes included CSF, gray matter, white matter, subcutaneous fat, muscle, and bone. These methods provide an efficient means of identifying subtle relationships in a multi-image MR study. 相似文献
74.
We report a technique based on patient-controlled stimulation to restore analgesia after development of tolerance to deep brain stimulation (DBS). A 45-year-old female with neurogenic pain after cerebellar stroke underwent DBS implantation in the right ventralis caudalis (VC) thalamus with excellent stimulus-controlled analgesia for 29 months, followed by development of tolerance and loss of analgesia. Analgesia was restored when a stimulation module that allowed patient-controlled stimulation was implanted. 相似文献
75.
Cancer-related fatigue is one of the most common and disabling conditions referred by patients with neoplastic diseases. However, it is one of the symptoms related to cancer and its treatment, oncologists largely underestimate. The guidelines of the National Comprehensive Cancer Network on the diagnosis and treatment of this multifactorial pathology are illustrated. Attention is focused on the most recent evidences present in the literature about the therapeutic benefit of physical exercise and its effects on muscular function, cardiorespiratory performance and life quality of oncologic patients. 相似文献
76.
OBJECTIVE: To report a case of successful treatment of azole-refractory oropharyngeal candidiasis with topical amphotericin B. CASE SUMMARY: A 30-year-old white woman presented with recurrent oral thrush. The patient had been exposed to azole antifungals for >20 years, and in vitro susceptibility tests revealed class resistance. The patient started taking amphotericin B 100 mg oral suspension swish-and-spit 4 times daily. After 4 weeks of topical amphotericin B treatment, the patient reported significant symptomatic improvement. The oral candidiasis worsened following a course of oral antibiotics, but improved once the antibiotic was discontinued and after receiving amphotericin B swish-and-swallow for 4 additional weeks. DISCUSSION: Current Infectious Diseases Society of America guidelines include topical amphotericin B as a potentially effective option for the treatment of oropharyngeal candidiasis. There is limited evidence to support this recommendation. Besides lack of data, an appropriate dosing regimen and consistent means of product formulation need to be determined. CONCLUSIONS: This report demonstrates the potential role for topical amphotericin B in the treatment of azole-refractory oral candidiasis. Double-blind, randomized, controlled trials are needed to define dosing, efficacy, administration, and long-term safety of oral amphotericin B. 相似文献
77.
OBJECTIVE: To assess the clinical literature describing the use of ivermectin in cases of treatment-resistant scabies infestations. DATA SOURCES: Clinical literature accessed through a MEDLINE search (1966-July 2001) and the Cochrane Database. DATA SYNTHESIS: A limited number of case reports and case series describes successful intervention with ivermectin use in patients who have failed prior therapy. Ivermectin may serve as a viable alternative therapy as the incidence of resistant scabitic infestations increases. CONCLUSIONS: Ivermectin appears to be a safe and effective alternative for patients with treatment-resistant scabies. Larger, controlled clinical trials are required before this therapy can be recommended in the general population or as primary therapy. 相似文献
78.
79.
Manetti D Ghelardini C Bartolini A Bellucci C Dei S Galeotti N Gualtieri F Romanelli MN Scapecchi S Teodori E 《Journal of medicinal chemistry》2000,43(10):1969-1974
Several 4-substituted 1,4-diazabicyclo[4.3.0]nonan-9-ones have been synthesized and tested in vivo on mouse passive avoidance test, to evaluate their nootropic activity. The results show that they represent a new class of nootropic drugs with a pharmacological profile very similar to that of piracetam, showing much higher potency with respect to the reference. Among the compounds studied, 7 (DM 232) shows outstanding potency, being active at the dose of 0. 001 mg kg(-1) sc. 相似文献
80.