全文获取类型
收费全文 | 3249篇 |
免费 | 164篇 |
国内免费 | 34篇 |
专业分类
耳鼻咽喉 | 59篇 |
儿科学 | 92篇 |
妇产科学 | 86篇 |
基础医学 | 334篇 |
口腔科学 | 79篇 |
临床医学 | 288篇 |
内科学 | 738篇 |
皮肤病学 | 76篇 |
神经病学 | 273篇 |
特种医学 | 113篇 |
外科学 | 556篇 |
综合类 | 53篇 |
一般理论 | 3篇 |
预防医学 | 293篇 |
眼科学 | 68篇 |
药学 | 189篇 |
中国医学 | 7篇 |
肿瘤学 | 140篇 |
出版年
2023年 | 38篇 |
2022年 | 94篇 |
2021年 | 113篇 |
2020年 | 87篇 |
2019年 | 102篇 |
2018年 | 122篇 |
2017年 | 85篇 |
2016年 | 98篇 |
2015年 | 100篇 |
2014年 | 129篇 |
2013年 | 162篇 |
2012年 | 254篇 |
2011年 | 293篇 |
2010年 | 141篇 |
2009年 | 121篇 |
2008年 | 195篇 |
2007年 | 194篇 |
2006年 | 195篇 |
2005年 | 166篇 |
2004年 | 163篇 |
2003年 | 152篇 |
2002年 | 143篇 |
2001年 | 21篇 |
2000年 | 16篇 |
1999年 | 28篇 |
1998年 | 24篇 |
1997年 | 24篇 |
1996年 | 13篇 |
1995年 | 7篇 |
1994年 | 8篇 |
1993年 | 11篇 |
1992年 | 11篇 |
1991年 | 7篇 |
1990年 | 12篇 |
1989年 | 4篇 |
1988年 | 4篇 |
1987年 | 10篇 |
1986年 | 10篇 |
1985年 | 12篇 |
1984年 | 5篇 |
1983年 | 5篇 |
1982年 | 4篇 |
1981年 | 3篇 |
1980年 | 5篇 |
1979年 | 9篇 |
1978年 | 7篇 |
1977年 | 6篇 |
1976年 | 4篇 |
1972年 | 3篇 |
1937年 | 4篇 |
排序方式: 共有3447条查询结果,搜索用时 15 毫秒
991.
992.
Bowel dysfunction after laparoscopic antireflux surgery: incidence,severity, and clinical course 总被引:5,自引:0,他引:5
PURPOSE: To evaluate the incidence, severity, and clinical course of postoperative bowel dysfunction, primarily diarrhea, after laparoscopic antireflux surgery. METHODS: Patients who underwent laparoscopic antireflux surgery during January to December 1998 responded to a questionnaire about pre-existing and postoperative bowel symptoms, which included questions about the type of bowel dysfunction (diarrhea, abdominal pain, bloating, constipation), onset in relation to surgery, frequency, severity, duration, use of medical resources or diagnostic evaluations, and treatment outcome. RESULTS: Of the 109 patients who underwent laparoscopic antireflux surgery at our center during the study, 84 (77%) completed the survey. Thirty-six (43%) had no bowel dysfunction before or after surgery, whereas 29 (35%) had pre-existing bowel dysfunction. New bowel symptoms developed postoperatively in 30 patients (36%), including bloating in 16 (19%) and diarrhea in 15 (18%). Two thirds of the patients with new diarrhea developed it within 6 weeks after surgery. The severity of the diarrhea ranged from mild to debilitating; 4 had fecal incontinence. Most patients (13/15) with diarrhea had symptoms for > or =2 years following surgery. No patient was hospitalized, and only 2 patients reported temporary work loss. CONCLUSION: Postoperative bowel dysfunction, namely diarrhea, is an important adverse effect of antireflux surgery. Awareness of this complication should lead to prompt recognition, effective management, and reduction in anxiety. 相似文献
993.
994.
A new series of 2-substituted mercapto-3H-quinozolines bearing 6-iodo and 2-heteroarylthio functions was synthesized and screened for their in vitro antitumor activity. Eighteen compounds were identified as active anticancer agents. N'-[(3-Benzyl-4-oxo-6-iodo-3H-quinazoline-2-yl)thioacetyl]-N(3)-ethylthiosemicarbazide (10), N-benzoyl-N'-[2-(3-benzyl-4-oxo-6-iodo-3H-quinozolin-2-yl)thioacetyl]hydrazine (12), and 2-[(3, 6-dioxo-pyridazin-4-yl)thio]-3-benzyl-4-oxo-6-iodo-3H-quinazoline (20) proved to be the most active members in this study. They showed MG-MID, GI(50) values of 12.8, 11.3, and 13.8 microM, respectively. The detailed synthesis and biological screening data are reported. 相似文献
995.
Opinion statement Mucosa-associated lymphoid tissue (MALT) lymphomas occur in a variety of organs, including the orbit, conjunctiva, salivary
glands, skin, thyroid gland, lungs, stomach, and intestine. These tumors are often localized and of indolent clinical behavior.
Diagnosis is made by pathologic evaluation of a tissue biopsy. Careful staging is mandatory and tailored to the initial presentation.
Staging includes a history and physical, chemistries, computed tomography scan, and bone marrow biopsy. This information is
supplemented with an ear, nose, and throat consultation, esophagogastro-duodenoscopy, colonoscopy, endoscopic ultrasound of
the stomach, and cytogenetic/immunohistochemical analysis of the tumors. Treatment is tailored to organ involvement and stage
at presentation. Eradication of Helicobacter pylori using a triple anti-H. pylori regimen approved by the US Food and Drug Administration is standard therapy for all H.
pyloripositive gastric MALT lymphomas. Endoscopic ultrasound- and computed tomographystaged gastric MALT stage IE tumors will achieve
a complete response with this approach in approximately 60% to 90% of patients (the more superficial the tumor [T1/T2], the
better the response). Patients with tumors that are T4 node-positive Musshoff stage IIE1 and IIE2 or tumors with adverse cytogenetics
should receive radiotherapy or surgery with or without radiotherapy. Tumors with a significant high-grade component or large
cell tumors with a minor low-grade MALT component should receive CHOP (cyclophosphamide, doxorubicin, vincristine, and prednisone)-based
chemotherapy. Localized MALT lymphomas of the orbit, conjunctiva, salivary glands, and thyroid gland are treated successfully
with radiotherapy. Surgery as first-line therapy for gastric MALT lymphomas was replaced by attempts at organ preservation.
In the past, margin-free surgical excision or tumor debulking followed by radiation therapy and chemotherapy has been highly
effective for gastric MALT lymphomas. Therefore, surgical excision of large cell or bulky tumors of the stomach, thyroid,
lung, and salivary gland, followed by adjuvant radiotherapy or chemotherapy, may still be an important consideration in selected
patients. Surgery still has a role for patients with relapsed or refractory lowgrade disease and life-threatening hemorrhage.
Disseminated MALT lymphomas are incurable and are treated primarily with chemotherapy according to symptoms. 相似文献
996.
The development of therapeutic monoclonal antibodies had been a significant advance in the treatment of B-cell non-Hodgkin's lymphoma (NHL). In the setting of blood and marrow transplantation (BMT), initial research was focused on in vitro graft purging. More recently, investigators have designed in vivo purging protocols using rituximab with the goal of obtaining tumor-free grafts. Exciting developments stem from the use of iodine 131 ((131)I)-tositumomab as well as yttrium 90 ((90)Y)-ibritumomab in myeloablative doses in blood and marrow transplantation protocols for high-risk patients. Finally, vigilance towards complications in particular unusual infections is advised given the profound immunosupressive state caused by these antibodies. 相似文献
997.
998.
999.
Horlocker TT Bajwa ZH Ashraf Z Khan S Wilson JL Sami N Peeters-Asdourian C Powers CA Schroeder DR Decker PA Warfield CA 《Anesthesia and analgesia》2002,95(6):1691-7, table of contents
We prospectively studied 1035 individuals undergoing 1214 epidural steroid injections to determine the risk of hemorrhagic complications. A history of bruising or bleeding was present in 176 (15%) patients. A platelet count was assessed in 77 patients before the epidural steroid injection; none was less than 100 x 10(9)/L. Nonsteroidal antiinflammatory drugs (NSAIDs) were reported by 383 (32%) patients, including 34 patients on multiple medications. Aspirin was the most common NSAID and was noted by 158 patients, including 104 patients on 325 mg or less per day. There were no spinal hematomas (major hemorrhagic complications). Blood was noted during needle or catheter placement in 63 (5.2%) patients (minor hemorrhagic complications). NSAIDs did not increase the frequency of minor hemorrhagic complications. However, increased age, needle gauge, needle approach, needle insertion at multiple interspaces, number of needle passes, volume of injectant, and accidental dural puncture were all significant risk factors for minor hemorrhagic complications. There were 42 patients with new neurologic symptoms or worsening of preexisting complaints that persisted more than 24 h after injection; median duration of the symptoms was 3 days (range, 1-20 days). Our results confirm those of previous studies performed in obstetric and surgical populations that document the safety of neuraxial techniques in patients receiving NSAIDs. We conclude that epidural steroid injection is safe in patients receiving aspirin-like antiplatelet medications. Minor worsening of neurologic function may occur after epidural steroid injection and must be differentiated from etiologies requiring intervention. IMPLICATIONS: Previous studies performed in obstetric and surgical populations have demonstrated that antiplatelet therapy does not increase the risk of spinal hematoma associated with spinal or epidural anesthesia and analgesia. We confirm the safety of epidural steroid injection in patients receiving aspirin-like medications. 相似文献
1000.
A localized Gleason score 6 (3 + 3) prostate cancer was found in a 56-year-old man with bilateral cryptorchidism. Radical laparoscopic prostatectomy was performed. However, at the beginning of the procedure, a uterus, two fallopian tubes, and two intra-abdominal gonads were endoscopically identified. The müllerian rests were excised and the gonads biopsied. The histologic examination showed testicular tissue. The association of prostate cancer and persistent müllerian duct syndrome to our knowledge has not previously been reported. Prostate cancer is an androgen-dependent neoplasm, and patients with male pseudohermaphroditism have poor androgen production that should provide protection against it. 相似文献