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441.
Effects of cholera toxin on cochlear endolymph production: model for endolymphatic hydrops. 总被引:1,自引:0,他引:1 下载免费PDF全文
P S Roheim S W Brusilow 《Proceedings of the National Academy of Sciences of the United States of America》1976,73(5):1761-1764
To evaluate a possible role for adenylate cyclase [ATP pyrophosphate-lyase (cyclizing), EC 4.6.1.1] and adenosine 3':5'-cyclic monophosphate in the secretion of endolymph, we studied the effect of an intra-scala media injection of purified cholera toxin (an adenylate cyclase stimulant) on cochlear endolymph volume, endolymphatic potential, and endolymphatic Na and K concentrations. 相似文献
442.
王硕 《中国听力语言康复科学杂志》2008,(6):10-14
1背景 新生儿听力普遍筛查(universal neonatal hearing screening,UNHS)是早期发现听力损失的有效手段.一些发达国家,如美国,澳大利亚和英国等,已经或正在建立新生儿听力普遍筛查项目.有许多研究报道了开展该项目可能获得的效益[1~3],但是关于该项目在发展中国家可行性的报道却很少[4,5]. 相似文献
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446.
Randomized controlled study comparing the efficacy of rapid and slow withdrawal of antiepileptic drugs during long‐term video‐EEG monitoring 下载免费PDF全文
447.
Myra PS Leung BOptom Benjamin Thompson DPhil BSc Joanna Black PhD BOptom BSc Shuan Dai FRANZCO Jane M Alsweiler PhD FRACP MBChB 《Clinical & experimental optometry》2018,101(1):4-12
Children born very preterm are at a greater risk of abnormal visual and neurological development when compared to children born at full term. Preterm birth is associated with retinopathy of prematurity (a proliferative retinal vascular disease) and can also affect the development of brain structures associated with post‐retinal processing of visual information. Visual deficits common in children born preterm, such as reduced visual acuity, strabismus, abnormal stereopsis and refractive error, are likely to be detected through childhood vision screening programs, ophthalmological follow‐up or optometric care. However, routine screening may not detect other vision problems, such as reduced visual fields, impaired contrast sensitivity and deficits in cortical visual processing, that may occur in children born preterm. For example, visual functions associated with the dorsal visual processing stream, such as global motion perception and visuomotor integration, may be impaired by preterm birth. These impairments can continue into adolescence and adulthood and may contribute to the difficulties in learning (particularly reading and mathematics), attention, behaviour and cognition that some children born preterm experience. Improvements in understanding the mechanisms by which preterm birth affects vision will inform future screening and interventions for children born preterm. 相似文献
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449.
Mutations in the sulonylurea receptor gene are associated with familial hyperinsulinism in Ashkenazi Jews 总被引:10,自引:1,他引:10
Nestorowicz A; Wilson BA; Schoor KP; Inoue H; Glaser B; Landau H; Stanley CA; Thornton PS; Clement JP th; Bryan J; Aguilar-Bryan L; Permutt MA 《Human molecular genetics》1996,5(11):1813-1822
Familial hyperinsulinism (HI) is a disorder of pancreatic beta-cell
function characterized by persistent hyperinsulinism despite severe
hypoglycemia. To define the molecular genetic basis of HI in Ashkenazi
Jews, 25 probands were screened for mutations in the sulfonylurea receptor
(SUR1) gene by single-strand conformation polymorphism (SSCP) analysis of
genomic DNA and subsequent nucleotide sequence analyses. Two common
mutations were identified: (I) a novel in-frame deletion of three
nucleotides (nt) in exon 34, resulting in deletion of the codon for F1388
(delta F1388) and (II) a previously described g-->a transition at
position-9 of the 3' splice site of intron 32 (designated 3992-9g-->a).
Together, these mutations are associated with 88% of the HI chromosomes of
the patients studied. 86Rb+ efflux measurements of COSm6 cells
co-expressing Kir6.2 and either wild-type or delta F1388 SUR1 revealed that
the F1388 mutation abolished ATP-sensitive potassium channel (KATP)
activity in intact cells. Extended haplotype analyses indicated that the
delta F1388 mutation was associated with a single specific haplotype
whereas the 3992-9g-->a mutation was primarily associated with a single
haplotype but also occurred in the context of several other different
haplotypes. These data suggest that HI in Ashkenazi Jews is predominantly
associated with mutations in the SUR1 gene and provide evidence for the
existence of at least two founder HI chromosomes in this population.
相似文献
450.
The mouse Y chromosome interval necessary for spermatogonial proliferation is gene dense with syntenic homology to the human AZFa region 总被引:9,自引:3,他引:9