全文获取类型
收费全文 | 33450篇 |
免费 | 2799篇 |
国内免费 | 102篇 |
专业分类
耳鼻咽喉 | 286篇 |
儿科学 | 1199篇 |
妇产科学 | 813篇 |
基础医学 | 4893篇 |
口腔科学 | 544篇 |
临床医学 | 3852篇 |
内科学 | 6883篇 |
皮肤病学 | 601篇 |
神经病学 | 3631篇 |
特种医学 | 854篇 |
外科学 | 3378篇 |
综合类 | 440篇 |
一般理论 | 57篇 |
预防医学 | 3524篇 |
眼科学 | 466篇 |
药学 | 2354篇 |
中国医学 | 47篇 |
肿瘤学 | 2529篇 |
出版年
2023年 | 241篇 |
2022年 | 437篇 |
2021年 | 856篇 |
2020年 | 601篇 |
2019年 | 884篇 |
2018年 | 918篇 |
2017年 | 716篇 |
2016年 | 765篇 |
2015年 | 855篇 |
2014年 | 1118篇 |
2013年 | 1511篇 |
2012年 | 2335篇 |
2011年 | 2349篇 |
2010年 | 1276篇 |
2009年 | 1082篇 |
2008年 | 1916篇 |
2007年 | 1994篇 |
2006年 | 1965篇 |
2005年 | 1834篇 |
2004年 | 1742篇 |
2003年 | 1565篇 |
2002年 | 1457篇 |
2001年 | 529篇 |
2000年 | 477篇 |
1999年 | 487篇 |
1998年 | 329篇 |
1997年 | 248篇 |
1996年 | 283篇 |
1995年 | 233篇 |
1994年 | 194篇 |
1993年 | 218篇 |
1992年 | 337篇 |
1991年 | 345篇 |
1990年 | 327篇 |
1989年 | 334篇 |
1988年 | 276篇 |
1987年 | 288篇 |
1986年 | 274篇 |
1985年 | 247篇 |
1984年 | 223篇 |
1983年 | 225篇 |
1982年 | 139篇 |
1981年 | 122篇 |
1980年 | 98篇 |
1979年 | 191篇 |
1978年 | 136篇 |
1977年 | 99篇 |
1976年 | 118篇 |
1974年 | 101篇 |
1972年 | 104篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
991.
992.
993.
Fabiano G. Nery Angela Miranda-Scippa Fabiana Nery-Fernandes Flavio Kapczinski Beny Lafer 《Comprehensive psychiatry》2014
Objectives
To investigate prevalence rates and clinical correlates of alcohol use disorders (AUD) among bipolar disorder (BD) patients in a large sample from the Brazilian Bipolar Research Network.Methods
Four hundred and eighty-three DSM-IV BD patients, divided according to the presence or absence of a lifetime AUD diagnosis (BD-AUD vs. BD-nonAUD), were included. Demographic and clinical characteristics of these two groups were compared. Logistic regression was performed to identify which characteristics were most strongly associated with a lifetime AUD diagnosis.Results
Nearly 23% presented a lifetime AUD diagnosis. BD-AUD patients were more likely to be male, to present rapid cycling, post-traumatic stress disorder (PTSD), anorexia, other substance use disorders (SUD), family history of SUD, any substance misuse during the first mood episode, history of psychosis, suicide attempts, and younger age at onset of illness than BD-nonAUD patients. Logistic regression showed that the variables most strongly associated with a lifetime AUD diagnosis were SUD (non-alcohol), any substance misuse during the first mood episode, PTSD, male gender, suicide attempt, family history of SUD, and younger age at onset of BD.Conclusions
BD-AUD patients begin their mood disorder earlier and present more suicidal behaviors than BD-nonAUD patients. Personal and family history of SUD may be good predictors of comorbid AUD among BD patients. These variables are easily assessed in the clinical setting and may help to identify a particularly severe subgroup of BD patients. 相似文献994.
Paul E. Jenkins Renee Rienecke Hoste Angela Celio Doyle Kamryn Eddy Ross D. Crosby Laura Hill Pauline Powers James E. Mitchell Daniel Le Grange 《Journal of psychosomatic research》2014
Objective
Health-related quality of life (HRQoL) is an emerging area of research in eating disorders (EDs) that has not been examined in adolescents in detail. The aim of the current study is to investigate HRQoL in an adolescent ED sample, examining the impact of ED symptoms on HRQoL.Methods
Sixty-seven treatment-seeking adolescents (57 females) with anorexia nervosa (AN), bulimia nervosa (BN), or eating disorder not otherwise specified (EDNOS) completed self-report measures of HRQoL and ED symptoms.Results
Participants reported poorer HRQoL in mental health domains than in physical health domains. Disordered attitudes, binge eating, and compensatory behaviors were associated with poorer mental health HRQoL, and body dissatisfaction was associated with poorer physical health HRQoL.Conclusion
The current study assessed HRQoL among adolescents with EDs, finding several consistencies with the literature on adults with EDs. Future research should compare adolescents and adults with EDs on HRQoL. 相似文献995.
Jeremy D. Robertson Pauline Higgins Jamie Price Scott Dunkley Giulio Barrese Julie Curtin 《Thrombosis research》2014
Introduction
It has been postulated that factor VIII (FVIII) products containing von Willebrand factor (VWF) may improve immune tolerance induction (ITI) success rate in patients with haemophilia A and poor prognostic factors.Materials and methods
We conducted a retrospective cohort analysis of a FVIII/VWF concentrate (BIOSTATE®) for ITI in paediatric patients with severe haemophilia A (SHA) and inhibitors, from January 2003 to December 2011 at 3 paediatric-only Haemophilia Treatment Centres in Australia. Response to ITI was assessed at or before 33 months and at completion of ITI. Fifteen male patients with SHA were included in the analysis.Results
BIOSTATE was used for primary ITI in 8 patients (2 years, range 1.1–11.5 years) and for salvage ITI in 7 patients (9.9 years, range 1.1–15.4). At the end of the observation period there were 11 patients who achieved a complete response with BIOSTATE after a median duration of 21 months (range 5–85 months); a partial response was achieved in 2 patients in whom ITI is ongoing. Therefore, the overall response rate was 86.6%. Two patients were deemed treatment failures: one due to non-compliance after 18 months of ITI and another in whom a partial response had not been achieved after 22 months of ITI.Conclusion
BIOSTATE was well-tolerated and effective when used for primary or salvage ITI in this cohort of paediatric patients with SHA and a high-level inhibitor. 相似文献996.
Ecological Momentary Assessment (EMA) may increase accuracy of data compared with retrospective questionnaires by assessing behaviours as they occur, hence decreasing recall biases and increasing ecological validity. This study examined the feasibility and concurrent validity of an EMA tool for adolescents with High-Functioning Autism Spectrum Disorders (HFASD). Thirty-one adolescents with HFASD completed a mobile phone EMA application that assessed stressors and coping for two weeks. Parents and adolescents also completed retrospective measures of the adolescent's coping/stressors. Moderate compliance with the EMA tool was achieved and some concurrent validity was established with the retrospective measure of coping. Concordance was found between the types of stressors reported by parents and adolescents but not the quantity. The results suggest adolescents with HFASD are capable of reporting on their stressors and coping via EMA. EMA has the potential to be a valuable research tool in this population. 相似文献
997.
998.
Rarely a new research area has gotten such an overwhelming amount of attention as have microRNAs. Although several basic questions regarding their biological principles still remain to be answered, many specific characteristics of microRNAs in combination with compelling therapeutic efficacy data and a clear involvement in human disease have triggered the biotechnology community to start exploring the possibilities of viewing microRNAs as therapeutic entities. This review serves to provide some general insight into some of the current microRNAs targets, how one goes from the initial bench discovery to actually developing a therapeutically useful modality, and will briefly summarize the current patent landscape and the companies that have started to explore microRNAs as the next drug target. 相似文献
999.
1000.
Akao H Polisecki E Kajinami K Trompet S Robertson M Ford I Jukema JW de Craen AJ Westendorp RG Shepherd J Packard C Buckley BM Schaefer EJ 《Atherosclerosis》2012,220(2):413-417
Our goal was to determine whether genetic variation at genes affecting statin metabolism or targets of statin therapy would influence low density lipoprotein (LDL) cholesterol lowering with pravastatin, baseline heart disease, or cardiac endpoints on trial. We examined associations of single nucleotide polymorphisms (SNPs) at the liver X receptor alpha (LXRA, rs12221497), and the solute carrier organic anion transporter (SLCO1B1, rs4149056 and rs2306283) gene loci with these variables. We studied 5411 participants in PROSPER (PROspective Study of Pravastatin in the Elderly at Risk) (mean age 75.3 years), who had been randomized to pravastatin 40 mg/day or placebo and were followed for a mean of 3.2 years. No relationships between genetic variation at the LXRA gene locus with statin induced LDL lowering response or other parameters were noted. Both the SLCO1B1 rs4149056 (valine for alanine at 174) and the rs2306283 (asparagine for aspartic acid at 130) SNPs affect the amino acid sequence of the SLCO1B1 gene product. No effect of the rs2306283 SNP on any of the variables was noted. However the presence of the rs4149056 SNP was associated with significantly less LDL cholesterol lowering response to pravastatin (wildtype, 71.5% of the population, -37.0%; heterozygotes, 25.8% of the population, -36.0%; and homozygotes, 2.7% of the population, -31.8%, p=0.003 at 6 months, and p=0.022 at 12 months). Our data indicate that the presence of the rs4149056 non-synonymous SNP at the SLCO1B1 gene locus can significantly decrease the pravastatin induced LDL cholesterol lowering response. 相似文献