全文获取类型
收费全文 | 110篇 |
免费 | 0篇 |
专业分类
儿科学 | 3篇 |
基础医学 | 4篇 |
临床医学 | 4篇 |
内科学 | 16篇 |
皮肤病学 | 3篇 |
神经病学 | 5篇 |
特种医学 | 4篇 |
外科学 | 59篇 |
综合类 | 1篇 |
预防医学 | 7篇 |
药学 | 1篇 |
肿瘤学 | 3篇 |
出版年
2022年 | 2篇 |
2021年 | 1篇 |
2020年 | 2篇 |
2019年 | 1篇 |
2018年 | 2篇 |
2017年 | 2篇 |
2016年 | 1篇 |
2015年 | 3篇 |
2014年 | 7篇 |
2013年 | 4篇 |
2012年 | 8篇 |
2011年 | 9篇 |
2010年 | 9篇 |
2009年 | 6篇 |
2008年 | 10篇 |
2007年 | 9篇 |
2006年 | 4篇 |
2005年 | 7篇 |
2004年 | 2篇 |
2003年 | 2篇 |
2002年 | 1篇 |
2001年 | 1篇 |
2000年 | 1篇 |
1999年 | 1篇 |
1991年 | 1篇 |
1990年 | 1篇 |
1989年 | 1篇 |
1988年 | 1篇 |
1985年 | 1篇 |
1984年 | 1篇 |
1978年 | 1篇 |
1975年 | 2篇 |
1973年 | 1篇 |
1972年 | 1篇 |
1969年 | 1篇 |
1938年 | 1篇 |
1926年 | 2篇 |
排序方式: 共有110条查询结果,搜索用时 15 毫秒
71.
F. Georgi H. Mysliwiec W. Welke 《European archives of psychiatry and clinical neuroscience》1926,78(1):383-392
Ohne ZusammenfassungErweitert nach einem in der Frühjahrstagung 1926 der Vereinigung südostdeutscher Psychiater und Neurologen gehaltenen Vortrag. 相似文献
72.
73.
74.
75.
76.
77.
78.
We report on a case of an isolated common iliac artery aneurysm infected by Candida albicans. To our knowledge, only one other case of this condition has been reported. The patient, a 49-year-old man with diabetes mellitus and a history of fungal urinary tract infections, had recurrent right knee pain and swelling. The knee effusion grew C albicans. Mild right hydronephrosis and a 4.6-cm aneurysm of the right common iliac artery without involvement of the aorta or iliac bifurcation was revealed by means of a computed tomography scan. The aneurysm wall was inflammatory, and there was associated purulence at the time of operation. The right ureter was densely adherent to the anterior aspect of the aneurysm, but could be palpated and dissected free because of a ureteral stent that was placed before the surgical incision. The aneurysm was resected, and the proximal and distal margins were oversewn without graft placement. C albicans was found in the resected aneurysm. The patient recovered without limb-threatening ischemia or claudication, but the distance he could walk remained limited because of right knee symptoms. The aneurysm may have formed by direct extension of infection from the right ureter or by hematogenous or lymphatic spread. This case raises interesting issues about operative strategies and etiology. 相似文献
79.
80.
Anna-Maria Bubolz Stephanie E. Weissinger Albrecht Stenzinger Annette Arndt Konrad Steinestel Silke Brüderlein Holger Cario Anneli Lubatschofski Claudia Welke Ioannis Anagnostopoulos Thomas F. E. Barth Ambros J. Beer Peter M?ller Martin Gottstein Andreas Viardot Jochen K. Lennerz 《Oncotarget》2014,5(12):4060-4070
For a growing number of tumors the BRAF V600E mutation carries therapeutic relevance. In histiocytic proliferations the distribution of BRAF mutations and their relevance has not been clarified. Here we present a retrospective genotyping study and a prospective observational study of a patient treated with a BRAF inhibitor.Genotyping of 69 histiocytic lesions revealed that 23/48 Langerhans cell lesions were BRAF-V600E-mutant whereas all non-Langerhans cell lesions (including dendritic cell sarcoma, juvenile xanthogranuloma, Rosai-Dorfman disease, and granular cell tumor) were wild-type. A metareview of 29 publications showed an overall mutation frequency of 48.5%; and with N=653 samples, this frequency is well defined. The BRAF mutation status cannot be predicted based on clinical parameters and outcome analysis showed no difference. Genotyping identified a 45 year-old woman with an aggressive and treatment-refractory, ultrastructurally confirmed systemic BRAF-mutant LCH. Prior treatments included glucocorticoid/vinblastine and cladribine-monotherapy. Treatment with vemurafenib over 3 months resulted in a dramatic metabolic response by FDG-PET and stable radiographic disease; the patient experienced progression after 6 months.In conclusion, BRAF mutations in histiocytic proliferations are restricted to lesions of the Langerhans-cell type. While for most LCH-patients efficient therapies are available, patients with BRAF mutations may benefit from the BRAF inhibitor vemurafenib. 相似文献