Naoki Higashida: The Reason I Jump

Journal of Autism and Developmental Disorders - This is a book review of the world famous “The reason I jump”, written by an autistic adolescent from Japan. In this book he is putting...     

No association between perceived exertion and session duration with hamstring injury occurrence in professional football

Training and competition loads have emerged as modifiable composite risk factors of non-contact injury. Hamstring strains are the most common injuries in football with substantial burden on the individual player and club. Nevertheless, robust evidence of a consistent load-hamstring injury relationship in professional football is lacking. Using available data from the Qatar Stars League over three competitive seasons, this study investigated the separate and combined effects of perceived exertion and session duration on hamstring injury occurrence in a sample of 30 outfield football players. Load variables were calculated into 7-day, 14-day, 21-day, 28-day periods of data, and week-to-week changes for average ratings of perceived exertion (RPE; au) score and session-RPE (s-RPE; session-duration  score), plus the cumulative training and match minutes and s-RPE, respectively. Conditional logistic regression models estimated load-injury relationships per 2-within-subject standard deviation increments in each candidate variable. Associations were declared practically important based on the location of the confidence interval in relation to thresholds of 0.90 and 1.11 defining small beneficial and harmful effects, respectively. The uncertainty for the corrected odds ratios show that typically high within-subject increments in each candidate variable were not practically important for training- and match-related hamstring injury (95% confidence intervals range: 0.85 to 1.16). We found limited exploratory evidence regarding the value of perceived exertion and session duration as etiological factors of hamstring injury in Middle-East professional football. Monitoring remains valuable to inform player load management strategies, but our exploratory findings suggest its role for type-specific injury risk determination appears empirically unsupported.     

Suppressive Effect on Lymphoproliferation In Vitro by Soluble Annexin II Released from Isolated Placental Membranes

PROBLEM: Syncytiotrophoblast microvillous plasma membranes (StMPM) are potent suppressors of lymphoproliferation in vitro. We have previously shown that soluble annexin II (AII) is present at higher levels in retroplacental serum (RPS) than in peripheral serum, and that soluble AII has an immunosuppressive effect. The aims of this study were to determine whether AII can be released from StMPM and whether soluble AII from StMPM exerts any immunosuppressive effect. METHOD OF STUDY: Isolated StMPM were incubated in growth medium for 18 hr and supernatants were prepared by ultracentrifugation. Soluble AII was detected by immunoblotting. StMPM, StMPM supernatant, and affinity-purified AII were analysed in a lymphoproliferation assay for immunomodulating activity. RESULTS: AII heavy chain and its p11 light chain were detected both in StMPM supernatant and in RPS after removal of StMPM particles by ultracentrifugation. StMPM, StMPM supernatant, and purified AII suppressed lymphoproliferation in a dose-dependent manner. Absorption of AII from StMPM supernatant reduced the suppressive activity. The suppressive effect of StMPM supernatant and purified AII was completely reversed by heating at 100°C for 30 min or by adding recombinant interleukin-2 at 100 units/ml. Although StMPM and affinity-purified AII suppressed the proliferation of lymphocytes from all donors tested, StMPM supernatant suppressed the proliferation of lymphocytes from 12 of 23 donors. Six of eight female non-suppressed donors were multiparae, whereas five of five female suppressed donors were nulliparae. CONCLUSIONS: Annexin II is released by isolated placental membranes in vitro and is present in RPS, indicating in vivo release of AII at the fetomaternal interface, probably as AII heterotetramer. AII has immunosuppressive activity and may be important in fetal allograft survival.     

Fc receptor for IgG (FcR) on rat microglia

Receptor for IgG (FcR) was demonstrated on rat microglia in vivo and in vitro by immunohistochemical staining with immune complexes of horseradish peroxidase (HRP) and rabbit IgG anti-HRP. Astrocytes, oligodendrocytes and neurons did not express FcR. Microglia in culture also showed FcR-mediated agglutination and phagocytosis of IgG-sensitized erythrocytes. A radiolabelled cDNA probe for rat FcRIII hybridized with a 1.4-kb RNA band in Northern blots prepared from total RNA from rat brain. FcRIII mRNA-positive cells in rat brain, presumably microglia, were demonstrated by in situ hybridization. FcR participates in the initiation of cytotoxic responses and of phagocytosis by microglia and is therefore likely to be important in mediating immune reactions in the brain.     

Cyclo-oxygenase- and capsaicin-sensitive afferent fibres affect Beta-adrenoceptor-evoked response in the rat urinary bladder.

As reported previously, the beta-adrenoceptor-evoked response in the in vitro rabbit detrusor is inhibited by non-steroidal anti-inflammatory drugs (NSAIDs). Prostaglandins can restore this response. This study was designed to better define physiological influences on beta-adrenoceptors in the urinary bladder and to ascertain whether the observations made in the rabbit urinary bladder in vitro were valid in vivo, as well as in a different animal species, i.e. in the rat. The NSAID indometacin partially inhibited the isoproterenol-evoked response in the rat detrusor muscle. When the neurokinin A (NKA) antagonist MEN-10376 was administered after indometacin, the beta-adrenoceptor-evoked response was completely abolished. The isoproterenol-evoked beta response was dose dependently reduced following treatment with the capsaicin antagonist ruthenium red. Taken together, these data indicate an involvement of prostanoids, NKA- and capsaicin-sensitive fibres in the beta-adrenoceptor-evoked response in the rat urinary bladder.     

Three-year results after radiotherapy for locally advanced sinonasal adenoid cystic carcinoma,using highly conformational radiotherapy techniques proton therapy and/or Tomotherapy

Purpose

We report the patient outcomes of a treatment combining proton therapy and Tomotherapy in sinonasal adenoid cystic carcinoma involving skull base.

Protontherapy of head and neck paragangliomas: A monocentric study

Purpose

The aim of this study was to assess efficacy and safety of proton beam therapy of paragangliomas of the head and neck, rare benign tumours developed close to crucial structures such as cranial nerves and vascular tissues.