全文获取类型
收费全文 | 713篇 |
免费 | 58篇 |
国内免费 | 3篇 |
专业分类
耳鼻咽喉 | 18篇 |
儿科学 | 19篇 |
妇产科学 | 7篇 |
基础医学 | 73篇 |
口腔科学 | 7篇 |
临床医学 | 69篇 |
内科学 | 178篇 |
皮肤病学 | 6篇 |
神经病学 | 33篇 |
特种医学 | 39篇 |
外科学 | 152篇 |
综合类 | 14篇 |
预防医学 | 36篇 |
眼科学 | 30篇 |
药学 | 47篇 |
中国医学 | 3篇 |
肿瘤学 | 43篇 |
出版年
2023年 | 11篇 |
2022年 | 22篇 |
2021年 | 31篇 |
2020年 | 36篇 |
2019年 | 45篇 |
2018年 | 37篇 |
2017年 | 20篇 |
2016年 | 18篇 |
2015年 | 36篇 |
2014年 | 33篇 |
2013年 | 33篇 |
2012年 | 64篇 |
2011年 | 59篇 |
2010年 | 51篇 |
2009年 | 37篇 |
2008年 | 40篇 |
2007年 | 48篇 |
2006年 | 37篇 |
2005年 | 18篇 |
2004年 | 24篇 |
2003年 | 33篇 |
2002年 | 16篇 |
2001年 | 1篇 |
2000年 | 4篇 |
1999年 | 5篇 |
1998年 | 6篇 |
1997年 | 2篇 |
1995年 | 1篇 |
1992年 | 3篇 |
1980年 | 2篇 |
1973年 | 1篇 |
排序方式: 共有774条查询结果,搜索用时 15 毫秒
101.
Manji RA Grocott HP Leake J Ariano RE Manji JS Menkis AH Jacobsohn E 《Journal canadien d'anesthésie》2012,59(1):6-13
Background
Seizures after cardiac surgery are a serious complication. The antifibrinolytic agent tranexamic acid (TA), which has known proconvulsant properties, may be associated with postoperative seizures. We sought to determine the association between TA and other risk factors for seizures after cardiac surgery.Methods and results
We analyzed a database of consecutive cardiac surgery patients (April 2003 to December 2009) using multivariable logistic regression analysis to assess for seizure risk factors. Seizures occurred in 56 of 5,958 patients (0.94%). TA use was associated with an increased risk of seizures (odds ratio 7.4, 95% confidence interval 2.8?C19.3; P?0.001). Multivariable logistic regression analysis revealed that the following factors were significantly associated with seizures: TA exposure; Acute Physiology, Age, and Chronic Health Evaluation (APACHE) II score?>?20; preoperative cardiac arrest; preoperative neurological disease; open chamber surgery; cardiopulmonary bypass time?>?150?min; and previous cardiac surgery. Seizures occurred at a median of 5.3 hr (interquartile range 2.4?C15.1 hr) after the end of surgery. In all, 58.1% were grand mal, 14.5% were associated with a stroke, and 58.1% recurred in hospital. Altogether, 48.3% of the patients were able to discontinue anticonvulsant medications prior to discharge. Compared to the non-seizure group, seizure patients had an increased rate of postoperative neurological complications, defined as delirium and/or stroke (3.2% vs 19.6%, P?0.001), increased intensive care unit (ICU) length of stay (1.0 vs 4.7?days, P?<?0.001), and increased ICU mortality (1.4 % vs 9.7 %, P?=?0.001).Conclusions
Our data suggest that multiple risk factors, including TA, are associated with seizures after cardiac surgery. Thus, the TA dose may be a readily modifiable risk factor for postoperative seizures. 相似文献102.
Christian Beetz Nicole Koch Mukhran Khundadze Geraldine Zimmer Sandor Nietzsche Nicole Hertel Antje-Kathrin Huebner Rizwan Mumtaz Michaela Schweizer Elisabeth Dirren Kathrin N. Karle Andrey Irintchev Victoria Alvarez Christoph Redies Martin Westermann Ingo Kurth Thomas Deufel Michael M. Kessels Britta Qualmann Christian A. Hübner 《The Journal of clinical investigation》2014,124(6):2809
103.
Rizwan Ahmad Deepti S Vikram Sergey Petryakov Yuanmu Deng Jay L Zweier Periannan Kuppusamy Bradley Clymer 《Magnetic resonance in medicine》2006,56(3):644-653
Fast and reliable data acquisition is a major requirement for successful and useful biological electron paramagnetic resonance imaging (EPRI) experiments. Even a technologically advanced and professionally supervised EPRI system can exhibit instabilities initiated by perturbations such as animal motion, microphonics, and temperature changes. As a result, part of an acquired data set may become corrupted with excessive noise and distortions, which in turn may degrade the quality of the reconstructed image. In this work an automated scheme to monitor the system performance and stability over the course of an experiment is demonstrated. This method ensures that the quality of the acquired data is maintained during the experiment. For this purpose, four parameters including noise content and integration of each acquired projection are quantified and measured against those of the zero-gradient (ZG) projection, which is set as a quality benchmark. Projections with parameter values that differ substantially from the expected values are identified as damaged and consequently are reacquired. Therefore, the proposed technique not only effectively monitors the quality of acquisition, it also saves a substantial amount of acquisition time because it eliminates the necessity of repeating the entire experiment in cases in which only a small fraction of the data are corrupted. 相似文献
104.
The appearance of the endothelial pavement pattern was studied in the pulmonary trunk, pulmonary veins, aorta, and inferior vena cava of the rat by means of silver staining of the cell borders. The endothelial cell in each of the four blood vessels was found to have its own distinctive shape, fusiform and pointed in the direction of blood flow in the case of the aorta and larger and more rectangular in the pulmonary trunk and pulmonary veins. Detailed quantitation of the dimensions and surface area of the endothelial cells in each blood vessel was carried out by a photographic technique. Pulmonary hypertension was induced in one group of rats by feeding them on Crotalaria spectabilis seeds. The endothelial pavement pattern in their pulmonary trunks became disrupted with many of the cells assuming a fusiform shape reminiscent of aortic endothelium. Many small, new endothelial cells formed in the pulmonary trunk suggesting division of cells to line the enlarging blood vessels. In contrast the endothelial cells of the inferior vena cava merely increased in size to cope with the dilatation of this vein. 相似文献
105.
106.
Burki T Hamid R Duffy P Ransley P Wilcox D Mushtaq I 《The Journal of urology》2006,176(3):1138-41; discussion 1141-2
PURPOSE: The aim of this study was to determine whether redo bladder neck reconstruction is effective in achieving continence after a failed bladder neck reconstruction procedure. MATERIALS AND METHODS: We retrospectively reviewed the hospital records of patients with bladder exstrophy who had undergone redo bladder neck reconstruction. There were 30 patients in the study, including 20 boys and 10 girls. Mean patient age at redo bladder neck reconstruction was 9.3 years (range 3.2 to 15.5). The patients were divided into 3 groups on the basis of the preoperative pattern of incontinence--incomplete wetters, complete wetters and those on continuous suprapubic drainage. Of the patients 15 already had undergone bladder augmentation, 12 had undergone a Mitrofanoff procedure and 12 had been treated with bulking agents injected in the bladder neck in an attempt to achieve continence. Four patients had undergone more than 1 bladder neck procedure. The patients were investigated with a combination of noninvasive urodynamics, cystoscopy, cystogram and ultrasound. All patients underwent Mitchell's modification of Young-Dees-Leadbetter bladder neck reconstruction. Additional procedures performed included augmentation cystoplasty and Mitrofanoff formation. RESULTS: Mean followup was 6.9 years (range 1.2 to 15.5). Postoperatively 28 patients were using clean intermittent catheterization to empty the bladder (5 per urethra, 23 via Mitrofanoff). Two patients remained on continuous suprapubic catheter drainage. A total of 18 patients (60%) were dry postoperatively (80% of girls and 50% of boys). Among dry patients only 3 were performing clean intermittent catheterization per urethra and 15 via a Mitrofanoff channel. No patient was able to void per urethra without the need for clean intermittent catheterization. The 2 patients on continuous suprapubic catheter drainage continued to remain so. At night only 50% of the patients were dry (5 on free drainage, 4 on clean intermittent catheterization, 6 not on any drainage). Those patients who did not respond satisfactorily to redo bladder neck reconstruction underwent subsequent additional procedures, which included injection of bulking agents (3 patients), insertion of an artificial urinary sphincter (1), Mitrofanoff formation (2) and bladder augmentation plus Mitrofanoff channel (1). Postoperative complications included difficulty with clean intermittent catheterization (8 patients), perivesical leak (1), recurrent epididymo-orchitis (1), upper urinary tract dilatation (2) and incisional hernia (1). Bladder neck closure was being considered in 5 patients. CONCLUSIONS: In our experience redo bladder neck reconstruction cannot achieve continence with volitional voiding per urethra. Although redo bladder neck reconstruction can render a significant number of patients dry, it is only effective if performed in conjunction with augmentation. Failure of the initial bladder neck reconstruction may be a reflection of a bladder that is of inadequate capacity and/or compliance. Therefore, bladder augmentation should be considered in all patients requiring redo bladder neck reconstruction. Bladder neck closure may be a better alternative to redo bladder neck reconstruction. 相似文献
107.
108.
Khan MR Raza SA Ahmad Z Naeem S Pervez S Siddiqui AA Ahmed M Azami R 《International journal of surgery (London, England)》2011,9(6):482-485
The gallbladder specimens of patients who underwent cholecystectomy for symptomatic gallstones between 2003 and 2005 were evaluated for the presence of Intestinal Metaplasia. (IM) and its risk factors. IM was positive in 39% of 293 patients tested, and in the comparative analysis of 114 metaplasia positive versus 179 negative patients, a high risk was found in patients who were 60 years or older [adjusted odds ratio (aOR) = 3.0, 95% confidence interval (CI): 1.5, 6.2]. Other factors with aOR greater than 1 were moderate to excessive use of chilies (1.8) and ethnic origin of North India (1.7). Screening method has yet to be devised for early detection of gallbladder cancer by identifying metaplastic lesions early in life. We believe that large geographic variation and lifestyle environmental factors associated with the development of gallbladder metaplasia and cancer mortality are concealed in our study that needs to be further explored. 相似文献
109.
Orbital cellulitis due to presumed gas-producing organisms has been associated with poor visual prognosis. We report successful visual recovery in a 14-year-old boy with orbital cellulitis and gas in the orbit on CT scan. The patient was treated with intravenous antibiotics and prompt orbital decompression. Pus from the sinus aspirate and orbital drain grew H. influenzae and Gram-negative bacilli. Repeat orbital surgery with drainage of residual abscess was performed and the patient made a complete recovery. 相似文献
110.
Apurba Sarker Apu Mahmuda Sultana Liza A.T.M. Jamaluddin Md. Amran Howlader Repon Kumer Saha Farhana Rizwan Nishat Nasrin 《Asian Pacific Journal of Tropical Biomedicine》2012,2(9):673-678