全文获取类型
收费全文 | 252篇 |
免费 | 11篇 |
专业分类
耳鼻咽喉 | 2篇 |
儿科学 | 12篇 |
妇产科学 | 12篇 |
基础医学 | 37篇 |
口腔科学 | 1篇 |
临床医学 | 34篇 |
内科学 | 38篇 |
皮肤病学 | 5篇 |
神经病学 | 24篇 |
特种医学 | 10篇 |
外科学 | 26篇 |
综合类 | 11篇 |
预防医学 | 19篇 |
眼科学 | 3篇 |
药学 | 17篇 |
肿瘤学 | 12篇 |
出版年
2022年 | 6篇 |
2021年 | 5篇 |
2020年 | 4篇 |
2019年 | 5篇 |
2018年 | 10篇 |
2017年 | 2篇 |
2016年 | 3篇 |
2015年 | 4篇 |
2014年 | 8篇 |
2013年 | 8篇 |
2012年 | 24篇 |
2011年 | 21篇 |
2010年 | 20篇 |
2009年 | 7篇 |
2008年 | 13篇 |
2007年 | 11篇 |
2006年 | 6篇 |
2005年 | 17篇 |
2004年 | 10篇 |
2003年 | 12篇 |
2002年 | 5篇 |
2000年 | 4篇 |
1998年 | 3篇 |
1993年 | 2篇 |
1992年 | 2篇 |
1991年 | 3篇 |
1990年 | 3篇 |
1989年 | 2篇 |
1988年 | 2篇 |
1986年 | 2篇 |
1983年 | 2篇 |
1979年 | 1篇 |
1978年 | 2篇 |
1977年 | 1篇 |
1976年 | 2篇 |
1975年 | 2篇 |
1974年 | 1篇 |
1972年 | 2篇 |
1971年 | 2篇 |
1970年 | 4篇 |
1969年 | 2篇 |
1968年 | 2篇 |
1967年 | 2篇 |
1963年 | 1篇 |
1962年 | 1篇 |
1961年 | 2篇 |
1954年 | 1篇 |
1948年 | 1篇 |
1928年 | 1篇 |
1926年 | 2篇 |
排序方式: 共有263条查询结果,搜索用时 15 毫秒
81.
This pilot study describes factors influencing rehabilitation in a community-based program for individuals with co-occurring psychiatric and substance abuse disorders. Findings indicate that individuals who had been in the program for more than six months had fewer absences and were more likely to adhere to program requirements. Psychiatric symptom relapse occurred in fewer than one-half of participants and was associated with program absence, medication nonadherence, substance abuse, and hospitalization. Family problems were associated with psychiatric symptom and substance abuse relapse as well as hospitalization. Findings suggest the need to identify specific reasons for nonadherence to treatment during the first six months of enrollment. Further study is needed to identify interventions to assist individuals with recovery early in the program, especially in regard to coping with family problems and psychiatric symptoms and substance abuse relapse. 相似文献
82.
The treatment of cervix cancer using high activity 60 Co sources 总被引:1,自引:0,他引:1
83.
Clinical differences between stable, chronic schizophrenic patients with long stays in the hospital and schizophrenic patients living in the community were investigated. Patients were matched for age, gender, and diagnosis. Hospitalized patients had more severe thought disorder and negative symptoms, and those in the community had a significantly higher incidence of depression and anxiety. The community-based patients were also receiving higher doses of neuroleptic drugs and had a higher incidence and severity of extra-pyramidal side effects. Results suggest that living in the community, despite its obvious benefits, may have its price in terms of the distressing effects of affective symptoms and neuroleptic side effects. 相似文献
84.
Joylee Fernandes Jayesh Mudgal Chamallamudi Mallikarjuna Rao Devinder Arora Sanchari Basu Mallik K. S. R. Pai 《Toxicology mechanisms and methods》2018,28(5):328-334
Neuroinflammation plays an important role in the pathophysiology of Alzheimer’s disease. Neurokinin substance P is a key mediator which modulates neuroinflammation through neurokinin receptor. Involvement of substance P in Alzheimer’s disease is still plausible and various controversies exist in this hypothesis. Preventing the deleterious effects of substance P using N-acetyl-L-tryptophan, a substance P antagonist could be a promising therapeutic strategy. This study was aimed to evaluate the effect of N-acetyl-L-tryptophan on aluminum induced spatial memory alterations in rats. Memory impairment was induced using aluminum chloride (AlCl3) at a dose of 10?mg/kg for 42 d. After induction of dementia, rats were exposed to 30 and 50?mg/kg of N-acetyl-L-tryptophan for 28 d. Spatial memory alterations were measured using Morris water maze. Acetylcholinesterase activity and antioxidant enzyme glutathione level were assessed in hippocampus, frontal cortex and striatum. The higher dose of N-acetyl-L-tryptophan (50?mg/kg) significantly improved the aluminum induced memory alterations. N-acetyl-L-tryptophan exposure resulted in significant increase in acetylcholinesterase activity and glutathione level in hippocampus. The neuroprotective effect of N-acetyl-L-tryptophan could be due to its ability to block substance P mediated neuroinflammation, reduction in oxidative stress and anti-apoptotic properties. To conclude, N-acetyl-L-tryptophan may be considered as a novel neuroprotective therapy in Alzheimer’s disease. 相似文献
85.
P. C. Modayil G. W. Lloyd A. Mallik D. A. Bowdler 《European archives of oto-rhino-laryngology》2014,271(5):855-861
Audiovestibular sequelae of electrical injury, due to lightning or electric current, are probably much more common than indicated in literature. The aim of the study was to review the impact of electrical injury on the cochleovestibular system. Studies were identified through Medline, Embase, CINAHL and eMedicine databases. Medical Subject Headings used were ‘electrical injury’, ‘lightning’, ‘deafness’ and ‘vertigo’. All prospective and retrospective studies, case series and case reports of patients with cochlear or vestibular damage due to lightning or electrical current injury were included. Studies limited to external and middle ear injuries were excluded. Thirty-five articles met the inclusion criteria. Fifteen reported audiovestibular damage following electric current injury (domestic or industrial); a further 15 reported lightning injuries and five concerned pathophysiology and management. There were no histological studies of electrical current injury to the human audiovestibular system. The commonest acoustic insult after lightning injury is conductive hearing loss secondary to tympanic membrane rupture and the most frequent vestibular symptom is transient vertigo. Electrical current injuries predominantly cause pure sensorineural hearing loss and may significantly increase a patient’s lifetime risk of vertigo. Theories for cochleovestibular damage in electrical injury include disruption of inner ear anatomy, electrical conductance, hypoxia, vascular effects and stress response hypothesis. The pathophysiology of cochleovestibular damage following electrical injury is unresolved. The mechanism of injury following lightning strike is likely to be quite different from that following domestic or industrial electrical injury. The formulation of an audiovestibular management protocol for patients who have suffered electrical injuries and systematic reporting of all such events is recommended. 相似文献
86.
87.
88.
Siddhartha Laskar Chandrika Nair Suman Mallik Gaurav Bahl Suresh Pai Tanuja Shet Tejpal Gupta Brijesh Arora Ashish Bakshi C.S. Pramesh Rajesh Mistry Sajid Qureshi Seema Medhi Nirmala Jambhekar Purna Kurkure Shripad Banavali Mary Ann Muckaden 《International journal of radiation oncology, biology, physics》2011
89.
Katchy KC Mallik AA Al-Nashmi NM Joseph E Alexander S Al-Ramadan A 《Journal of neuro-oncology》2011,104(1):271-277
The dearth of literature on intracranial tumors (ICT) in Kuwait has necessitated this study whose objective is epidemiological.
It is based on the records of the Department of Pathology, Al-Sabah Hospital, Kuwait, where virtually all brain biopsies in
Kuwait were examined. Between 1995 and 2009, 439 males (53.41%) and 383 females (46.59%) had primary intracranial tumors (PICT).
Most (69%) were younger than 50 years, with 16% children and adolescents and 4% elderly (≥70 years); meningioma (28%), pituitary
adenoma (19%), glioblastoma (15%), astrocytoma (13%), and medulloblastoma (5%) were the most common. In childhood and adolescence,
astrocytoma (35.34%) and medulloblastoma (22.56%) predominated. The mean age-adjusted incidence rate/100,000 was: PICT: 3.02;
astrocytic tumors: 0.93; meningioma: 0.96; pituitary adenoma: 0.44; and medulloblastoma: 0.13. All showed a declining trend
which was only statistically significant for medulloblastoma (P = 0.007). A modest correlation between the percentage of elderly in the general population and incidence rates was found
(r = 0.411). Tumors with significant male preponderance were high-grade astrocytic tumors, silent pituitary adenoma (SA), and
nerve sheath tumor. Meningioma had a female to male ratio of 2.24. The peak frequency for functional pituitary adenoma and
females was in the age range of 20–29 years, while for SA and males it was 40–49 years. About 5% of ICT were metastatic, with
cancers of breast (26%), lung (17%) and gastrointestinal (11%) origin as the most common. In conclusion, the epidemiology
of PICT in Kuwait is characterized by low incidence rates and a distinct age distribution. 相似文献
90.
Myint NW Kaewkungwal J Singhasivanon P Chaisiri K Panjapiyakul P Siriwan P Mallik AK Nyein SL Mu TT 《Conflict and health》2011,5(1):9-11