Systemic protection by antioxidants against UVL-induced erythema

An antioxidant supplemented diet provided marked systemic protection against ultraviolet light mediated erythema in hairless mice. Among the individual constituents of the diet, butylated hydroxytoluene was most effective whereas glutathione and vitamins C and E afforded negligible protection. The mixture of antioxidants, and butylated hydroxytoluene individually, demonstrated diminished, but significant, protection when applied topically. The safety of this systemic photoprotectant and its clinical relevance at present is unknown.     

Endocardial fibroelastosis occurring in a mother and daughter

Endocardial fibroelastosis (EFE) in a mother and daughter are reported. This entity has a primary and secondary form. In this case, the 23-year-old mother died 11 months after delivery with findings of EFE. At age 3(1/2) years, the daughter was admitted in congestive heart failure and did not respond to medical management. The autopsy findings revealed EFE. Endocardial fibroelastosis in both mother and daughter is a very rare finding.     

Experimental autoimmune encephalomyelitis can be prevented and cured by infection with Trypanosoma cruzi

Trypanosoma cruzi is an intracellular parasite that induces a strong Th1-type response and immunosuppression during the acute phase of infection. To study how the infection with T. cruzi would modulate the development of an autoimmune disease, we immunized C57BL/6 mice and IL-10 or iNOS knock-out mice of the same background with the encephalitogenic MOG 35-55 peptide and infected them with T. cruzi. Our results demonstrate that infection with T. cruzi completely prevents EAE development and furthermore induces complete and lasting remission in mice that were infected with this parasite after they had developed clinical EAE. Nitric oxide and IL-10 participate in triggering the mechanisms associated with EAE suppression by the infection. Decreased lymphoproliferation and increased frequencies of Annexin-positive cells and of T cells bearing CD95, CD95L or CTLA-4 were observed in the spleen from immunized/infected mice, as well as lower IL-2 and increased TGF-beta production in comparison with only immunized mice. Our results indicate that several effector and regulatory mechanisms of the immune response that arise during the acute phase of T. cruzi infection lastingly affect the expansion and/or effector functions of encephalitogenic cells, preventing the onset or inducing complete remission of EAE.     

A locus for autosomal dominant anterior polar cataract on chromosome 17p

Inherited cataract is a clinically and genetically heterogeneous disease. Here we report the identification of a new locus for an autosomal dominant anterior polar cataract on the short arm of chromosome 17. To map this new locus we performed genetic linkage analysis with microsatellite markers in a four-generation pedigree. After exclusion of seven candidate loci for cataract, we obtained significant positive LOD scores for markers D17S849 (Z = 4.01 / theta = 0.05) and D17S796 (Z = 4.17 / theta = 0.05). Multipoint analysis gave a maximum LOD score of 5.2 (theta max = 0.06) between these two markers. From haplotype analysis, the cataract locus lies in the 13 cM interval between markers D17S849 and D17S796. This study provides the first genetic mapping of an autosomal dominant anterior polar cataract.      

The CTLA-4 gene region of chromosome 2q33 is linked to, and associated with, type 1 diabetes. Belgian Diabetes Registry

Susceptibility to autoimmune insulin-dependent (type 1) diabetes mellitus is determined by a combination of environmental and genetic factors, which include variation in MHC genes on chromosome 6p21 (IDDM1) and the insulin gene on chromosome 11p15 (IDDM2). However, linkage to IDDM1 and IDDM2 cannot explain the clustering of type 1 diabetes in families, and a role for other genes is inferred. In the present report we describe linkage and association of type 1 diabetes to the CTLA-4 gene (cytotoxic T lymphocyte associated-4) on chromosome 2q33 (designated IDDM12). CTLA-4 is a strong candidate gene for T cell- mediated autoimmune disease because it encodes a T cell receptor that mediates T cell apoptosis and is a vital negative regulator of T cell activation. In addition, we provide supporting evidence that CTLA-4 is associated with susceptibility to Graves' disease, another organ- specific autoimmune disease.      

The cost of moving with the left hand

Precise left-hand movements take longer than right-hand movements (for right-handers). To quantify how left-hand movements are affected by task difficulty and phase of movement control, we manipulated the difficulty of repetitive speeded aiming movements while participants used the left or right hand. We observed left-hand costs in both initial impulse and current control phases of movement. While left-hand cost during the initial impulse phase was small, left-hand cost during the current control phase varied from 10 to 60 ms, in direct proportion to the movement’s difficulty as quantified by Fitts’ law (0.77 < R ² < 0.99, across three experiments). In particular, in comparison with a difficult task for the right hand (Fitts’ ID_R = 6.6), the left hand’s task would have to be made easier by 0.5 bits (ID_L = 6.1) to be performed as quickly. The left-hand cost may reflect the time required for callosal transfer of information between the left and right hemispheres during the current control phase of precision left-hand movements or reflect movement control differences in the current control phase of movement that are inherent to the hemispheres. Overall, the present results support multiphase models of movement generation, in which separate specialized processes contribute to the launching and completion of precision hand movements.