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排序方式: 共有1354条查询结果,搜索用时 15 毫秒
11.
Hiroyuki Hisada Yoshiki Sakaguchi Kaori Oshio Satoru Mizutani Hideki Nakagawa Junichi Sato Dai Kubota Miho Obata Rina Cho Sayaka Nagao Yuko Miura Hiroya Mizutani Daisuke Ohki Seiichi Yakabi Yu Takahashi Naomi Kakushima Yosuke Tsuji Nobutake Yamamichi Mitsuhiro Fujishiro 《Current oncology (Toronto, Ont.)》2022,29(7):4678
Although the mortality rates of gastric cancer (GC) are gradually declining, gastric cancer is still the fourth leading cause of cancer-related death worldwide. This may be due to the high rate of patients who are diagnosed with GC at advanced stages. However, in countries such as Japan with endoscopic screening systems, more than half of GCs are discovered at an early stage, enabling endoscopic resection (ER). Especially after the introduction of endoscopic submucosal dissection (ESD) in Japan around 2000, a high en bloc resection rate allowing pathological assessment of margin and depth has become possible. While ER is a diagnostic method of treatment and may not always be curative, it is widely accepted as standard treatment because it is less invasive than surgery and can provide an accurate diagnosis for deciding whether additional surgery is necessary. The curability of ER is currently assessed by the completeness of primary tumor removal and the possibility of lymph node metastasis. This review introduces methods, indications, and curability criteria for ER of EGC. Despite recent advances, several problems remain unsolved. This review will also outline the latest evidence concerning future issues. 相似文献
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Masaru Tanioka Tsugumi Ebihana Manae Uraguchi Haruka Shoji Yuka Nakamura Rina Ueda Shota Ogura Yoshifumi Wakiya Tohru Obata Takahiro Ida Jun Horigome Shinichiro Kamino 《RSC advances》2022,12(32):20714
The fluorescence spectral fingerprint, also known as the excitation-emission matrix (EEM), is used to assess and visualize therapeutic drug photodegradation in combination with chemometrics. Examination of EEM-parallel factor analysis (PARAFAC) data showed that an individual component was easily separated from a mixture of photogenerated products of a heterocyclic pharmacophore, in this case, phenothiazine drugs (PTZs). Detailed investigations of both structure–EEM relationships and kinetics revealed that the components extracted from EEM–PARAFAC could be quantitatively attributed to such photogenerated products as phenothiazine sulfoxide and carbazole derivatives. EEM in combination with principal component analysis (PCA) could be used as a mapping tool to visualize information of the photodegradation process of PTZs. We also assessed the photostability of various types of PTZs containing side chains by using validated EEM–PARAFAC methodology.Drug quality and assurance changes with time under the influence of a variety of environmental factors, such as light, temperature, and moisture. 相似文献
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Atrial overdrive pacing during wide QRS tachycardia with RBBB morphology. What is the mechanism? 下载免费PDF全文
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Maiti PK Bose R Bandyopadhyay S Bhattacharya S Dey JB Ray A 《Indian journal of pathology & microbiology》2004,47(2):295-297
Subcutaneous mycoses caused by the family Entomophthoraceae is very rare type of disease and is being reported sporadically from various Tropical countries including India. Here we report 8 cases of rhinoentomophthoromycosis caused by Conidiobolous coronatus and 7 cases of chronic subcutaneous phycomycosis caused by Basidiobolus ranarum. Cases were detected during a span of 9 years between 1991 to 1999, from 9 districts in and around Kolkata (Eastern India). Former type of lesions were detected among 20 to 65 age group of healthy individuals, predominantly males (7:1). In the latter type, male-female ratio was 2:5, and except for one all cases belonged to below 20 years age group of healthy individuals. Several cases were detected only after examination of repeat biopsy samples. With high degree of clinical suspicion, right approach is needed for laboratory confirmation of diagnosis. 相似文献
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Tomato immune receptor Ve1 recognizes effector of multiple fungal pathogens uncovered by genome and RNA sequencing 总被引:5,自引:0,他引:5
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Masayuki Tokuda Wen Chen Thonthi Karunakaran Howard K. Kuramitsu 《Infection and immunity》1998,66(11):5232-5237
20.
Hisada Hiroyuki Tsuji Yosuke Obata Miho Cho Rina Nagao Sayaka Miura Yuko Mizutani Hiroya Ohki Daisuke Yakabi Seiichi Takahashi Yu Sakaguchi Yoshiki Kakushima Naomi Yamamichi Nobutake Fujishiro Mitsuhiro 《Journal of gastroenterology》2022,57(12):952-961
Journal of Gastroenterology - Sarcopenia prevalence has increased in proportion to the aging population in Japan. We aimed to investigate the association between sarcopenia and clinical outcomes... 相似文献