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21.
Frank Kloprogge Rose McGready Aung Pyae Phyo Marcus J Rijken Warunee Hanpithakpon Hla Hla Than Nathar Hlaing Naw Thida Zin Nicholas P J Day Nicholas J White Fran?ois Nosten Joel Tarning 《British journal of clinical pharmacology》2015,80(4):642-653
Aim
The aim was to compare the pharmacokinetic properties of artesunate and dihydroartemisinin in the same women: i) pregnant with acute uncomplicated malaria on day 1 and 2, ii) pregnant with convalescent malaria on day 7 and iii) in a healthy state 3 months post-partum on day 1, 2 and 7.Methods
Non-linear mixed-effects modelling was used to compare plasma concentration–time profiles of artesunate and dihydroartemisinin over 7 days of treatment following oral and intravenous artesunate administration to pregnant women with uncomplicated Plasmodium falciparum malaria during their second or third trimesters of pregnancy. The same women were restudied 3 months after delivery when fully recovered. Non-compartmental results of the same study have been published previously.Results
Twenty pregnant patients on the Thailand-Myanmar border were studied and 15 volunteered to be restudied 3 months post-partum. Malaria and pregnancy had no effect on the pharmacokinetic properties of artesunate or dihydroartemisinin after intravenous artesunate administration. However, malaria and pregnancy had opposite effects on the absorption of orally administered artesunate. Malaria increased the absolute oral bioavailability of artesunate by 87%, presumably by inhibiting first pass effect, whereas pregnancy decreased oral bioavailability by 23%.Conclusions
The population pharmacokinetic analysis demonstrated opposite effects of malaria and pregnancy on the bioavailability of orally administered artesunate. Lower drug exposures during the second and third trimesters of pregnancy may contribute to lower cure rates and thus the development of drug resistance. Dose optimization studies are required for artesunate containing artemisinin-based combination therapies (ACTs) in later pregnancy. 相似文献22.
Cytogenetic and molecular analysis in Philadelphia negative CML 总被引:2,自引:0,他引:2
van der Plas DC; Hermans AB; Soekarman D; Smit EM; de Klein A; Smadja N; Alimena G; Goudsmit R; Grosveld G; Hagemeijer A 《Blood》1989,73(4):1038-1044
23.
Lurvink Robin J. Rijken Anouk Bakkers Checca Aarts Mieke J. Kunst Peter W. A. van de Borne Ben E. van Erning Felice N. de Hingh Ignace H. J. T. 《Clinical & experimental metastasis》2021,38(3):295-303
Clinical & Experimental Metastasis - Peritoneal metastases (PM) from lung cancer are rare and it is unknown how they affect the prognosis of patients with lung cancer. This population-based... 相似文献
24.
Fourteen consecutively referred, symptomatic patients with Waldenstrom's macroglobulinemia (ages 52-87 yr) have been treated with the 5-drug M-2 protocol (BCNU, cyclophosphamide, vincristine, melphalan, and prednisone). Three patients were previously treated and 11 patients were untreated. The majority of patients were symptomatic from hyperviscosity. All patients have responded to therapy. Two patients have achieved complete remissions and 12 patients partial remissions to date. None of the patients with symptomatic hyperviscosity has required plasmapheresis since therapy with the M-2 has been initiated. Lymphadenopathy, hepatosplenomegaly, and anemia have also responded to treatment. Follow-up data are limited, with survival from initiation of therapy with the M-2 ranging from 2+ to 35% mo (median 17+ mo) 2+-40+ mo from time of diagnosis). Combination chemotherapy for Waldenstrom's macroglobulinemia with the M-2 protocol appears to increase the response rate in patients with symptomatic disease. Further survival analysis will be carried out. 相似文献
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ME Boel MJ Rijken M Pimanpanarak NL Keereecharoen S Proux F Nosten R McGready 《The American journal of tropical medicine and hygiene》2012,87(3):447-449
Abstract. In a few small studies an association between blood group O and placental malaria has been described. The relationship between blood group and malaria in pregnancy (Plasmodium vivax and Plasmodium falciparum) was analyzed in 1,468 women from three longitudinal cohort studies in which weekly malaria screening was done systematically during pregnancy. One-third of women (447 of 1,468) had at least one malaria infection in pregnancy. The ABO blood group phenotype was not associated with the species of infection, frequency of malaria attacks, symptoms of malaria, hematocrit, or parasitemia during pregnancy. 相似文献
29.
DC Bosanquet CN Jones N Gill P Jarvis MH Lewis 《Annals of the Royal College of Surgeons of England》2013,95(1):15-19