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排序方式: 共有288条查询结果,搜索用时 22 毫秒
101.
Kaire Innos Vahur Valvere Peeter Padrik Evelyn Eelma Riina Kütner Jaak Lehtsaar 《Women & health》2013,53(2):129-140
ABSTRACTThe aim of this study was to examine past mammography use and mode of detection among breast cancer (BC) patients in Estonia, a country that has low screening coverage and high BC mortality. Women newly diagnosed with primary BC in Estonia in 2008–2010 were interviewed. Determinants of past mammography use and the detection of BC by mammography were studied using multivariate logistic regression. Among 977 participants, almost half reported no mammograms prior to the detection of BC. Overall, 22% of the cases were detected by mammography (16% by screening mammography). Detection by mammography was strongly related to age, past mammography use, and obesity. Among cases detected by mammography, 10% were stage III/IV at diagnosis (32% among cases detected by other modes). This study showed low mammography utilization and high rate of self-detection of BC in Estonia. Increased detection by mammography would help diagnose the disease at an earlier stage and consequently avoid premature BC deaths. Efforts should be undertaken to increase participation in screening and improve the availability of mammography among older and high-risk women. The results are likely to be relevant for other countries and population groups with low screening coverage. 相似文献
102.
Oksaharju A Kankainen M Kekkonen RA Lindstedt KA Kovanen PT Korpela R Miettinen M 《World journal of gastroenterology : WJG》2011,17(6):750-759
AIM:To investigate the effects of four probiotic bacteria and their combination on human mast cell gene expression using microarray analysis.METHODS:Human peripheral-blood-derived mast cells were stimulated with Lactobacillus rhamnosus (L.rhamnosus) GG (LGG),L.rhamnosus Lc705 (Lc705),Propionibacterium freudenreichii ssp.shermanii JS (PJS) and Bifidobacterium animalis ssp.lactis Bb12 (Bb12) and their combination for 3 or 24 h,and were subjected to global microarray analysis using an Affymetrix GeneChip Human... 相似文献
103.
Bowyer P Moore CB Rautemaa R Denning DW Richardson MD 《Current infectious disease reports》2011,13(6):485-491
Oral triazole therapy is well established for the treatment of invasive aspergillosis (IPA), allergic aspergillosis (ABPA), and chronic pulmonary aspergillosis (CPA), and is often long-term. Resistance to triazole azole antifungal drugs in Aspergillus fumigatus is now a major clinical problem in a number of European locations, in China, Canada and the USA with particularly high frequencies from the north-west of the UK, and The Netherlands. A number of centers are reporting the continuing increasing frequency and evolution of resistance mechanisms in A. fumigatus, in both azole-naïve and patients treated with azoles. The increasing rate of resistance is of concern. A number of resistance mechanisms have been found. The biofilm modality of Aspergillus growth may have a number of therapeutic implications for aspergillosis, including antifungal resistance. Microbiological diagnosis of aspergillosis is limited by poor culture yield, leading to uncertainty about the frequency of triazole resistance. Direct resistance testing in culture-negative clinical samples may add additional insights into the prevalence of azole resistance in A. fumigatus. 相似文献
104.
Puosi R Korkman M Sarajuuri A Jokinen E Mildh L Mattila I L?nnqvist T 《Journal of the International Neuropsychological Society》2011,17(6):1094-1103
Recent advances in the treatment of children with severe congenital heart defects, such as hypoplastic left heart syndrome (HLHS) and other forms of univentricular heart (UVH), have significantly improved their survival rates. However, these children are at risk for various neurodevelopmental deficits. The aim of the present study was to assess cognitive development, expressive language, and behavior in 30-month-old children with univentricular heart. The participants were 22 children with HLHS, 14 with UVH, and 41 healthy control subjects. The Bayley Scales of Infant Development II, MacArthur Communicative Development Inventories, and Child Behavior Checklist were used for assessments. The results revealed that children with HLHS exhibited a significantly lower mean mental development index, more delays in expressive language functions, and more behavioral problems than did the control children. Two children with HLHS (9%) had mental development indexes below 50, indicating significantly delayed performance. The children with UVH differed from the control children with respect to their lower mean mental development index. These findings suggest that at the age of 30 months, neurodevelopmental deficits are especially prevalent in children with HLHS. Thus, early developmental screening, intervention, and neuropsychological follow-up until school age is recommended particularly for the children with HLHS. 相似文献
105.
Patsalides A Santillan A Knopman J Tsiouris AJ Riina HA Gobin YP 《Journal of neurointerventional surgery》2011,3(1):80-84
Spinal dural arteriovenous fistulas (SDAVFs) represent the most frequent spinal arteriovenous malformation and have an ominous natural history if left untreated. In the present review, we describe the spinal vascular anatomy, pathophysiology and clinical manifestations of SDAVFs, and the current role of endovascular embolization in this type of lesion. 相似文献
106.
Rajappa P Krass J Riina HA Boockvar JA Greenfield JP 《Interventional neuroradiology》2011,17(4):459-465
Ependymoma is a central nervous system tumor associated with a poor prognosis due to limited efficacy of current medical treatment modalities, often resulting in multiple surgical re-resections with each tumor recurrence. As traditional chemotherapeutic regimens have proved unsuccessful in long-term control of subtotally resected ependymoma, other agents targeting the tumor microenvironement including the angiogenic factors supplying neovascularization have recently been used. Anti-angiogenic agents such as bevacizumab are routinely used in adult patients with recurrent glioma. Selective intra-arterial cerebral infusion (SIACI) of biological agents within tumor-supplying cerebral vasculature has recently been re-examined as a means to avoid the systemic side-effects associated with intravenous use of bevacizumab. This technical paper describes the first reported use of SIACI for delivery of two targeted biologic agents, bevacizumab and cetuximab in a pediatric patient utilizing the basilar artery to selectively administer the drugs to the tumor microenvironment. We believe this method for therapeutic delivery will both broaden treatment options and better refine treatment methodology as the multi-modality treatment approach often required to treat patients with pediatric ependymomas and other intracranial malignancies evolves. 相似文献
107.
Burkhardt JK Riina HA Shin BJ Moliterno JA Hofstetter CP Boockvar JA 《Interventional neuroradiology》2011,17(3):286-295
Intra-arterial (IA) chemotherapy for malignant gliomas including glioblastoma multiforme was initiated decades ago, with many preclinical and clinical studies having been performed since then. Although novel endovascular devices and techniques such as microcatheter or balloon assistance have been introduced into clinical practice, the question remains whether IA therapy is safe and superior to other drug delivery modalities such as intravenous (IV) or oral treatment regimens. This review focuses on IA delivery and surveys the available literature to assess the advantages and disadvantages of IA chemotherapy for treatment of malignant gliomas. In addition, we introduce our hypothesis of using IA delivery to selectively target cancer stem cells residing in the perivascular stem cell niche. 相似文献
108.
109.
Vadim Brjalin Riina Salupere Tatjana Tallo Tatiana Kuznetsova Ljudmilla Priimägi Valentina Tefanova 《Central European Journal of Medicine》2013,8(6):822-829
Background
The aim of the study was to analyse the predictive host and viral factors of sustained virological response (SVR) in Estonian patients with chronic hepatitis C genotype 1b.Methods
A total of 76 outpatients (44 males and 32 females, aged 21–63 years) were enrolled in the single-centre prospective study. The patients received 180 µg of Peg-IFN α-2α weekly plus daily weight-based ribavirin (1000–1200 mg/day).Results
The SVR was achieved in 50% of the patients, 43.4% of the patients were referred to as non-SVR. The SVR and the non-SVR patients differed significantly in terms of age (p=0.012), stage of fibrosis (p=0.012), grade of inflammatory activity (p=0.002), platelet count (p=0.005), gamma-glutamyltransferase (GGT) level (p=0.028), as well as a decrease of the viral load at weeks 4 and 12 more than 3.59 log10 IU/ml and 5.98 log10 IU/ml (P<0.01), respectively.Conclusion
Age below 40 years, absence of or mild and moderate fibrosis, absence of severe inflammation activity, normal platelet count and normal GGT level, and pronounced changes in viral kinetics at weeks 4 and 12, were valuable predictors of better response to peginterferon alfa plus ribavirin treatment in Estonian patients with chronic hepatitis C genotype 1b. 相似文献110.
Unilateral occlusion of the middle cerebral artery after varicella-zoster virus infection 总被引:3,自引:0,他引:3
We report a 4-year-old child who developed hemiplegia 6 months after varicella-zoster virus (VZV) infection. Cerebral angiography showed complete occlusion of the right middle cerebral artery with basal moyamoya vessels. Elevation of anti-VZV antibody in the cerebrospinal fluid indicated central nervous system involvement. The association between VZV cerebral angitis and unilateral occlusion of right middle cerebral artery is discussed. 相似文献