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61.
62.
Atas Nuh Çakır Bağdagül Bakır Fatih Uçar Murat Satış Hasan Güz Gizem Tuğçe Demirel Kübra Durmuş Babaoğlu Hakan Salman Reyhan Bilici Güler Aslıhan Avanoğlu Karadeniz Hazan Haznedaroğlu Şeminur Göker Berna Öztürk Mehmet Akif Tufan Abdurrahman 《Clinical rheumatology》2022,41(5):1381-1389
Clinical Rheumatology - Anti-tumor necrosis factor (anti-TNF) agents are commonly used in treatment of axial spondyloarthritis (axSpA), but clinical and radiological improvement is not achieved in... 相似文献
63.
mutevelızade Gozde Kocer Nazım Emrah Reyhan Mehmet 《Annals of nuclear medicine》2022,36(12):1050-1058
Annals of Nuclear Medicine - This study aimed to investigate immunohistochemical staining of sodium iodide symporter (NIS) and its effect on response to I-131 therapy in differentiated thyroid... 相似文献
64.
Mujde Akturk Metin Arslan Alev Altinova Aysegul Ozdemir Reyhan Ersoy Ilhan Yetkin Elif Ayvali Sevim Gonen Fusun Toruner 《Growth hormone & IGF research》2007,17(3):186-193
OBJECTIVE: Our aim was to determine whether serum Insulin-like growth factor-I (IGF-I) and Insulin-like growth factor binding protein-1 (IGFBP-1) levels were different between type 2 diabetic patients and non-diabetic control group. We also aimed to establish any relationship that might exist between the serum IGF-I and IGFBP-1 levels with the urinary albumin excretion (UAE), creatinine clearance and urinary N-acetyl-beta-D-glucosaminidase (NAG) excretion (as a marker of renal tubular dysfunction) and other parameters (such as age, duration of diabetes, treatment, etc.) in patients with type 2 diabetes mellitus (DM). DESIGN: Fifty-nine type 2 diabetic patients and thirty-one non-diabetic controls were included in this study. RESULTS: Mean serum IGF-I levels in diabetic patients were lower than the non-diabetic controls (158+/-12 vs. 287+/-26microg/l), (p<0.001). Serum IGFBP-1 levels were also higher in type 2 diabetic patients compared to the control group (67+/-5 vs. 35+/-4microg/l), (p<0.001). No relationship was obtained between IGF-I and IGFBP-1 levels with neither UAE nor urinary NAG excretion. A significant negative relationship was observed between creatinine clearance and serum IGFBP-1 level (r=-0.39, p=0.004). In multiple regression analysis IGF-I was independently and negatively associated with age and insulin treatment. On the other hand, IGFBP-1 was negatively related with creatinine clearance and positively related with the duration of diabetes. CONCLUSION: These results suggest that type 2 DM leads to a decrease in the IGF-I while elevating the IGFBP-1 levels. Further studies are needed to clarify a potential role of increased levels of IGFBP-1 in decreased creatinine clearance in type 2 DM. 相似文献
65.
Gulfer Okumus Esen Kiyan Orhan Arseven Levent Tabak Reyhan Diz-Kucukkaya Yesim Unlucerci Neslihan Abaci Nihan Erginel Unaltuna Halim Issever 《Clinical and applied thrombosis/hemostasis》2008,14(2):168-173
The aim of this study was to investigate the hereditary thrombophilic risk factors in patients with venous thromboembolism (VTE) and whether these risk factors play a different role in patients with isolated pulmonary embolism (PE) as compared with patients with deep vein thrombosis (DVT) and patients with PE + DVT. The protein C (PC), protein S, antithrombin activities, homocysteine levels, and factor V Leiden (FVL) G1691A and prothrombin G20210A mutations were evaluated in 191 patients with VTE and 191 controls. The prevalence of FVL and PC deficiency were higher in patients (P = .003 and P = .02, respectively). There was no significant difference for the other risk factors. The combination of thrombophilic risk factors was significantly higher in patients with DVT + PE as compared with patients with isolated PE or DVT (P = .04). In conclusion, the most important hereditary risk factors for VTE in this study were the FVL mutation and PC deficiency. 相似文献
66.
Altintas Nuray S. Orenay E. Reyhan M. Turk M. Asci S. Turel A. Yolasigmaz Altintas Nazmiye 《Helminthologia》2007,44(2):57-61
Summary Cystic echinococcosis (CE) due to Echinococcus granulosus is one of the most important helminthic diseases in Turkey where it constitutes a public health and economic problems. Its
mean annual incidence in humans is 4.4/100 000 and the prevalence of the tapeworm agent in domestic animals ranges from 11.2
to 50.7 %. Since 1980s, albendazole has been used for treatment of the disease, and this benzimidazole drug has been considered
to be of relatively low toxicity. However, prolonged albendazole therapy of CE became to be a common practice, and data on
possible genotoxic effects of the medication in humans are lacking. This study has concerned 17 women and 11 men, in total
28 patients with liver cystic hydatid complaints, who were administered albendazole (15 mg/kg) preoperatively (2 weeks) and
postoperatively (6 months). Genotoxic effects of albendazole were searched using Sister Chromatid Exchange (SCE), mitotic
index (MI) and chromosomal aberations (CAs) methods, comparing lymphocyte chromosomes of treated patients and a control group
of healthy individuals. The results indicated a significant increase of SCE frequencies and decrease of MI in the treated
group (p < 0.001). Regarding CAs, any difference between the groups was not determined. 相似文献
67.
Bayram NA Ersoy R Sen DO Inancli SS Durmaz T Keles T Bozkurt E Cakir B 《Endocrine》2010,37(2):280-285
We aimed to investigate the aortic function and to evaluate the relationship between aortic stiffness and systolic and diastolic functions of the left ventricle in patients with Cushing's disease (CD). Fourteen women and one man with newly diagnosed CD, and 17 control cases were enrolled in this study. All subjects underwent echocardiography and systolic and diastolic aortic measurements were noted from M-mode aortic root. Aortic elastic parameters, aortic strain, and distensibility were calculated. Left ventricle functions were measured using echocardiography including, two-dimensional, M-mode, conventional Doppler, and tissue Doppler imaging. Aortic strain (7.4 ± 1.9 vs. 12.3 ± 2.4%; P < 0.001), and aortic distensibility (3.2 ± 1.1 × 10?? vs. 5.6 ± 1.4 × 10?? cm2 dyn?1; P < 0.001) were significantly decreased in patient group compared with control group. Mitral E velocity and the ratio of E/A were significantly lower and deceleration time of E was significantly prolonged in patients with CD. We also observed that patients with CD had markedly lower early diastolic myocardial peak velocity (Em) and Em/Am ratio and higher Tei index than in control group. Aortic elastic parameters are deranged in patients with CD and there is a significant correlation between left ventricular parameters determined by tissue Doppler echocardiography and aortic elastic parameters in these patients. We think that patients with CD should also be evaluated with aortic stiffness known to be an early marker for atherosclerosis. 相似文献
68.
Necmettin Colak Yunus Nazli Irfan Tasoglu Reyhan Bayrak Mehmet Fatih Alpay Omer Nuri Aksoy Ismail Olgun Akkaya Omer Cakir 《The Canadian journal of cardiology》2013
Background
Mitomycin-C has been in clinical use primarily as a chemotherapeutic agent and is well known for antifibrotic properties. It has been widely used to prevent postoperative fibroblast proliferation and reduce scar adhesion in ophthalmologic and otolaryngologic operations. We investigated the efficacy of mitomycin-C in reducing postoperative pericardial adhesions in a rabbit model.Methods
New Zealand white rabbits were used and categorized into 2 groups, study (use of mitomycin-C) and control. Group 1 (n = 8) was treated with a sponge impregnated with mitomycin-C solution that was applied over the abraded epicardium. In group 2 (control group), the sponge was impregnated with 0.9% isotonic NaCl solution and was applied with the same protocol as the mitomycin-C–impregnated sponge in group 1 (n = 8). Rabbits were humanely killed at a mean of 2 weeks. The scores of adhesion were graded by macroscopic examination, and the pericardial tissues were analyzed microscopically in terms of inflammation and fibrosis.Results
In group 1, the adhesion scores were significantly lower than the control group's. No significant difference was found between the groups in terms of the severity of inflammation. There was a difference between groups in terms of the degree of fibrosis.Conclusions
The use of mitomycin-C to prevent postoperative pericardial adhesions reduced adhesion and fibrosis scores in an experimental rabbit model. However, efficacy in reducing inflammation was not demonstrated. 相似文献69.
Keven K Calayoglu R Sengul S Dincer I Kutlay S Erturk S Erbay B Nergizoglu G 《Clinical transplantation》2008,22(3):360-365
Abstract: Background: Arterial stiffness and left ventricular hypertrophy (LVH) are major independent risk factors for cardiovascular disease in healthy and renal population. In this study, we aimed to investigate comparative long‐term effects of renal transplantation (RTx) and of hemodialysis (HD) on both arterial stiffness and LVH. Methods: Twenty‐eight RTx patients, 23 HD patients, and 20 healthy subjects were included in this prospective study. In addition to demographical and laboratory parameters, arterial stiffness [pulse wave velocity (PWV)] and left ventricular mass index (LVMi) were assessed before and one‐yr after RTx, and at the baseline and one‐yr later in HD patients. Results: There were no differences in the parameters between HD and RTx patients at baseline. PWV was significantly higher than that of healthy controls. After one yr, PWV had significantly decreased in RTx patients, but was unchanged in HD patients. Changes in PWV were significant when both groups were compared (p < 0.0001). Although LVMi significantly decreased after RTx (p = 0.02), changes were not significant between the groups. Conclusions: Renal transplantation markedly improved arterial stiffness, while it remained elevated in HD patients at the one‐yr follow‐up. There was no difference between maintenance HD and RTx groups with respect to impact on LVMi in the one‐yr follow‐up. 相似文献
70.
Turgut F Bayrak O Catal F Bayrak R Atmaca AF Koc A Akbas A Akcay A Unal D 《International urology and nephrology》2008,40(2):453-460
Background Renal ischemia/reperfusion (I/R) injury is a major cause of acute renal failure. Silymarin is extracted from Silybum marianum and Cynara cardunculus seeds and fruits. The aim of this study is to investigate whether silymarin administration prevents the damage induced by
I/R in rat kidneys.
Materials and methods Thirty male Wistar rats were randomly divided into five experimental groups (n = 6, each) as follows; control group, sham-operated group, I/R group, silymarin group, and I/R + silymarin group. In the
I/R and I/R + silymarin groups, both renal arteries were occluded using nontraumatic microvascular clamps for 45 min. Then,
at the end of 24 h of reperfusion, the animals were killed. Kidney function tests, the serum and tissue antioxidant enzymes
and oxidant products were determined.
Results Animals that were subjected to I/R exhibited significant increase in serum urea, creatinine, and cystatin C levels compared
with the rats treated with silymarin prior to the I/R process (P < 0.001). The serum enzymatic activities of superoxide dismutase and glutathione peroxidase significantly decreased in the
I/R group; however, this reduction was significantly improved by the treatment with silymarin (P < 0.001 and P < 0.05, respectively). Renal I/R produced a significant increase in serum and tissue malondialdehyde, nitric oxide, and protein
carbonyl as compared with controls. Treatment with silymarin resulted in significant reduction in these markers (P < 0.001).
Conclusion Based on our findings, silymarin protects the kidneys against I/R injury. This finding may provide a basis for the development
of novel therapeutic strategies for protection against the damages caused by I/R. 相似文献