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281.
Uz E Bayrak O Uz E Kaya A Bayrak R Uz B Turgut FH Bavbek N Kanbay M Akcay A 《American journal of nephrology》2008,28(3):517-522
Nephrotoxicity is the main secondary effect of cyclosporine A (CsA) treatment. The antioxidant action of Nigella sativa oil (NSO) may explain the protective effect of these agents against various hepatotoxic and nephrotoxic models in vivo and in vitro. This study was designed to investigate the possible protective effects of NSO, in prevention of chronic CsA-induced nephrotoxicity in rats. Animals were randomly divided into four experimental groups: the control group received sunflower oil, the other groups were treated with CsA (25 mg/kg/day b.w. orally) or NSO (2 ml/kg orally) or CsA + NSO, respectively. Urine and serum creatinine levels, tissue superoxide dismutase, glutathione peroxidase and catalase enzyme activities, and nitric oxide and malondialdehyde levels were measured, and histological examination was performed. In our study, CsA caused a significant deterioration in the renal function, morphology and gave rise to severe oxidative stress in the kidney. NSO significantly improved the functional and histological parameters and attenuated the oxidative stress induced by CsA. In conclusion, our study demonstrated for the first time that NSO protects kidney tissue against oxygen free radicals, preventing renal dysfunction and morphological abnormalities associated with chronic CsA administration. 相似文献
282.
283.
Keskinoglu P Giray H Picakciefe M Bilgic N Ucku R 《Archives of gerontology and geriatrics》2006,43(1):93-100
The aim of this study is to determine the prevalence of and risk factors of dementia in the elderly with a low socio-economical status. The study is a cross-sectional and analytic study. Two hundred and four persons aged 65 years and above were selected by using the cluster sampling method. The presence of dementia was determined by Standardized Mini Mental State Examination (SMMSE). Twenty-three and 18 cut-off points were accepted as the existence of dementia in educated and uneducated older individuals, respectively. Chi-square test, Student's t-test, and logistic regression analysis were used for data analysis. The mean age of older subjects was 70.8+/-6.45 (S.D.); 71.5+/-5.9 in males and 70.3+/-6.8 in females (p=0.19). Ninety-one percent of older people had never attended school, 54.6% were living below the poverty level, and 97% of the residences were in squatter settlements. Dementia was determined in 46 older subjects (22.9%). Dementia was found significantly higher in females, in elderly subjects aged 80 years and above, in older subjects who were in a bad or very bad self-health status and in those who had a chronic disease, did not have any occupation, had a lower monthly income, and with a depressive score eight and above (p<0.05). In our study, the prevalence of dementia in older people was higher, in agreement with many reported studies. We assumed that this was due to the fact that the ratio of the uneducated, poor, and advanced aged subjects in this study was considerably higher. The different prevalence rates in studies demonstrate that the adoption of SMMSE for the study population, the validity-reliability analyses of tests and the standardization of diagnostic criteria are necessary. 相似文献
284.
Cihat Sanli Nursel Akalin Ulker Kocak Reyhan Erol Meryem Albayrak Didem Aliefendioglu Selda Hizel 《Pediatric cardiology》2010,31(7):991-996
Chest pain, a frequent complaint during childhood, rarely originates from a cardiac pathology. Although it usually is idiopathic,
it also could be associated with psychogenic, musculoskeletal, respiratory, and digestive disorders. This study aimed to investigate
a possible relation between bone mineral density and chest pain in children. Bone mineral density and bone metabolism parameters
were measured for 50 children with chest pain, and the findings were compared with those for 40 age- and sex-matched healthy
children. Most of the cases (64%) were in the idiopathic group, and musculoskeletal chest pain was the second most frequent
complaint (12%). Although bone mineral densities and osteocalcin levels did not differ significantly between the whole chest
pain group and the control group, both were found to be lower in the musculoskeletal chest pain group than in other groups
and the control group (p < 0.05). Musculoskeletal chest pain may be related to reduced bone mineral metabolism, and monitoring of risk factors is
of particular importance. 相似文献